Sale
FEINBERG LARRY N other: * See Remarks other: * See Remarks
Common Stock 150,918 N/A N/A Sale
FEINBERG LARRY N other: * See Remarks other: * See Remarks
Common Stock, par value $0.001 per share ("Common Stock") 49,325 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 34,028 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 2,898 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 15,171 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 14,775 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 2,600 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 44,296 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 40,929 N/A N/A Purchase
MELINCOFF GWEN A director director
Common Stock 10,000 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 600 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 100 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 51,404 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 31,391 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 14,229 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 8,764 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 214,682 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 94,911 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 24,824 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 7,225 N/A N/A Purchase
SINCLAIR ANDREW director director
Common Stock 2,300,000 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 2,563,750 N/A N/A Purchase
ABINGWORTH LLP 10 percent owner 10 percent owner
Common Stock 2,300,000 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 2,563,750 N/A N/A Sale
VIVO VENTURES V, LLC 10 percent owner 10 percent owner
Common Stock 23,322 N/A N/A Purchase
FEINBERG LARRY N other: * See Remarks other: * See Remarks
Common Stock 7,500 N/A N/A Purchase
FEINBERG LARRY N other: * See Remarks other: * See Remarks
Common Stock, par value $0.001 per share ("Common Stock") 49,569 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 33,900 N/A N/A Sale
BIOASIA MANGEMENT LLC 10 percent owner 10 percent owner
Common Stock 9,856 N/A N/A Sale
BIOASIA MANGEMENT LLC 10 percent owner 10 percent owner
Common Stock 11,926 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 10,572 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 800 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 7,300 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 200 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 800 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 200 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 8,448 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 1,200 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 5,000 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 10,818 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 4,548 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 20,769 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 10,562 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 21,953 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 6,000 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 2,100 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 47,293 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 30,000 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 10,000 N/A N/A Purchase
SCHULER JACK W 10 percent owner 10 percent owner
Common Stock 5,000 N/A N/A