Sale
GREENSTEIN LEONARD M. officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,000 $16.03 $80,150 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 9,000 $16.01 $144,090 Purchase
LIN ELIZABETH YEU director director
Common Stock 6,360 $16.29 $103,604 Purchase
LIN ELIZABETH YEU director director
Common Stock 12,040 $16.03 $193,001 Option
MOTTIWALA AZIZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Employee Stock Option (right to buy) 772 $0.45 $347 Option
MOTTIWALA AZIZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Employee Stock Option (right to buy) 4,416 $10.99 $48,532 Option
MOTTIWALA AZIZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 772 $0.45 $347 Option
MOTTIWALA AZIZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 4,416 $10.99 $48,532 Sale
GREENSTEIN LEONARD M. officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,000 $16.3 $81,500 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 736 $17.44 $12,836 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 7,264 $16.5 $119,856 Option
ACKERMANN MICHAEL director director
Restricted Stock Units 4,257 N/A N/A Option
ACKERMANN MICHAEL director director
Common Stock 4,257 N/A N/A Sale
VIVO CAPITAL IX, LLC 10 percent owner 10 percent owner
Common Stock 5,374 $12.25 $65,832 Purchase
ACKERMANN MICHAEL director director
Common Stock 100,000 $13.5 $1,350,000 Sale
VIVO CAPITAL IX, LLC 10 percent owner 10 percent owner
Common Stock 19,738 $12.67 $250,080 Sale
VIVO CAPITAL IX, LLC 10 percent owner 10 percent owner
Common Stock 451,418 $13.25 $5,981,289 Sale
VIVO CAPITAL IX, LLC 10 percent owner 10 percent owner
Common Stock 41,800 $15.19 $634,942 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 5,833 $25.31 $147,604 Sale
ACKERMANN MICHAEL director director
Common Stock 5,833 $25.26 $147,353 Sale
MOTTIWALA AZIZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 1,889 $28.11 $53,100 Sale
MOTTIWALA AZIZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 11 $28.11 $309 Sale
MOTTIWALA AZIZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 100 $28.03 $2,803 Sale
MOTTIWALA AZIZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 6,000 $26.91 $161,472 Sale
ACKERMANN MICHAEL director director
Common Stock 5,833 $27.97 $163,149 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 5,833 $27.99 $163,237 Sale
ACKERMANN MICHAEL director director
Common Stock 5,633 $26.01 $146,486 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 5,531 $25.97 $143,612 Sale
ACKERMANN MICHAEL director director
Common Stock 200 $25.03 $5,006 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 302 $25.02 $7,555 Option
MOTTIWALA AZIZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Employee Stock Option (right to buy) 6,943 $5.72 $39,714 Sale
MOTTIWALA AZIZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 2,593 $22.15 $57,435 Option
MOTTIWALA AZIZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 6,943 $5.72 $39,714 Sale
ACKERMANN MICHAEL director, 10 percent owner director, 10 percent owner
Common Stock 5,833 $25.24 $147,237 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 5,833 $25.82 $150,585 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 1,917 $25.07 $48,061 Sale
ACKERMANN MICHAEL director, 10 percent owner director, 10 percent owner
Common Stock 621 $25.15 $15,619 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 103 $25 $2,575 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 827 $25.07 $20,729 Sale
ACKERMANN MICHAEL director, 10 percent owner director, 10 percent owner
Common Stock 700 $25 $17,500 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 1,616 $25 $40,400 Sale
ACKERMANN MICHAEL director, 10 percent owner director, 10 percent owner
Common Stock 3,129 $25 $78,225 Sale
AZAMIAN BOBAK R. director, officer: President and CEO director, officer: President an..
Common Stock 1,370 $25 $34,250 Sale
ACKERMANN MICHAEL director, 10 percent owner director, 10 percent owner
Common Stock 1,383 $25.01 $34,585 Sale
ACKERMANN MICHAEL director, 10 percent owner director, 10 percent owner
Common Stock 1,383 $25.01 $34,585 Sale
VIVO CAPITAL IX, LLC 10 percent owner 10 percent owner
Common Stock 7,704 $29.6 $228,038 Sale
VIVO CAPITAL IX, LLC 10 percent owner 10 percent owner
Common Stock 10,000 $29.9 $299,000 Sale
VIVO CAPITAL IX, LLC 10 percent owner 10 percent owner
Common Stock 37,980 $29.8 $1,131,804 Sale
VIVO CAPITAL IX, LLC 10 percent owner 10 percent owner
Common Stock 110,000 N/A N/A Sale
VIVO CAPITAL IX, LLC 10 percent owner 10 percent owner
Common Stock 91,620 N/A N/A