Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 87,786 $2.23 $195,763 Option
MACK DAVID HENRY director, officer: President and CEO director, officer: President an..
Common Stock 198,407 $0.53 $105,156 Sale
JALOTA DEEPIKA officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 4,104 $6.62 $27,168 Sale
ALLAND LEILA officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 6,291 $6.62 $41,646 Option
MACK DAVID HENRY director, officer: President and CEO director, officer: President an..
Employee Stock Option (right to buy) 85,500 $0.53 $45,315 Option
MACK DAVID HENRY director, officer: President and CEO director, officer: President an..
Common Stock 85,500 $0.53 $45,315 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 26,253 $15.93 $418,210 Option
MACK DAVID HENRY director, officer: President and CEO director, officer: President an..
Employee Stock Option (right to buy) 33,000 $0.53 $17,490 Option
MACK DAVID HENRY director, officer: President and CEO director, officer: President an..
Common Stock 33,000 $0.53 $17,490 Option
KUNG WINSTON officer: COO, CFO officer: COO, CFO
Stock Option (right to buy) 4,000 $3.22 $12,880 Option
KUNG WINSTON officer: COO, CFO officer: COO, CFO
Common Stock 4,000 $3.22 $12,880 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 34,500 $21.17 $730,365 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 75,000 $22.39 $1,679,250 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 365,000 $21.52 $7,854,800 Option
MACK DAVID HENRY director, officer: President and CEO director, officer: President an..
Stock Option (right to buy) 20,000 $1.37 $27,400 Option
MACK DAVID HENRY director, officer: President and CEO director, officer: President an..
Common Stock 20,000 $1.37 $27,400 Option
FLOWERS KIRSTEN director director
Stock Option (right to buy) 32,677 $19.06 $622,824 Option
MACK DAVID HENRY director, officer: President and CEO director, officer: President an..
Stock Option (right to buy) 9,000 $0.53 $4,770 Option
MACK DAVID HENRY director, officer: President and CEO director, officer: President an..
Common Stock 9,000 $0.53 $4,770 Sale
SCHROEDER THILO director director
Common Stock 800 $30.15 $24,120 Sale
SCHROEDER THILO director director
Common Stock 100 $30.08 $3,008 Sale
SCHROEDER THILO director director
Common Stock 11,541 $30.1 $347,384 Sale
SCHROEDER THILO director director
Common Stock 2,978 $30.03 $89,429 Sale
SCHROEDER THILO director director
Common Stock 5,708 $30.04 $171,468 Sale
SCHROEDER THILO director director
Common Stock 1,753 $30.11 $52,783 Sale
LEVINE ARNOLD J director director
Common Stock 3,500 $30 $105,000 Sale
SCHROEDER THILO director director
Common Stock 100 $30 $3,000 Sale
SCHROEDER THILO director director
Common Stock 711 $30.03 $21,351 Sale
SCHROEDER THILO director director
Common Stock 13,272 $30.2 $400,814 Sale
SCHROEDER THILO director director
Common Stock 5,171 $31.03 $160,456 Sale
SCHROEDER THILO director director
Common Stock 38,056 $30.44 $1,158,425 Option
ALLAND LEILA officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 100 $3.9 $390 Sale
ALLAND LEILA officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 100 $30.25 $3,025 Option
ALLAND LEILA officer: Chief Medical Officer officer: Chief Medical Officer
Employee Stock Option (right to buy) 100 $3.9 $390 Sale
SCHROEDER THILO director director
Common Stock 14,329 $30.31 $434,312 Option
ALLAND LEILA officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,900 $3.9 $15,210 Sale
ALLAND LEILA officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,900 $30.25 $117,975 Option
ALLAND LEILA officer: Chief Medical Officer officer: Chief Medical Officer
Employee Stock Option (right to buy) 3,900 $3.9 $15,210 Sale
SCHROEDER THILO director, 10 percent owner director, 10 percent owner
Common Stock 5,400 $30.15 $162,810 Sale
SCHROEDER THILO director, 10 percent owner director, 10 percent owner
Common Stock 21,986 $30.38 $667,935 Sale
SCHROEDER THILO director, 10 percent owner director, 10 percent owner
Common Stock 19,520 $30.12 $587,942 Sale
SCHROEDER THILO director, 10 percent owner director, 10 percent owner
Common Stock 13,233 $30.05 $397,652 Sale
SCHROEDER THILO director, 10 percent owner director, 10 percent owner
Common Stock 23,397 $30.5 $713,609 Sale
SCHROEDER THILO director, 10 percent owner director, 10 percent owner
Common Stock 1,045 $31.06 $32,458 Sale
SCHROEDER THILO director, 10 percent owner director, 10 percent owner
Common Stock 15,063 $30.39 $457,765 Sale
SCHROEDER THILO director, 10 percent owner director, 10 percent owner
Common Stock 6,091 $31.13 $189,613 Sale
SCHROEDER THILO director, 10 percent owner director, 10 percent owner
Common Stock 13,526 $31.01 $419,441 Sale
SCHROEDER THILO director, 10 percent owner director, 10 percent owner
Common Stock 14,490 $31.08 $450,349 Sale
LEVINE ARNOLD J director director
Common Stock 3,500 $29.5 $103,250 Sale
SCHROEDER THILO director, 10 percent owner director, 10 percent owner
Common Stock 23,138 $30.66 $709,411