Sale
FRANCIS CHRIS officer: See Remarks officer: See Remarks
Ordinary Shares 24,496 $2.48 $60,750 Sale
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Ordinary Shares 20,250 $45 $911,250 Option
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Share Option (right to buy) 20,250 $45 $911,250 Option
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Ordinary Shares 20,250 $45 $911,250 Option
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Ordinary Shares 3,145 $45 $141,525 Sale
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Ordinary Shares 3,145 $45 $141,525 Option
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Share Option (right to buy) 3,145 $45 $141,525 Option
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Share Option (right to buy) 8,316 $2.48 $20,624 Option
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Ordinary Shares 8,316 $2.48 $20,624 Sale
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Ordinary Shares 8,316 $2.48 $20,624 Sale
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Ordinary Shares 18,289 $2.48 $45,357 Option
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Share Option (right to buy) 18,289 $2.48 $45,357 Option
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Ordinary Shares 18,289 $2.48 $45,357 Option
FRANCIS CHRIS officer: See Remarks officer: See Remarks
Ordinary Shares 11,504 $55.95 $643,649 Sale
FRANCIS CHRIS officer: See Remarks officer: See Remarks
Ordinary Shares 11,504 $55.95 $643,649 Option
FRANCIS CHRIS officer: See Remarks officer: See Remarks
Share Option (right to buy) 11,504 N/A N/A Option
FRANCIS CHRIS officer: See Remarks officer: See Remarks
Ordinary Shares 9,412 $2.48 $23,342 Option
FRANCIS CHRIS officer: See Remarks officer: See Remarks
Share Option (right to buy) 9,412 $2.48 $23,342 Sale
FRANCIS CHRIS officer: See Remarks officer: See Remarks
Ordinary Shares 723 $51.8 $37,451 Sale
PANZARA MICHAEL A. officer: Chief Medical Officer officer: Chief Medical Officer
Ordinary Shares 511 $52.1 $26,623 Sale
REGNANTE KEITH officer: Chief Financial Officer officer: Chief Financial Officer
Ordinary Shares 316 $51.85 $16,385 Sale
BOLNO PAUL director, officer: President and CEO director, officer: President an..
Ordinary Shares 2,714 $51.32 $139,269 Sale
VARGEESE CHANDRA officer: Senior VP, Drug Discovery officer: Senior VP, Drug Discov..
Ordinary Shares 2,000 $2.48 $4,960 Option
VARGEESE CHANDRA officer: Senior VP, Drug Discovery officer: Senior VP, Drug Discov..
Share Option (right to buy) 2,000 $2.48 $4,960 Option
VARGEESE CHANDRA officer: Senior VP, Drug Discovery officer: Senior VP, Drug Discov..
Ordinary Shares 2,000 $2.48 $4,960 Sale
PANZARA MICHAEL A. officer: Chief Medical Officer officer: Chief Medical Officer
Ordinary Shares 18,750 $21.69 $406,688 Option
PANZARA MICHAEL A. officer: Chief Medical Officer officer: Chief Medical Officer
Ordinary Shares 18,750 $21.69 $406,688 Option
PANZARA MICHAEL A. officer: Chief Medical Officer officer: Chief Medical Officer
Share Option (right to buy) 18,750 $21.69 $406,688 Option
VARGEESE CHANDRA officer: Senior VP, Drug Discovery officer: Senior VP, Drug Discov..
Share Option (right to buy) 2,000 $2.48 $4,960 Option
VARGEESE CHANDRA officer: Senior VP, Drug Discovery officer: Senior VP, Drug Discov..
Ordinary Shares 2,000 $2.48 $4,960 Sale
VARGEESE CHANDRA officer: Senior VP, Drug Discovery officer: Senior VP, Drug Discov..
Ordinary Shares 2,000 $2.48 $4,960 Option
VARGEESE CHANDRA officer: Senior VP, Drug Discovery officer: Senior VP, Drug Discov..
Ordinary Shares 1,500 $2.48 $3,720 Sale
VARGEESE CHANDRA officer: Senior VP, Drug Discovery officer: Senior VP, Drug Discov..
Ordinary Shares 1,500 $2.48 $3,720 Option
VARGEESE CHANDRA officer: Senior VP, Drug Discovery officer: Senior VP, Drug Discov..
Share Option (right to buy) 1,500 $2.48 $3,720 Purchase
RA CAPITAL MANAGEMENT, LLC director, 10 percent owner director, 10 percent owner
Ordinary Shares 23,398 $24 $561,552 Purchase
RA CAPITAL MANAGEMENT, LLC director, 10 percent owner director, 10 percent owner
Ordinary Shares 400,000 $23.3 $9,320,000 Sale
TANAKA MASAHARU director, 10 percent owner director, 10 percent owner
Ordinary Shares 6,362 $24.19 $153,897 Sale
TANAKA MASAHARU director, 10 percent owner director, 10 percent owner
Ordinary Shares 14,385 $24.22 $348,405 Sale
PANZARA MICHAEL A. officer: Chief Medical Officer officer: Chief Medical Officer
Ordinary Shares 7,414 $16.67 $123,621 Sale
TANAKA MASAHARU director, 10 percent owner director, 10 percent owner
Ordinary Shares 433,825 $24.91 $10,806,581 Option
GUERCIOLINI ROBERTO officer: See Remarks officer: See Remarks
Share Option (Right to Buy) 24,000 $2.47 $59,280 Option
GUERCIOLINI ROBERTO officer: See Remarks officer: See Remarks
Ordinary Shares 24,000 $2.47 $59,280 Option
GUERCIOLINI ROBERTO officer: See Remarks officer: See Remarks
Ordinary Shares 5,000 $2.47 $12,350 Option
GUERCIOLINI ROBERTO officer: See Remarks officer: See Remarks
Share Option (Right to Buy) 5,000 $2.47 $12,350 Option
GUERCIOLINI ROBERTO officer: See Remarks officer: See Remarks
Ordinary Shares 5,000 $2.47 $12,350 Option
GUERCIOLINI ROBERTO officer: See Remarks officer: See Remarks
Share Option (Right to Buy) 5,000 $2.47 $12,350 Sale
VERDINE GREGORY L. director director
Ordinary Shares 52,000 $16.7 $868,400 Purchase
TAKANASHI KEN director, 10 percent owner director, 10 percent owner
Ordinary Shares 125,000 $16 $2,000,000 Purchase
TANAKA MASAHARU director, 10 percent owner director, 10 percent owner
Ordinary Shares 76,250 $16 $1,220,000 Purchase
RA CAPITAL MANAGEMENT, LLC director, 10 percent owner director, 10 percent owner
Ordinary Shares 1,875,000 $16 $30,000,000