Sutro Biopharma, Inc.
PD-1/TIM-3 BI-SPECIFIC ANTIBODIES, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME

Abstract:

Provided herein are antibodies that selectively bind to Tim-3 and its isoforms and homologs, and compositions comprising the antibodies. Also provided herein are antibodies that selectively bind to PD-1 and its isoforms and homologs, and compositions comprising the antibodies. In addition, provided herein are bi-specific antibodies and antigen binding constructs that selectively bind to Tim-3 and/or PD-1, their isoforms and homologs, and compositions comprising the antibodies and antigen binding constructs. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.