Purchase
ISRAEL BIOTECH FUND I, L.P. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 658,858 N/A N/A Purchase
ISRAEL BIOTECH FUND I, L.P. 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 658,858 N/A N/A Purchase
ISRAEL BIOTECH FUND I, L.P. 10 percent owner 10 percent owner
Convertible Promissory Note 0 N/A N/A Purchase
ISRAEL BIOTECH FUND I, L.P. 10 percent owner 10 percent owner
Convertible Promissory Note 0 N/A N/A Sale
APPEL RONI director director
Common Stock 2,401 $0.55 $1,321 Sale
APPEL RONI director director
Common Stock 200 $0.58 $116 Sale
APPEL RONI director director
Common Stock 399 $0.67 $267 Purchase
APPEL RONI director director
Common Stock 3,000 $3.8 $11,391 Sale
PETIT ROBERT officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 3,963 $0.58 $2,299 Sale
PETIT ROBERT officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 8,491 $0.56 $4,755 Purchase
APPEL RONI director director
Common Stock Warrants 28,333 $1.5 $42,500 Purchase
APPEL RONI director director
Common Stock 33,333 $1.2 $40,000 Sale
PETIT ROBERT officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,193 $1.62 $3,553 Sale
LOMBARDO ANTHONY A officer: Interim CEO officer: Interim CEO
Common Stock 32 $2.93 $94 Sale
BONSTEIN SARA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,224 $3.18 $16,612 Sale
PETIT ROBERT officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 3,723 $3.3 $12,286 Sale
BONSTEIN SARA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 3,862 $3.3 $12,745 Sale
LOMBARDO ANTHONY A officer: Interim CEO officer: Interim CEO
Common Stock 24 $3.19 $77 Sale
PETIT ROBERT officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 12,625 $3.19 $40,274 Sale
BONSTEIN SARA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 12,734 $3.19 $40,621 Sale
ADAGE CAPITAL PARTNERS GP, L.L.C. 10 percent owner 10 percent owner
Common Stock, par value $0.001 ("Common Stock") 600,000 $4.3 $2,580,000 Sale
ADAGE CAPITAL PARTNERS GP, L.L.C. 10 percent owner 10 percent owner
Common Stock 300,000 $4 $1,200,000 Sale
ADAGE CAPITAL PARTNERS GP, L.L.C. 10 percent owner 10 percent owner
Common Stock 405,323 $4.38 $1,775,315 Sale
ADAGE CAPITAL PARTNERS GP, L.L.C. 10 percent owner 10 percent owner
Common Stock, par value $0.001 ("Common Stock") 534,000 $4.68 $2,499,120 Sale
PETIT ROBERT officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,454 $8.24 $20,221 Sale
BONSTEIN SARA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,520 $7.37 $40,682 Sale
MCKEARN THOMAS J director director
Common Stock 12,316 $8.08 $99,513 Sale
O'CONNOR DANIEL director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 8,240 $8.32 $68,557 Sale
PETIT ROBERT officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,797 $8.32 $23,271 Sale
MAYES, GREGORY T. director director
Common Stock 19,162 $8.23 $157,703 Sale
BERMAN RICHARD J director director
Common Stock 15,761 $15.67 $246,975 Sale
SIDRANSKY DAVID director director
Common stock 11,404 $14.85 $169,349 Sale
BERMAN RICHARD J director director
Common Stock 18,000 $15.21 $273,780 Sale
SIDRANSKY DAVID director director
Common stock 11,404 $14.85 $169,349 Sale
MCKEARN THOMAS J director director
Common Stock 4,100 $7.45 $30,545 Sale
PETIT ROBERT officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,785 $7.51 $20,915 Sale
O'CONNOR DANIEL director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 8,237 $7.51 $61,860 Sale
PETIT ROBERT officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 3,325 $9.13 $30,357 Sale
MCKEARN THOMAS J director director
Common Stock 14,000 $8.25 $115,500 Sale
BONSTEIN SARA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 15,037 $5.58 $83,906 Sale
O'CONNOR DANIEL director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 8,818 $6.88 $60,668 Sale
PETIT ROBERT officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 3,099 $6.88 $21,321 Sale
BERMAN RICHARD J director director
Common Stock 14,332 $12.39 $177,573 Sale
O'CONNOR DANIEL director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 8,350 $12.26 $102,371 Sale
PETIT ROBERT officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,867 $12.26 $35,149 Sale
MAYES, GREGORY T. director director
Common Stock 19,231 $11.63 $223,657 Sale
MAURO DAVID J officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 24,586 $10.08 $247,827 Purchase
ADAGE CAPITAL PARTNERS GP LLC
Common Stock 50,000 $13.81 $690,300 Purchase
ADAGE CAPITAL PARTNERS GP LLC
Common Stock 75,000 $14.21 $1,065,750 Purchase
ADAGE CAPITAL PARTNERS GP LLC
Common Stock 71,182 $14.27 $1,015,554