Sale
MEISNER LARA officer: General Counsel and Secretary officer: General Counsel and Se..
Common Stock 300 $28.08 $8,424 Option
MEISNER LARA officer: General Counsel and Secretary officer: General Counsel and Se..
Common Stock 300 $23.03 $6,909 Option
MEISNER LARA officer: General Counsel and Secretary officer: General Counsel and Se..
Stock Option (Right to Buy) 15,656 $23.03 $360,558 Sale
MEISNER LARA officer: General Counsel and Secretary officer: General Counsel and Se..
Common Stock 15,656 $28.12 $440,247 Option
MEISNER LARA officer: General Counsel and Secretary officer: General Counsel and Se..
Common Stock 15,656 $23.03 $360,558 Option
MEISNER LARA officer: General Counsel and Secretary officer: General Counsel and Se..
Stock Option (Right to Buy) 600 $23.03 $13,818 Sale
MEISNER LARA officer: General Counsel and Secretary officer: General Counsel and Se..
Common Stock 600 $28.05 $16,830 Option
MEISNER LARA officer: General Counsel and Secretary officer: General Counsel and Se..
Common Stock 600 $23.03 $13,818 Option
MEISNER LARA officer: General Counsel and Secretary officer: General Counsel and Se..
Stock Option (Right to Buy) 8,125 $14 $113,750 Sale
MEISNER LARA officer: General Counsel and Secretary officer: General Counsel and Se..
Common Stock 8,125 $22.05 $179,156 Option
MEISNER LARA officer: General Counsel and Secretary officer: General Counsel and Se..
Common Stock 8,125 $14 $113,750 Purchase
FAIRMOUNT FUNDS MANAGEMENT LLC other: See Remarks other: See Remarks
Common Stock 425,531 $23.5 $9,999,979 Sale
VIOLIN JONATHAN director, officer: Chief Executive Officer director, officer: Chief Execu..
Common Stock 30,000 $12.2 $366,000 Sale
VIOLIN JONATHAN director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 30,000 $13.04 $391,200 Sale
VIOLIN JONATHAN director, officer: Chief Executive Officer director, officer: Chief Execu..
Common Stock 3,600 $18.93 $68,148 Sale
VIOLIN JONATHAN director, officer: Chief Executive Officer director, officer: Chief Execu..
Common Stock 26,400 $18.92 $499,488 Sale
VIOLIN JONATHAN director, officer: Chief Executive Officer director, officer: Chief Execu..
Common Stock 11,106 $17.36 $192,800 Sale
VIOLIN JONATHAN director, officer: Chief Executive Officer director, officer: Chief Execu..
Common Stock 18,894 $17.82 $336,691 Sale
VIOLIN JONATHAN director, officer: Chief Executive Officer director, officer: Chief Execu..
Common Stock 909 $19.16 $17,416 Sale
VIOLIN JONATHAN director, officer: Chief Executive Officer director, officer: Chief Execu..
Common Stock 12,340 $18.47 $227,920 Sale
VIOLIN JONATHAN director, officer: Chief Executive Officer director, officer: Chief Execu..
Common Stock 16,751 $19.55 $327,482 Purchase
FRAZIER LIFE SCIENCES PUBLIC FUND, L.P. 10 percent owner 10 percent owner
Common Stock 200,000 $11 $2,200,000 Purchase
FAIRMOUNT FUNDS MANAGEMENT LLC director, 10 percent owner director, 10 percent owner
Common Stock 909,000 $11 $9,999,000 Purchase
LOGOS GLOBAL MASTER FUND LP
Common Stock 126,667 N/A N/A Purchase
LOGOS GLOBAL MASTER FUND LP
Common Stock 350,000 N/A N/A Purchase
LOGOS GLOBAL MASTER FUND LP
Common Stock 350,000 N/A N/A Purchase
FAIRMOUNT FUNDS MANAGEMENT LLC
Series A Non-Voting Convertible Preferred Stock 34,337 N/A N/A Option
LEVERONE JASON A.
Common Stock 11,249 $0.57 $6,412 Option
LEVERONE JASON A.
Stock Option (right to buy) 11,249 $0.57 $6,412 Option
LEVERONE JASON A.
Common Stock 3,093 N/A N/A Option
LEVERONE JASON A.
Stock Option (right to buy) 3,093 N/A N/A Purchase
HUGHES THOMAS E.
Common Stock 10,000 $4.77 $47,700 Option
LEVERONE JASON A.
Common Stock 29,530 $0.57 $16,832 Option
LEVERONE JASON A.
Stock Option (right to buy) 29,530 $0.57 $16,832 Purchase
BOOTH BRUCE
Common Stock 545,454 $5.5 $2,999,997 Purchase
LEVY ADAM SCOTT
Common Stock 9,090 $5.5 $49,995 Option
MARSHALL WILLIAM STUART
Common Stock 115,818 $0.57 $66,016 Option
MARSHALL WILLIAM STUART
Stock Option (right to buy) 115,818 $0.57 $66,016 Sale
HUGHES THOMAS E.
Common Stock 12,000 $8 $96,000