| Utility: HTRA1-BINDING AGENTS AND METHODS OF USE THEREOF Filling date: 6 Sep 2025 Issue date: 11 Aug 2022 | 7 Feb 2022 | 11 Aug 2022 |
| Utility: METHODS AND USES FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES Filling date: 6 Sep 2025 Issue date: 4 Aug 2022 | 27 Dec 2021 | 4 Aug 2022 |
| Utility: Methods of treating fibroblast growth factor 19-mediated cancers and tumors Filling date: 6 Sep 2025 Issue date: 28 Jun 2022 | 25 Aug 2017 | 28 Jun 2022 |
| Utility: Compositions and methods of use for treating metabolic disorders Filling date: 6 Sep 2025 Issue date: 14 Jun 2022 | 7 Feb 2020 | 14 Jun 2022 |
| Utility: C3-BINDING AGENTS AND METHODS OF USE THEREOF Filling date: 6 Sep 2025 Issue date: 21 Apr 2022 | 19 Aug 2021 | 21 Apr 2022 |
| Utility: Methods of Using Compositions Comprising Variants and Fusions of FGF19 Polypeptides for Treatment of Metabolic Disorders and Diseases Filling date: 6 Sep 2025 Issue date: 24 Mar 2022 | 23 Jun 2021 | 24 Mar 2022 |
| Utility: BINDING PROTEINS AND METHODS OF USE THEREOF Filling date: 6 Sep 2025 Issue date: 10 Mar 2022 | 5 Mar 2021 | 10 Mar 2022 |
| Utility: PHARMACEUTICAL COMPOSITIONS COMPRISING PEPTIDE VARIANTS AND METHODS OF USE THEREOF Filling date: 6 Sep 2025 Issue date: 17 Feb 2022 | 22 Jun 2021 | 17 Feb 2022 |
| Utility: LAIR-1-BINDING AGENTS AND METHODS OF USE THEREOF Filling date: 6 Sep 2025 Issue date: 10 Feb 2022 | 21 Jun 2021 | 10 Feb 2022 |
| Utility: Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases Filling date: 6 Sep 2025 Issue date: 8 Feb 2022 | 11 Oct 2019 | 8 Feb 2022 |
| Utility: Compositions and Methods of Use for Treating Metabolic Disorders Filling date: 6 Sep 2025 Issue date: 16 Dec 2021 | 26 May 2021 | 16 Dec 2021 |
| Utility: ILT-BINDING AGENTS AND METHODS OF USE THEREOF Filling date: 6 Sep 2025 Issue date: 18 Nov 2021 | 29 Apr 2021 | 18 Nov 2021 |
| Utility: GLUCAGON RECEPTOR BINDING PROTEINS AND METHODS OF USE THEREOF Filling date: 6 Sep 2025 Issue date: 28 Oct 2021 | 19 Mar 2021 | 28 Oct 2021 |
| Utility: Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders Filling date: 6 Sep 2025 Issue date: 12 Oct 2021 | 5 Sep 2019 | 12 Oct 2021 |
| Utility: Anti-C3 antibodies Filling date: 6 Sep 2025 Issue date: 5 Oct 2021 | 1 Apr 2019 | 5 Oct 2021 |
| Utility: COMBINATION THERAPY WITH GLUCAGON RECEPTOR ANTAGONISTS Filling date: 6 Sep 2025 Issue date: 16 Sep 2021 | 17 Feb 2021 | 16 Sep 2021 |
| Utility: Methods of using compositions comprising variants of FGF19 polypeptides for reducing bile acid synthesis in a subject having cirrhosis Filling date: 6 Sep 2025 Issue date: 31 Aug 2021 | 21 Feb 2019 | 31 Aug 2021 |
| Utility: BISPECIFIC ANTIBODIES Filling date: 6 Sep 2025 Issue date: 19 Aug 2021 | 2 Jul 2019 | 19 Aug 2021 |
| Utility: ILT3-BINDING AGENTS AND METHODS OF USE THEREOF Filling date: 6 Sep 2025 Issue date: 22 Jul 2021 | 17 Dec 2020 | 22 Jul 2021 |
| Utility: Compositions comprising variants and fusions of FGF19 polypeptides Filling date: 6 Sep 2025 Issue date: 20 Jul 2021 | 11 Dec 2018 | 20 Jul 2021 |
| Utility: Compositions comprising fusion variants of FGF19 polypeptides Filling date: 6 Sep 2025 Issue date: 20 Jul 2021 | 25 Jun 2018 | 20 Jul 2021 |
| Utility: B7-H7-BINDING AGENTS AND METHODS OF USE THEREOF Filling date: 6 Sep 2025 Issue date: 1 Jul 2021 | 20 Aug 2019 | 1 Jul 2021 |
| Utility: Compositions and Methods for Treatment of Metabolic Disorders and Diseases Filling date: 6 Sep 2025 Issue date: 10 Jun 2021 | 10 Aug 2020 | 10 Jun 2021 |
| Utility: Antibodies which bind human glucagon receptor Filling date: 6 Sep 2025 Issue date: 4 May 2021 | 26 Jan 2018 | 4 May 2021 |
| Utility: BETA KLOTHO-BINDING PROTEINS Filling date: 6 Sep 2025 Issue date: 22 Apr 2021 | 28 Aug 2020 | 22 Apr 2021 |
| Utility: Binding proteins and methods of use thereof Filling date: 6 Sep 2025 Issue date: 13 Apr 2021 | 12 Sep 2018 | 13 Apr 2021 |
| Utility: LEAP2 BINDING AGENTS AND COMPOSITIONS THEREOF Filling date: 6 Sep 2025 Issue date: 8 Apr 2021 | 14 Aug 2020 | 8 Apr 2021 |
| Utility: ANGPTL8-BINDING AGENTS AND METHODS OF USE THEREOF Filling date: 6 Sep 2025 Issue date: 1 Apr 2021 | 18 Aug 2020 | 1 Apr 2021 |
| Utility: Method of treating type I diabetes by administering a combination of a glucagon receptor antagonist and an anti-CD3 antibody Filling date: 6 Sep 2025 Issue date: 30 Mar 2021 | 26 Jul 2019 | 30 Mar 2021 |
| Utility: BINDING PROTEINS AND METHODS OF USE THEREOF Filling date: 6 Sep 2025 Issue date: 4 Feb 2021 | 14 Jul 2020 | 4 Feb 2021 |
| Utility: ANGIOPOIETIN-LIKE PROTEIN 8 POLYPEPTIDE FRAGMENTS AND COMPOSITIONS THEREOF Filling date: 6 Sep 2025 Issue date: 21 Jan 2021 | 29 May 2020 | 21 Jan 2021 |
| Utility: Compositions and methods of use for treating metabolic disorders Filling date: 6 Sep 2025 Issue date: 22 Dec 2020 | 14 Dec 2018 | 22 Dec 2020 |
| Utility: METHODS FOR TREATMENT OF BILE ACID-RELATED DISORDERS Filling date: 6 Sep 2025 Issue date: 17 Dec 2020 | 30 Jun 2020 | 17 Dec 2020 |
| Utility: Combination Therapy for Modulating Bile Acid Homeostasis and Treatment of Bile Acid Disorders and Diseases Filling date: 6 Sep 2025 Issue date: 17 Dec 2020 | 16 Apr 2020 | 17 Dec 2020 |
| Utility: METHODS OF TREATING GASTROINTESTINAL MOTILITY-RELATED DISORDERS USING VARIANTS AND FUSIONS OF FGF19/FGF21 POLYPEPTIDES Filling date: 6 Sep 2025 Issue date: 22 Oct 2020 | 20 Apr 2018 | 22 Oct 2020 |
| Utility: Beta klotho-binding proteins Filling date: 6 Sep 2025 Issue date: 13 Oct 2020 | 29 Jul 2016 | 13 Oct 2020 |
| Utility: LEAP2 binding agents and compositions thereof Filling date: 6 Sep 2025 Issue date: 22 Sep 2020 | 23 May 2018 | 22 Sep 2020 |
| Utility: ANGPTL8-binding agents and methods of use thereof Filling date: 6 Sep 2025 Issue date: 15 Sep 2020 | 8 Nov 2018 | 15 Sep 2020 |
| Utility: Methods of using compositions comprising variants and fusions of FGF 19 polypeptides for treating diabetes Filling date: 6 Sep 2025 Issue date: 1 Sep 2020 | 10 Apr 2018 | 1 Sep 2020 |
| Utility: Beta klotho-binding proteins and methods of use thereof Filling date: 6 Sep 2025 Issue date: 18 Aug 2020 | 14 Aug 2018 | 18 Aug 2020 |
| Utility: Methods of using variants of FGF19 polypeptides for the treatment of pruritus Filling date: 6 Sep 2025 Issue date: 18 Aug 2020 | 8 Nov 2016 | 18 Aug 2020 |
| Utility: Angiopoietin-like protein 8 polypeptide fragments and compositions thereof Filling date: 6 Sep 2025 Issue date: 7 Jul 2020 | 6 Aug 2018 | 7 Jul 2020 |
| Utility: PHARMACEUTICAL COMPOSITIONS COMPRISING PEPTIDE VARIANTS AND METHODS OF USE THEREOF Filling date: 6 Sep 2025 Issue date: 25 Jun 2020 | 18 Dec 2019 | 25 Jun 2020 |
| Utility: METHODS AND USES FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES Filling date: 6 Sep 2025 Issue date: 25 Jun 2020 | 11 Oct 2019 | 25 Jun 2020 |
| Utility: Compositions and Methods of Use for Treating Metabolic Disorders Filling date: 6 Sep 2025 Issue date: 28 May 2020 | 7 Feb 2020 | 28 May 2020 |
| Utility: METHODS FOR TREATMENT OF BILE ACID-RELATED DISORDERS AND PREDICTION OF CLINICAL SENSITIVITY TO TREATMENT OF BILE ACID-RELATED DISORDERS Filling date: 6 Sep 2025 Issue date: 28 May 2020 | 5 Sep 2019 | 28 May 2020 |
| Utility: METHODS OF USING VARIANTS OF FGF19 POLYPEPTIDES FOR THE TREATMENT OF CANCER Filling date: 6 Sep 2025 Issue date: 28 May 2020 | 26 Jun 2019 | 28 May 2020 |
| Utility: Compositions and Methods of Use for Treating Metabolic Disorders Filling date: 6 Sep 2025 Issue date: 7 May 2020 | 15 Jan 2020 | 7 May 2020 |
| Utility: Compositions and methods of use for treating metabolic disorders Filling date: 6 Sep 2025 Issue date: 7 Apr 2020 | 20 Oct 2017 | 7 Apr 2020 |
| Utility: Compositions and Methods of Use For Treating Metabolic Disorders Filling date: 6 Sep 2025 Issue date: 19 Mar 2020 | 29 Apr 2019 | 19 Mar 2020 |
