| Utility: 1-(4-(AMINOMETHYL)BENZYL)-2-BUTYL-2H-PYRAZOLO[3,4-C]QUINOLIN-4-AMINE DERIVATIVES AND RELATED COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR) 7/8 AGONISTS, AS WELL AS ANTIBODY DRUG CONJUGATES THEREOF FOR USE IN CANCER THERAPY AND DIAGNOSIS Filling date: 26 Sep 2025 Issue date: 18 Aug 2022 | 17 Jun 2020 | 18 Aug 2022 |
| Utility: Formulations for drying bacterial cell extracts Filling date: 26 Sep 2025 Issue date: 9 Aug 2022 | 6 Apr 2020 | 9 Aug 2022 |
| Utility: E. coli strains having an oxidative cytoplasm Filling date: 26 Sep 2025 Issue date: 9 Aug 2022 | 7 Nov 2019 | 9 Aug 2022 |
| Utility: 5H-PYRROLO[3,2-d]PYRIMIDINE-2,4-DIAMINO COMPOUNDS AND ANTIBODY CONJUGATES THEREOF Filling date: 26 Sep 2025 Issue date: 4 Aug 2022 | 10 Jun 2020 | 4 Aug 2022 |
| Utility: ANTIBODIES WITH ENGINEERED CH2 DOMAINS, COMPOSITIONS THEREOF AND METHODS OF USING THE SAME Filling date: 26 Sep 2025 Issue date: 30 Jun 2022 | 28 Jul 2021 | 30 Jun 2022 |
| Utility: Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use Filling date: 26 Sep 2025 Issue date: 31 May 2022 | 15 Aug 2017 | 31 May 2022 |
| Utility: ANTI-EpCAM ANTIBODIES, COMPOSITIONS COMPRISING ANTI-EpCAM ANTIBODIES AND METHODS OF MAKING AND USING ANTI-EpCAM ANTIBODIES Filling date: 26 Sep 2025 Issue date: 7 Apr 2022 | 5 Aug 2021 | 7 Apr 2022 |
| Utility: METHOD FOR LARGE SCALE PRODUCTION OF ANTIBODIES USING A CELL-FREE PROTEIN SYNTHESIS SYSTEM Filling date: 26 Sep 2025 Issue date: 24 Mar 2022 | 13 Sep 2021 | 24 Mar 2022 |
| Utility: Proteolytic inactivation of select proteins in bacterial extracts for improved expression Filling date: 26 Sep 2025 Issue date: 1 Mar 2022 | 6 Sep 2019 | 1 Mar 2022 |
| Utility: COMBINATION THERAPIES WITH ANTI-FOLATE RECEPTOR ANTIBODY CONJUGATES Filling date: 26 Sep 2025 Issue date: 17 Feb 2022 | 16 Sep 2019 | 17 Feb 2022 |
| Utility: ANTI-TIM-3 ANTIBODIES, COMPOSITIONS COMPRISING ANTI-TIM-3 ANTIBODIES AND METHODS OF MAKING AND USING ANTI-TIM-3 ANTIBODIES Filling date: 26 Sep 2025 Issue date: 30 Dec 2021 | 6 May 2021 | 30 Dec 2021 |
| Utility: E. COLI STRAINS HAVING AN OXIDATIVE CYTOPLASM Filling date: 26 Sep 2025 Issue date: 11 Nov 2021 | 7 Nov 2019 | 11 Nov 2021 |
| Utility: Methods of Producing Full-Length Antibodies Using E. coli Filling date: 26 Sep 2025 Issue date: 4 Nov 2021 | 29 Apr 2021 | 4 Nov 2021 |
| Utility: ANTI-CD74 ANTIBODIES, COMPOSITIONS COMPRISING ANTI-CD74 ANTIBODIES AND METHODS OF USING ANTI-CD74 ANTIBODIES Filling date: 26 Sep 2025 Issue date: 16 Sep 2021 | 9 Mar 2021 | 16 Sep 2021 |
| Utility: HEMIASTERLIN DERIVATIVES FOR CONJUGATION AND THERAPY Filling date: 26 Sep 2025 Issue date: 26 Aug 2021 | 2 Nov 2020 | 26 Aug 2021 |
| Utility: Antibodies with engineered CH2 domains, compositions thereof and methods of using the same Filling date: 26 Sep 2025 Issue date: 24 Aug 2021 | 14 Jun 2017 | 24 Aug 2021 |
| Utility: Anti-EpCAM antibodies, compositions comprising anti-EpCAM antibodies and methods of making and using anti-EpCAM antibodies Filling date: 26 Sep 2025 Issue date: 24 Aug 2021 | 28 Jul 2016 | 24 Aug 2021 |
| Utility: HEMIASTERLIN DERIVATIVES FOR CONJUGATION AND THERAPY Filling date: 26 Sep 2025 Issue date: 1 Jul 2021 | 2 Nov 2020 | 1 Jul 2021 |
| Utility: Anti-Tim-3 antibodies, compositions comprising anti-Tim-3 antibodies and methods of making and using anti-Tim-3 antibodies Filling date: 26 Sep 2025 Issue date: 25 May 2021 | 17 Aug 2016 | 25 May 2021 |
| Utility: ANTI-BCMA RECEPTOR ANTIBODIES, COMPOSITIONS COMPRISING ANTI BCMA RECEPTOR ANTIBODIES AND METHODS OF MAKING AND USING ANTI-BCMA ANTIBODIES Filling date: 26 Sep 2025 Issue date: 6 May 2021 | 25 Mar 2019 | 6 May 2021 |
| Utility: ANTI-PD-1 ANTIBODIES, COMPOSITIONS COMPRISING ANTI-PD-1 ANTIBODIES AND METHODS OF USING ANTI-PD-1 ANTIBODIES Filling date: 26 Sep 2025 Issue date: 15 Apr 2021 | 12 Oct 2020 | 15 Apr 2021 |
| Utility: Anti-CD74 antibodies, compositions comprising anti-CD74 antibodies and methods of using anti-CD74 antibodies Filling date: 26 Sep 2025 Issue date: 13 Apr 2021 | 20 Jul 2015 | 13 Apr 2021 |
| Utility: EXPRESSION OF BIOLOGICALLY ACTIVE PROTEINS IN A BACTERIAL CELL-FREE SYNTHESIS SYSTEM USING BACTERIAL CELLS TRANSFORMED TO EXHIBIT ELEVATED LEVELS OF CHAPERONE EXPRESSION Filling date: 26 Sep 2025 Issue date: 25 Feb 2021 | 12 Aug 2020 | 25 Feb 2021 |
| Utility: IMMUNOMODULATOR ANTIBODY DRUG CONJUGATES AND USES THEREOF Filling date: 26 Sep 2025 Issue date: 31 Dec 2020 | 10 Jun 2020 | 31 Dec 2020 |
| Utility: Hemiasterlin derivatives for conjugation and therapy Filling date: 26 Sep 2025 Issue date: 24 Nov 2020 | 29 Jan 2016 | 24 Nov 2020 |
| Utility: MODIFIED AMINO ACIDS Filling date: 26 Sep 2025 Issue date: 19 Nov 2020 | 4 Aug 2020 | 19 Nov 2020 |
| Utility: ANTI-FOLATE RECEPTOR ALPHA ANTIBODY CONJUGATES AND THEIR USES Filling date: 26 Sep 2025 Issue date: 12 Nov 2020 | 17 Sep 2018 | 12 Nov 2020 |
| Utility: Anti-PD-1 antibodies, compositions comprising anti-PD-1 antibodies and methods of using anti-PD-1 antibodies Filling date: 26 Sep 2025 Issue date: 3 Nov 2020 | 10 Nov 2015 | 3 Nov 2020 |
| Utility: USE OF LAMBDA-GAM PROTEIN IN RIBOSOMAL DISPLAY TECHNOLOGY Filling date: 26 Sep 2025 Issue date: 22 Oct 2020 | 2 Jul 2020 | 22 Oct 2020 |
| Utility: FORMULATIONS FOR DRYING BACTERIAL CELL EXTRACTS Filling date: 26 Sep 2025 Issue date: 24 Sep 2020 | 6 Apr 2020 | 24 Sep 2020 |
| Utility: ANTIBODIES COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE Filling date: 26 Sep 2025 Issue date: 24 Sep 2020 | 11 Mar 2020 | 24 Sep 2020 |
| Utility: Expression of biologically active proteins in a bacterial cell-free synthesis system using bacterial cells transformed to exhibit elevated levels of chaperone expression Filling date: 26 Sep 2025 Issue date: 15 Sep 2020 | 3 Dec 2018 | 15 Sep 2020 |
| Utility: MODIFIED FC PROTEINS COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, CONJUGATES OF THE SAME, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE Filling date: 26 Sep 2025 Issue date: 10 Sep 2020 | 26 Nov 2019 | 10 Sep 2020 |
| Utility: Modified amino acids Filling date: 26 Sep 2025 Issue date: 4 Aug 2020 | 29 Oct 2018 | 4 Aug 2020 |
| Utility: Use of lambda-gam protein in ribosomal display technology Filling date: 26 Sep 2025 Issue date: 4 Aug 2020 | 10 Jan 2018 | 4 Aug 2020 |
| Utility: METHODS OF USING ANTI-CD74 ANTIBODIES AND ANTIBODY CONJUGATES IN TREATMENT OF T-CELL LYMPHOMA Filling date: 26 Sep 2025 Issue date: 2 Jul 2020 | 25 Jul 2018 | 2 Jul 2020 |
| Utility: PD-1/TIM-3 BI-SPECIFIC ANTIBODIES, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME Filling date: 26 Sep 2025 Issue date: 18 Jun 2020 | 22 Feb 2018 | 18 Jun 2020 |
| Utility: Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use Filling date: 26 Sep 2025 Issue date: 2 Jun 2020 | 23 Jun 2017 | 2 Jun 2020 |
| Utility: ANTI-FOLATE RECEPTOR ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI-FOLATE RECEPTOR ANTIBODY CONJUGATES, AND METHODS OF MAKING AND USING ANTI-FOLATE RECEPTOR ANTIBODY CONJUGATES Filling date: 26 Sep 2025 Issue date: 14 May 2020 | 16 Sep 2019 | 14 May 2020 |
| Utility: Formulations for drying bacterial cell extracts Filling date: 26 Sep 2025 Issue date: 12 May 2020 | 8 Jan 2016 | 12 May 2020 |
| Utility: Anti-folate receptor antibody conjugates, compositions comprising anti-folate receptor antibody conjugates, and methods of making and using anti-folate receptor antibody conjugates Filling date: 26 Sep 2025 Issue date: 24 Mar 2020 | 17 Sep 2018 | 24 Mar 2020 |
| Utility: PD-1/LAG3 BI-SPECIFIC ANTIBODIES, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME Filling date: 26 Sep 2025 Issue date: 12 Mar 2020 | 23 May 2018 | 12 Mar 2020 |
| Utility: PROTEOLYTIC INACTIVATION OF SELECT PROTEINS IN BACTERIAL EXTRACTS FOR IMPROVED EXPRESSION Filling date: 26 Sep 2025 Issue date: 27 Feb 2020 | 6 Sep 2019 | 27 Feb 2020 |
| Utility: MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE Filling date: 26 Sep 2025 Issue date: 9 Jan 2020 | 18 Sep 2019 | 9 Jan 2020 |
| Utility: Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use Filling date: 26 Sep 2025 Issue date: 10 Dec 2019 | 23 Jun 2017 | 10 Dec 2019 |
| Utility: Codon optimization for titer and fidelity improvement Filling date: 26 Sep 2025 Issue date: 26 Nov 2019 | 18 Dec 2015 | 26 Nov 2019 |
| Utility: HIGH GROWTH CAPACITY AUXOTROPHIC ESCHERICHIA COLI AND METHODS OF USE Filling date: 26 Sep 2025 Issue date: 7 Nov 2019 | 26 Apr 2019 | 7 Nov 2019 |
| Utility: ANTI-LAG3 ANTIBODIES, COMPOSITIONS COMPRISING ANTI-LAG3 ANTIBODIES AND METHODS OF MAKING AND USING ANTI-LAG3 ANTIBODIES Filling date: 26 Sep 2025 Issue date: 31 Oct 2019 | 18 Nov 2016 | 31 Oct 2019 |
| Utility: Proteolytic inactivation of select proteins in bacterial extracts for improved expression Filling date: 26 Sep 2025 Issue date: 22 Oct 2019 | 10 Apr 2017 | 22 Oct 2019 |
| Utility: Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use Filling date: 26 Sep 2025 Issue date: 15 Oct 2019 | 6 Dec 2017 | 15 Oct 2019 |
