NGM Biopharmaceuticals, Inc.
METHODS OF TREATING GASTROINTESTINAL MOTILITY-RELATED DISORDERS USING VARIANTS AND FUSIONS OF FGF19/FGF21 POLYPEPTIDES

Abstract:

Provided herein are methods of treating or preventing gastrointestinal motility-related disorders, treating or preventing constipation or stimulating bowel function, comprising using variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics).