Option
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 60,651 $0.2 $11,888 Option
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 60,651 $0.2 $11,888 Sale
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 22,695 $13.01 $295,217 Sale
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 7,305 $13 $94,965 Option
GOLDBERG MURRAY A director director
Stock Option (right to buy) 28,000 $3.15 $88,200 Option
GOLDBERG MURRAY A director director
Common Stock 28,000 $3.15 $88,200 Sale
CAGLE GERALD D. director director
Common Stock 5,000 $15.27 $76,350 Sale
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 1,000,000 $17.07 $17,070,000 Option
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 117,000 $0.41 $47,385 Option
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 117,000 $0.41 $47,385 Purchase
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 26,250 $19.44 $510,300 Purchase
RUBINO RICHARD J officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,040 $19.93 $100,447 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 15,700 $18.42 $289,194 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 100,200 $18.48 $1,851,696 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 50,000 $21 $1,049,750 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 25,000 $21.36 $534,000 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 38,300 $23.42 $896,986 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 6,700 $23.68 $158,656 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 1,153 $23.25 $26,807 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 50,000 $23.21 $1,160,500 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 3,847 $23.34 $89,789 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 100,000 $24.23 $2,423,000 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 100,000 $23.73 $2,373,000 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 250,000 $25.22 $6,305,000 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 189,555 $24.43 $4,630,829 Sale
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 11,000 $46.53 $511,797 Sale
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 11,000 $35.21 $387,310 Sale
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 11,000 $40.17 $441,837 Purchase
CAGLE GERALD D. director director
Common Stock 2,000 $41.75 $83,494 Sale
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 11,000 $53.61 $589,699 Sale
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 11,000 $60.88 $669,702 Sale
RUBINO RICHARD J officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 16,605 $60.69 $1,007,708 Sale
RUBINO RICHARD J officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 50,000 $60.6 $3,029,750 Sale
RUBINO RICHARD J officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 2 $60 $120 Sale
RUBINO RICHARD J officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 34,512 $60.17 $2,076,622 Sale
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 11,000 $60.5 $665,511 Option
MITRO THOMAS A officer: President and COO officer: President and COO
Option (Right to Buy) 190,000 $3.15 $598,500 Option
MITRO THOMAS A officer: President and COO officer: President and COO
Common Stock 190,000 $3.15 $598,500 Sale
MITRO THOMAS A officer: President and COO officer: President and COO
Common Stock 190,000 $60.64 $11,520,840 Sale
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 11,000 $68.34 $751,784 Sale
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 11,000 $66.62 $732,809 Sale
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 50,000 $62.41 $3,120,600 Option
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Option (Right to Buy) 50,000 $3.15 $157,500 Option
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 50,000 $3.15 $157,500 Option
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Option (Right to Buy) 50,000 $3.03 $151,250 Option
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 50,000 $3.03 $151,250 Sale
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 50,000 $63.94 $3,196,750 Sale
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 50,000 $62.43 $3,121,500 Option
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 50,000 $2.9 $145,000 Option
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Option (Right to Buy) 50,000 $2.9 $145,000