Sale
SVENSTRUP NIELS officer: SVP, Chem. Mfg & Controls officer: SVP, Chem. Mfg & Contr..
Common Stock 10,000 $13.41 $134,100 Purchase
RA CAPITAL MANAGEMENT, L.P. director, 10 percent owner: director, 10 percent owner:
Common Stock 2,557,593 $10.64 $27,212,790 Purchase
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Common Stock 1,694 $4.17 $7,056 Option
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Common Stock 2,381 $2.71 $6,453 Sale
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Common Stock 2,381 $16.04 $38,189 Option
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Stock Option (Right to Buy) 2,381 $2.71 $6,453 Option
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Common Stock 8,419 $2.71 $22,815 Sale
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Common Stock 8,419 $16.23 $136,615 Option
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Stock Option (Right to Buy) 8,419 $2.71 $22,815 Option
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Common Stock 18,150 $2.71 $49,187 Sale
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Common Stock 18,150 $16.18 $293,667 Option
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Stock Option (Right to Buy) 18,150 $2.71 $49,187 Option
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Common Stock 500 $2.71 $1,355 Sale
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Common Stock 500 $16.06 $8,028 Option
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Stock Option (Right to Buy) 500 $2.71 $1,355 Option
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Common Stock 1,800 $2.71 $4,878 Sale
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Common Stock 1,800 $16.04 $28,863 Option
MCARTHUR JAMES G director, officer: President and CEO director, officer: President an..
Stock Option (Right to Buy) 1,800 $2.71 $4,878 Option
GOYAL JAYA officer: EVP, Res. & Preclin. Dev. officer: EVP, Res. & Preclin. D..
Stock Option (Right to Buy) 392 $10.88 $4,265 Sale
GOYAL JAYA officer: EVP, Res. & Preclin. Dev. officer: EVP, Res. & Preclin. D..
Common Stock 392 $20 $7,840 Option
GOYAL JAYA officer: EVP, Res. & Preclin. Dev. officer: EVP, Res. & Preclin. D..
Common Stock 392 $10.88 $4,265 Sale
GOYAL JAYA officer: EVP, Res. & Preclin. Dev. officer: EVP, Res. & Preclin. D..
Common Stock 644 $17 $10,948 Option
GOYAL JAYA officer: EVP, Res. & Preclin. Dev. officer: EVP, Res. & Preclin. D..
Common Stock 644 $10.88 $7,007 Option
GOYAL JAYA officer: EVP, Res. & Preclin. Dev. officer: EVP, Res. & Preclin. D..
Stock Option (Right to Buy) 644 $10.88 $7,007 Option
GOYAL JAYA officer: EVP, Res. & Preclin. Dev. officer: EVP, Res. & Preclin. D..
Stock Option (Right to Buy) 3,679 $10.88 $40,028 Sale
GOYAL JAYA officer: EVP, Res. & Preclin. Dev. officer: EVP, Res. & Preclin. D..
Common Stock 3,679 $17.18 $63,213 Option
GOYAL JAYA officer: EVP, Res. & Preclin. Dev. officer: EVP, Res. & Preclin. D..
Common Stock 3,679 $10.88 $40,028 Option
GOYAL JAYA officer: EVP, Res. & Preclin. Dev. officer: EVP, Res. & Preclin. D..
Stock Option (Right to Buy) 1,677 $10.88 $18,246 Sale
GOYAL JAYA officer: EVP, Res. & Preclin. Dev. officer: EVP, Res. & Preclin. D..
Common Stock 1,677 $17.04 $28,568 Option
GOYAL JAYA officer: EVP, Res. & Preclin. Dev. officer: EVP, Res. & Preclin. D..
Common Stock 1,677 $10.88 $18,246 Option
SVENSTRUP NIELS officer: SVP, Chem. Mfg & Controls officer: SVP, Chem. Mfg & Contr..
Stock Option (Right to Buy) 10,000 $2.71 $27,100 Option
SVENSTRUP NIELS officer: SVP, Chem. Mfg & Controls officer: SVP, Chem. Mfg & Contr..
Common Stock 10,000 $2.71 $27,100 Purchase
RA CAPITAL MANAGEMENT, L.P. director, 10 percent owner director, 10 percent owner
Common Stock 249,749 $12 $2,996,988 Purchase
RA CAPITAL MANAGEMENT, L.P. director, 10 percent owner director, 10 percent owner
Common Stock 2,979,451 $12 $35,753,412 Purchase
FLYNN JAMES E other: Possible Member of 10% Group other: Possible Member of 10% G..
Common Stock 208,333 $12 $2,499,996