Purchase
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Common Stock 1,000 N/A N/A Purchase
SPADORO JOANNE officer: Chief Operations Officer officer: Chief Operations Officer
Common Stock 5,000 N/A N/A Option
LAPIDUS STANLEY director director
Common Stock 20,000 N/A N/A Purchase
ELSBREE DAVID B director director
Common Stock 10,000 N/A N/A Purchase
DEPTULA-HICKS DARLENE M officer: SVP & Chief Financial Off.. officer: SVP & Chief Financial ..
Common Stock 4,000 N/A N/A Option
LAPIDUS STANLEY director director
Stock Option (Right to Buy) 20,000 N/A N/A Option
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Common Stock 3,000 N/A N/A Option
LOWERY THOMAS J. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 4,000 N/A N/A Option
LOWERY THOMAS J. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 4,000 N/A N/A Option
LIEBMAN SEYMOUR director director
Restricted Stock Units 18,000 N/A N/A Option
CUMMING JOHN W director director
Restricted Stock Units 18,000 N/A N/A Option
CIMA MICHAEL J. director director
Restricted Stock Units 18,000 N/A N/A Option
ELSBREE DAVID B director director
Restricted Stock Units 18,000 N/A N/A Option
LAPIDUS STANLEY director director
Restricted Stock Units 18,000 N/A N/A Purchase
CIMA MICHAEL J. director director
Common Stock 1,400 N/A N/A Purchase
ELSBREE DAVID B director director
Common Stock 10,000 N/A N/A Sale
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Common Stock 3,589 N/A N/A Option
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Common Stock 3,589 N/A N/A Option
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Stock Option (Right to Buy) 3,589 N/A N/A Option
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Common Stock 7,588 N/A N/A Option
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Stock Option (Right to Buy) 4,647 N/A N/A Sale
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Common Stock 4,647 N/A N/A Option
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Common Stock 7,588 N/A N/A Option
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Common Stock 13,770 N/A N/A Option
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Stock Option (Right to Buy) 13,770 N/A N/A Sale
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Common Stock 13,770 N/A N/A Option
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Stock Option (Right to Buy) 2,700 N/A N/A Sale
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Common Stock 2,700 N/A N/A Option
DHANDA RAHUL officer: SVP of Corporate Development officer: SVP of Corporate Devel..
Common Stock 2,700 N/A N/A Purchase
GOLDMAN SACHS GROUP INC 10 percent owner 10 percent owner
Common Stock 700,000 N/A N/A Purchase
AISLING CAPITAL III LP 10 percent owner 10 percent owner
Common Stock 307,692 N/A N/A Purchase
MBD ADVISORS, L.L.C. 10 percent owner 10 percent owner
Common Stock 700,000 N/A N/A Purchase
ELSBREE DAVID B director director
Common Stock 10,000 N/A N/A Purchase
CARELLA THOMAS J. director director
Common Stock 700,000 N/A N/A Option
LOWERY THOMAS J. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 N/A N/A Option
LOWERY THOMAS J. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 2,000 N/A N/A Purchase
CIMA MICHAEL J. director director
Common Stock 1,000 N/A N/A Purchase
ELSBREE DAVID B director director
Common Stock 75 N/A N/A Sale
POLARIS VENTURE PARTNERS V, L.P. 10 percent owner 10 percent owner
Common Stock 10,744 N/A N/A Sale
POLARIS VENTURE PARTNERS V, L.P. 10 percent owner 10 percent owner
Common Stock 10,744 N/A N/A Sale
POLARIS VENTURE PARTNERS V, L.P. 10 percent owner 10 percent owner
Common Stock 400 N/A N/A Sale
POLARIS VENTURE PARTNERS V, L.P. 10 percent owner 10 percent owner
Common Stock 14,999 N/A N/A Sale
POLARIS VENTURE PARTNERS V, L.P. 10 percent owner 10 percent owner
Common Stock 14,999 N/A N/A Sale
POLARIS VENTURE PARTNERS V, L.P. 10 percent owner 10 percent owner
Common Stock 14,999 N/A N/A Sale
POLARIS VENTURE PARTNERS V, L.P. 10 percent owner 10 percent owner
Common Stock 14,999 N/A N/A Sale
POLARIS VENTURE PARTNERS V, L.P. 10 percent owner 10 percent owner
Common Stock 14,999 N/A N/A Sale
POLARIS VENTURE PARTNERS V, L.P. 10 percent owner 10 percent owner
Common Stock 14,999 N/A N/A Sale
POLARIS VENTURE PARTNERS V, L.P. 10 percent owner 10 percent owner
Common Stock 14,999 N/A N/A Sale
POLARIS VENTURE PARTNERS V, L.P. 10 percent owner 10 percent owner
Common Stock 14,999 N/A N/A Sale
POLARIS VENTURE PARTNERS V, L.P. 10 percent owner 10 percent owner
Common Stock 14,999 N/A N/A