| Utility: Isolation and purification of anti-IL-13 antibodies using protein a affinity chromatography Filling date: 12 Sep 2025 Issue date: 19 Jul 2022 | 6 Apr 2018 | 19 Jul 2022 |
| Utility: Methods of treatment of diseases in which IL-13 activity is detrimental using anti-IL-13 antibodies Filling date: 12 Sep 2025 Issue date: 19 Jul 2022 | 27 Apr 2017 | 19 Jul 2022 |
| Utility: Melt-extruded solid dispersions containing an apoptosis-inducing agent Filling date: 12 Sep 2025 Issue date: 28 Jun 2022 | 24 Jul 2014 | 28 Jun 2022 |
| Utility: Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2- -trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof Filling date: 12 Sep 2025 Issue date: 21 Jun 2022 | 16 Nov 2021 | 21 Jun 2022 |
| Utility: Medication packaging and dispensing system Filling date: 12 Sep 2025 Issue date: 14 Jun 2022 | 17 Jul 2020 | 14 Jun 2022 |
| Utility: Methods of treating heavy menstrual bleeding Filling date: 12 Sep 2025 Issue date: 31 May 2022 | 29 Jan 2020 | 31 May 2022 |
| Utility: Interleukin-13 binding proteins Filling date: 12 Sep 2025 Issue date: 31 May 2022 | 27 Aug 2018 | 31 May 2022 |
| Utility: Organic reactions carried out in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose Filling date: 12 Sep 2025 Issue date: 26 Apr 2022 | 1 Oct 2020 | 26 Apr 2022 |
| Utility: Dosing regimens for use in treating myelofibrosis and MPN-related disorders with navitoclax Filling date: 12 Sep 2025 Issue date: 29 Mar 2022 | 4 Nov 2020 | 29 Mar 2022 |
| Utility: Enzyme compositions with reduced viral and microbial contamination Filling date: 12 Sep 2025 Issue date: 22 Mar 2022 | 27 Sep 2017 | 22 Mar 2022 |
| Utility: Solid pharmaceutical compositions for treating HCV Filling date: 12 Sep 2025 Issue date: 15 Feb 2022 | 16 Oct 2019 | 15 Feb 2022 |
| Utility: Crystal forms Filling date: 12 Sep 2025 Issue date: 8 Feb 2022 | 4 Dec 2017 | 8 Feb 2022 |
| Utility: Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2- -trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof Filling date: 12 Sep 2025 Issue date: 14 Dec 2021 | 14 Apr 2021 | 14 Dec 2021 |
| Utility: Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2- -trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof Filling date: 12 Sep 2025 Issue date: 30 Nov 2021 | 14 Apr 2021 | 30 Nov 2021 |
| Utility: Prodrug modulators of the integrated stress pathway Filling date: 12 Sep 2025 Issue date: 19 Oct 2021 | 9 Apr 2021 | 19 Oct 2021 |
| Utility: 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof Filling date: 12 Sep 2025 Issue date: 14 Sep 2021 | 9 Nov 2018 | 14 Sep 2021 |
| Utility: Combination therapy of a type II anti-CD20 antibody with a selective Bcl-2 inhibitor Filling date: 12 Sep 2025 Issue date: 7 Sep 2021 | 26 Feb 2021 | 7 Sep 2021 |
| Utility: Methods of treating Parkinson's disease Filling date: 12 Sep 2025 Issue date: 17 Aug 2021 | 4 May 2020 | 17 Aug 2021 |
| Utility: Medicine container, method of assembling the container, and method of dispensing the medicine from the container Filling date: 12 Sep 2025 Issue date: 6 Jul 2021 | 22 Mar 2018 | 6 Jul 2021 |
| Utility: Methods of treating heavy menstrual bleeding Filling date: 12 Sep 2025 Issue date: 29 Jun 2021 | 15 Mar 2019 | 29 Jun 2021 |
| Utility: Anti-huLRRC15 antibody drug conjugates and methods for their use Filling date: 12 Sep 2025 Issue date: 29 Jun 2021 | 13 Dec 2018 | 29 Jun 2021 |
| Utility: Combination therapy of a type II anti-CD20 antibody with a selective BCL-2 inhibitor Filling date: 12 Sep 2025 Issue date: 4 May 2021 | 23 Mar 2020 | 4 May 2021 |
| Utility: Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2- -trifluoroethyl)pyrrolidine-1-carb oxamide and solid state forms thereof Filling date: 12 Sep 2025 Issue date: 4 May 2021 | 19 Dec 2019 | 4 May 2021 |
| Utility: Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2- -trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof Filling date: 12 Sep 2025 Issue date: 20 Apr 2021 | 3 Aug 2020 | 20 Apr 2021 |
| Utility: Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[l,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2- -trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof Filling date: 12 Sep 2025 Issue date: 20 Apr 2021 | 18 Jun 2020 | 20 Apr 2021 |
| Utility: Protein tyrosine phosphatase inhibitors and methods of use thereof Filling date: 12 Sep 2025 Issue date: 23 Mar 2021 | 18 Sep 2020 | 23 Mar 2021 |
| Utility: Methods and compositions for treating asthma using anti-IL-13 antibodies Filling date: 12 Sep 2025 Issue date: 16 Feb 2021 | 27 Jun 2017 | 16 Feb 2021 |
| Utility: Modulators of the integrated stress pathway Filling date: 12 Sep 2025 Issue date: 9 Feb 2021 | 5 May 2017 | 9 Feb 2021 |
| Utility: Methods of treating heavy menstrual bleeding Filling date: 12 Sep 2025 Issue date: 5 Jan 2021 | 14 Mar 2014 | 5 Jan 2021 |
| Utility: High purity oritavancin and method of producing same Filling date: 12 Sep 2025 Issue date: 15 Dec 2020 | 11 Jun 2019 | 15 Dec 2020 |
| Utility: Modulators of the integrated stress pathway Filling date: 12 Sep 2025 Issue date: 15 Dec 2020 | 5 May 2017 | 15 Dec 2020 |
| Utility: Automatic injection device Filling date: 12 Sep 2025 Issue date: 8 Dec 2020 | 25 May 2018 | 8 Dec 2020 |
| Utility: Protein tyrosine phosphatase inhibitors and methods of use thereof Filling date: 12 Sep 2025 Issue date: 1 Dec 2020 | 4 Jun 2020 | 1 Dec 2020 |
| Utility: Organic reactions carried out in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose Filling date: 12 Sep 2025 Issue date: 17 Nov 2020 | 14 Jan 2020 | 17 Nov 2020 |
| Utility: Modulators of the integrated stress pathway Filling date: 12 Sep 2025 Issue date: 17 Nov 2020 | 5 May 2017 | 17 Nov 2020 |
| Utility: Fused heterocyclic derivatives as S1P modulators Filling date: 12 Sep 2025 Issue date: 10 Nov 2020 | 30 Jan 2019 | 10 Nov 2020 |
| Utility: Composition and method for the diagnosis and treatment of iron-related disorders Filling date: 12 Sep 2025 Issue date: 3 Nov 2020 | 2 Nov 2018 | 3 Nov 2020 |
| Utility: Spiro-cyclic amine derivatives as S1P modulators Filling date: 12 Sep 2025 Issue date: 20 Oct 2020 | 13 Nov 2018 | 20 Oct 2020 |
| Utility: Systems and methods for tubing delivery Filling date: 12 Sep 2025 Issue date: 20 Oct 2020 | 10 Jul 2015 | 20 Oct 2020 |
| Utility: Glucocorticoid receptor agonist and immunoconjugates thereof Filling date: 12 Sep 2025 Issue date: 15 Sep 2020 | 29 Nov 2018 | 15 Sep 2020 |
| Utility: Cylindrical pill dispenser and related methods of use Filling date: 12 Sep 2025 Issue date: 18 Aug 2020 | 11 Dec 2015 | 18 Aug 2020 |
| Utility: Systems and methods for tubing delivery Filling date: 12 Sep 2025 Issue date: 18 Aug 2020 | 10 Jul 2014 | 18 Aug 2020 |
| Utility: Medication packaging and dispensing system Filling date: 12 Sep 2025 Issue date: 11 Aug 2020 | 14 Oct 2016 | 11 Aug 2020 |
| Utility: Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2- -trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof Filling date: 12 Sep 2025 Issue date: 4 Aug 2020 | 11 Feb 2020 | 4 Aug 2020 |
| Utility: Carbidopa prodrug Filling date: 12 Sep 2025 Issue date: 4 Aug 2020 | 5 Dec 2018 | 4 Aug 2020 |
| Utility: Salts and crystalline forms of an apoptosis-inducing agent Filling date: 12 Sep 2025 Issue date: 4 Aug 2020 | 8 Nov 2017 | 4 Aug 2020 |
| Utility: Enzymatic processes for the preparation of (.+-.)-2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid and (.+-.)-2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid Filling date: 12 Sep 2025 Issue date: 23 Jun 2020 | 1 Feb 2018 | 23 Jun 2020 |
| Utility: Methods of administering elagolix Filling date: 12 Sep 2025 Issue date: 16 Jun 2020 | 20 Dec 2019 | 16 Jun 2020 |
| Utility: Macrocyclic MCL-1 inhibitors and methods of use Filling date: 12 Sep 2025 Issue date: 9 Jun 2020 | 15 Aug 2018 | 9 Jun 2020 |
| Utility: Medicine container, method of assembling the container, and method of dispensing the medicine from the container Filling date: 12 Sep 2025 Issue date: 9 Jun 2020 | 5 Jan 2016 | 9 Jun 2020 |
