| Utility: METHODS OF TREATMENT OF DISEASES IN WHICH IL-13 ACTIVITY IS DETRIMENTAL USING ANTI-IL-13 ANTIBODIES Filling date: 12 Sep 2025 Issue date: 8 Sep 2022 | 10 May 2022 | 8 Sep 2022 |
| Utility: PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2- -TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF Filling date: 12 Sep 2025 Issue date: 8 Sep 2022 | 9 Feb 2022 | 8 Sep 2022 |
| Utility: METHODS OF TREATING CROHN'S DISEASE AND ULCERATIVE COLITIS Filling date: 12 Sep 2025 Issue date: 1 Sep 2022 | 28 Apr 2022 | 1 Sep 2022 |
| Utility: MEDICATION PACKAGING AND DISPENSING SYSTEM Filling date: 12 Sep 2025 Issue date: 25 Aug 2022 | 10 May 2022 | 25 Aug 2022 |
| Utility: PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2- -TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF Filling date: 12 Sep 2025 Issue date: 25 Aug 2022 | 2 May 2022 | 25 Aug 2022 |
| Utility: COMBINATION THERAPY OF A TYPE II ANTI-CD20 ANTIBODY WITH A SELECTIVE BCL-2 INHIBITOR Filling date: 12 Sep 2025 Issue date: 25 Aug 2022 | 30 Mar 2022 | 25 Aug 2022 |
| Utility: ANTI-CD40 ANTIBODY DRUG CONJUGATES Filling date: 12 Sep 2025 Issue date: 25 Aug 2022 | 29 Nov 2018 | 25 Aug 2022 |
| Utility: MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE Filling date: 12 Sep 2025 Issue date: 18 Aug 2022 | 22 Apr 2022 | 18 Aug 2022 |
| Utility: METHODS OF TREATING CROHN'S DISEASE AND ULCERATIVE COLITIS Filling date: 12 Sep 2025 Issue date: 18 Aug 2022 | 6 Jan 2022 | 18 Aug 2022 |
| Utility: PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2- -TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF Filling date: 12 Sep 2025 Issue date: 11 Aug 2022 | 11 Apr 2022 | 11 Aug 2022 |
| Utility: PRODRUG MODULATORS OF THE INTEGRATED STRESS PATHWAY Filling date: 12 Sep 2025 Issue date: 11 Aug 2022 | 2 Sep 2021 | 11 Aug 2022 |
| Utility: METHODS OF TREATING CROHN'S DISEASE AND ULCERATIVE COLITIS Filling date: 12 Sep 2025 Issue date: 28 Jul 2022 | 1 Apr 2022 | 28 Jul 2022 |
| Utility: Anti-EGFR Antibody-Drug Conjugates Filling date: 12 Sep 2025 Issue date: 21 Jul 2022 | 20 Jan 2022 | 21 Jul 2022 |
| Utility: Isolation and purification of anti-IL-13 antibodies using protein a affinity chromatography Filling date: 12 Sep 2025 Issue date: 19 Jul 2022 | 6 Apr 2018 | 19 Jul 2022 |
| Utility: Methods of treatment of diseases in which IL-13 activity is detrimental using anti-IL-13 antibodies Filling date: 12 Sep 2025 Issue date: 19 Jul 2022 | 27 Apr 2017 | 19 Jul 2022 |
| Utility: ENZYME COMPOSITIONS WITH REDUCED VIRAL AND MICROBIAL CONTAMINATION Filling date: 12 Sep 2025 Issue date: 7 Jul 2022 | 21 Mar 2022 | 7 Jul 2022 |
| Utility: BICYCLIC PYRAZOLE BRUTON'S TYROSINE KINASE INHIBITORS Filling date: 12 Sep 2025 Issue date: 7 Jul 2022 | 16 Dec 2021 | 7 Jul 2022 |
| Utility: COMBINATION THERAPY OF A TYPE II ANTI-CD20 ANTIBODY WITH A SELECTIVE BCL-2 INHIBITOR Filling date: 12 Sep 2025 Issue date: 7 Jul 2022 | 5 Aug 2021 | 7 Jul 2022 |
| Utility: Melt-extruded solid dispersions containing an apoptosis-inducing agent Filling date: 12 Sep 2025 Issue date: 28 Jun 2022 | 24 Jul 2014 | 28 Jun 2022 |
| Utility: Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2- -trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof Filling date: 12 Sep 2025 Issue date: 21 Jun 2022 | 16 Nov 2021 | 21 Jun 2022 |
| Utility: Medication packaging and dispensing system Filling date: 12 Sep 2025 Issue date: 14 Jun 2022 | 17 Jul 2020 | 14 Jun 2022 |
| Design: Sleeve container Filling date: 12 Sep 2025 Issue date: 14 Jun 2022 | 7 Nov 2019 | 14 Jun 2022 |
| Utility: Methods of treating heavy menstrual bleeding Filling date: 12 Sep 2025 Issue date: 31 May 2022 | 29 Jan 2020 | 31 May 2022 |
| Utility: Interleukin-13 binding proteins Filling date: 12 Sep 2025 Issue date: 31 May 2022 | 27 Aug 2018 | 31 May 2022 |
| Utility: METHODS OF TREATING PARKINSON'S DISEASE Filling date: 12 Sep 2025 Issue date: 19 May 2022 | 16 Jul 2021 | 19 May 2022 |
| Design: Sleeve container Filling date: 12 Sep 2025 Issue date: 17 May 2022 | 7 Nov 2019 | 17 May 2022 |
| Utility: SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT Filling date: 12 Sep 2025 Issue date: 28 Apr 2022 | 7 Jun 2021 | 28 Apr 2022 |
| Utility: Organic reactions carried out in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose Filling date: 12 Sep 2025 Issue date: 26 Apr 2022 | 1 Oct 2020 | 26 Apr 2022 |
| Utility: MODULATORS OF THE INTEGRATED STRESS PATHWAY Filling date: 12 Sep 2025 Issue date: 7 Apr 2022 | 1 Dec 2020 | 7 Apr 2022 |
| Utility: Dosing regimens for use in treating myelofibrosis and MPN-related disorders with navitoclax Filling date: 12 Sep 2025 Issue date: 29 Mar 2022 | 4 Nov 2020 | 29 Mar 2022 |
| Utility: Enzyme compositions with reduced viral and microbial contamination Filling date: 12 Sep 2025 Issue date: 22 Mar 2022 | 27 Sep 2017 | 22 Mar 2022 |
| Utility: METHODS OF TREATING HEAVY MENSTRUAL BLEEDING Filling date: 12 Sep 2025 Issue date: 17 Mar 2022 | 18 Nov 2021 | 17 Mar 2022 |
| Utility: PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2- -TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF Filling date: 12 Sep 2025 Issue date: 10 Mar 2022 | 16 Nov 2021 | 10 Mar 2022 |
| Utility: Solid pharmaceutical compositions for treating HCV Filling date: 12 Sep 2025 Issue date: 15 Feb 2022 | 16 Oct 2019 | 15 Feb 2022 |
| Utility: Crystal forms Filling date: 12 Sep 2025 Issue date: 8 Feb 2022 | 4 Dec 2017 | 8 Feb 2022 |
| Utility: METHODS FOR TREATING SPINAL CORD INJURY AND PAIN Filling date: 12 Sep 2025 Issue date: 27 Jan 2022 | 9 Mar 2021 | 27 Jan 2022 |
| Utility: WEARABLE AUTOMATIC INJECTION DEVICE FOR CONTROLLED ADMINISTRATION OF THERAPEUTIC AGENTS Filling date: 12 Sep 2025 Issue date: 27 Jan 2022 | 1 Mar 2021 | 27 Jan 2022 |
| Utility: ANTI-ALPHA-4-BETA-7 ANTIBODIES Filling date: 12 Sep 2025 Issue date: 20 Jan 2022 | 16 Jul 2021 | 20 Jan 2022 |
| Utility: Bromodomain Inhibitors Filling date: 12 Sep 2025 Issue date: 20 Jan 2022 | 24 Feb 2021 | 20 Jan 2022 |
| Utility: MONOCLONAL ANTIBODIES AGAINST AMYLOID BETA PROTEIN AND USES THEREOF Filling date: 12 Sep 2025 Issue date: 20 Jan 2022 | 22 Feb 2021 | 20 Jan 2022 |
| Utility: APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES Filling date: 12 Sep 2025 Issue date: 30 Dec 2021 | 4 Feb 2021 | 30 Dec 2021 |
| Utility: MODULATORS OF THE INTEGRATED STRESS PATHWAY Filling date: 12 Sep 2025 Issue date: 23 Dec 2021 | 2 Nov 2018 | 23 Dec 2021 |
| Utility: Methods of Treating Acute HCV Filling date: 12 Sep 2025 Issue date: 16 Dec 2021 | 20 Nov 2019 | 16 Dec 2021 |
| Utility: Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2- -trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof Filling date: 12 Sep 2025 Issue date: 14 Dec 2021 | 14 Apr 2021 | 14 Dec 2021 |
| Utility: SYRINGE WITH TWO-STAGE SEALING PRESSURE Filling date: 12 Sep 2025 Issue date: 9 Dec 2021 | 15 Jan 2021 | 9 Dec 2021 |
| Utility: METHODS OF TREATMENT OF DISEASES IN WHICH IL-13 ACTIVITY IS DETRIMENTAL USING ANTI-IL-13 ANTIBODIES Filling date: 12 Sep 2025 Issue date: 9 Dec 2021 | 27 Apr 2017 | 9 Dec 2021 |
| Utility: Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2- -trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof Filling date: 12 Sep 2025 Issue date: 30 Nov 2021 | 14 Apr 2021 | 30 Nov 2021 |
| Utility: PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2- -TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF Filling date: 12 Sep 2025 Issue date: 25 Nov 2021 | 24 Feb 2021 | 25 Nov 2021 |
| Utility: METHODS OF TREATING CROHN'S DISEASE AND ULCERATIVE COLITIS Filling date: 12 Sep 2025 Issue date: 25 Nov 2021 | 9 Dec 2020 | 25 Nov 2021 |
| Utility: MODULATORS OF THE INTEGRATED STRESS PATHWAY Filling date: 12 Sep 2025 Issue date: 25 Nov 2021 | 30 Apr 2020 | 25 Nov 2021 |
