Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 36,600 $4.54 $166,164 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 13,700 $4.68 $64,116 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 378,000 $4.74 $1,791,720 Purchase
FIRESTONE GREGORY A. officer: Chief Business Officer officer: Chief Business Officer
Common Stock 2,600 $5.65 $14,687 Purchase
CUCA ROBERTO officer: COO and CFO officer: COO and CFO
Common Stock 10,000 $4.49 $44,940 Purchase
KOBLISH ANTONY director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 11,000 $4.54 $49,973 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 27,700 $9.41 $260,657 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 28,300 $9.43 $266,869 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 136,000 $9.3 $1,264,800 Option
BURGESS VINCENT J director director
Common Stock 4,860 $4.44 $21,578 Option
BURGESS VINCENT J director director
Stock Option (Right to Buy) 4,860 $4.44 $21,578 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 1,262 $7.81 $9,859 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 19,000 $7.81 $148,428 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 1,000 $8 $8,000 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 15,000 $8 $120,000 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 304 $7.99 $2,430 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 6,500 $7.99 $51,961 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 1,000 $8.09 $8,088 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 17,000 $8.09 $137,496 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 372 $8.08 $3,007 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 2,000 $8.08 $16,166 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 658 $8.1 $5,330 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 3,500 $8.1 $28,350 Purchase
EW HEALTHCARE PARTNERS FUND 2, L.P. other other
Common Stock, par value $0.001 per share 500,000 $8 $4,000,000 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 15,000 $8 $120,000 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 300,000 $8 $2,400,000 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 479 $8.52 $4,082 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 11,500 $8.52 $98,003 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 479 $7.96 $3,813 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 4,500 $7.96 $35,820 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 200 $8.02 $1,604 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 5,000 $8.02 $40,105 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 833 $8.08 $6,728 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 9,500 $8.03 $76,285 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 600 $8.08 $4,846 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 4,500 $8.08 $36,347 Purchase
EW HEALTHCARE PARTNERS FUND 2, L.P. other other
Common Stock, par value $0.001 per share 5,000 $8.03 $40,150 Purchase
EW HEALTHCARE PARTNERS FUND 2, L.P. other other
Common Stock, par value $0.001 per share 5,000 $8.02 $40,100 Purchase
EW HEALTHCARE PARTNERS FUND 2, L.P. other other
Common Stock, par value $0.001 per share 5,000 $8.02 $40,100 Purchase
EW HEALTHCARE PARTNERS FUND 2, L.P. other other
Common Stock, par value $0.001 per share 5,000 $7.96 $39,800 Purchase
EW HEALTHCARE PARTNERS FUND 2, L.P. other other
Common Stock, par value $0.001 per share 5,000 $8.07 $40,350 Purchase
EW HEALTHCARE PARTNERS FUND 2, L.P. other other
Common Stock, par value $0.001 per share 5,000 $7.86 $39,300 Purchase
EW HEALTHCARE PARTNERS FUND 2, L.P. other other
Common Stock, par value $0.001 per share 5,000 $7.52 $37,600 Purchase
EW HEALTHCARE PARTNERS FUND 2, L.P. other other
Common Stock, par value $0.001 per share 5,000 $7.27 $36,350 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 200 $7 $1,400 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 567 $7 $3,969 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 2,998 $7 $20,986 Purchase
OPALEYE MANAGEMENT INC. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 2 $6.99 $14 Purchase
EW HEALTHCARE PARTNERS FUND 2, L.P. other other
Common Stock, par value $0.001 per share 5,000 $7.1 $35,500 Purchase
EW HEALTHCARE PARTNERS FUND 2, L.P. other other
Common Stock, par value $0.001 per share 5,000 $7.09 $35,450