Sale
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 11,000 $58.89 $647,834 Sale
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 50,000 $60.77 $3,038,550 Option
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Option (Right to Buy) 50,000 $2.9 $145,000 Option
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 50,000 $2.9 $145,000 Sale
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,708 $50.15 $135,806 Purchase
CAGLE GERALD D. director director
Common Stock 1,000 $49.45 $49,450 Option
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Warrant (right to buy) 3,000 $5 $15,000 Option
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 3,000 $5 $15,000 Purchase
CAGLE GERALD D. director director
Common Stock 1,000 $50.25 $50,245 Option
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 3,251 $0.4 $1,284 Option
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 3,251 $0.4 $1,284 Sale
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 20,000 $55.95 $1,119,000 Purchase
CAGLE GERALD D. director director
Common Stock 1,000 $39.9 $39,900 Purchase
CAGLE GERALD D. director director
Common Stock 2,000 $41.8 $83,600 Sale
DUYK GEOFFREY M director director
Common Stock 20,796 $46.81 $973,440 Option
DUYK GEOFFREY M director director
Common Stock 58,167 $18.13 $1,054,277 Option
DUYK GEOFFREY M director director
Stock Option (right to buy) 16,667 $25.9 $431,675 Sale
DUYK GEOFFREY M director director
Common Stock 20,795 $46.46 $966,053 Sale
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 50,000 $40.34 $2,017,000 Purchase
FORESITE CAPITAL MANAGEMENT II, LLC 10 percent owner 10 percent owner
Common Stock 250,000 $17.5 $4,375,000 Purchase
CAGLE GERALD D. director director
Common Stock 2,000 $16.6 $33,200 Purchase
CAGLE GERALD D. director director
Common Stock 500 $15.46 $7,730 Purchase
CAGLE GERALD D. director director
Common Stock 1,146 $16.36 $18,749 Option
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 4,596 $0.01 $23 Option
KOPCZYNSKI CASEY C. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 4,596 $0.01 $23 Sale
MEHRA ANAND director director
Common Stock 294,298 $33.45 $9,843,974 Sale
MEHRA ANAND director director
Common Stock 130,702 $34.08 $4,453,932 Purchase
CAGLE GERALD D. director director
Common Stock 500 $15.46 $7,730 Purchase
CAGLE GERALD D. director director
Common Stock 500 $15.46 $7,730 Sale
CLARUS LIFESCIENCES II, L.P. 10 percent owner 10 percent owner
Common Stock 175,000 $31.11 $5,444,250 Sale
CLARUS LIFESCIENCES II, L.P. 10 percent owner 10 percent owner
Common Stock 23,620 $30.89 $729,622 Sale
CLARUS LIFESCIENCES II, L.P. 10 percent owner 10 percent owner
Common Stock 6,214 $30.03 $186,606 Sale
CLARUS LIFESCIENCES II, L.P. 10 percent owner 10 percent owner
Common Stock 74,510 $30.05 $2,239,026 Sale
CLARUS LIFESCIENCES II, L.P. 10 percent owner 10 percent owner
Common Stock 263 $30 $7,890 Sale
CLARUS LIFESCIENCES II, L.P. 10 percent owner 10 percent owner
Common Stock 49,441 $30.36 $1,501,029 Sale
TPG GROUP HOLDINGS (SBS) ADVISORS, INC. other: Former 10% .. other: Former 10% Owner (2)(3)(4)
Common Stock 1,300,000 $25.97 $33,761,000 Sale
MEHRA ANAND director director
Common Stock 800,000 $26 $20,800,000 Sale
SOFINNOVA VENTURE PARTNERS VII L P 10 percent owner 10 percent owner
Common Stock 8,022 $25.81 $207,032 Sale
MEHRA ANAND director director
Common Stock 8,022 $25.81 $207,032 Sale
TPG GROUP HOLDINGS (SBS) ADVISORS, INC. other: Former 10% .. other: Former 10% Owner (2)(3)(4)
Common Stock 500,000 $25.28 $12,640,000 Sale
SOFINNOVA VENTURE PARTNERS VII L P 10 percent owner 10 percent owner
Common Stock 1,000,000 $24 $24,001,000 Sale
MEHRA ANAND director director
Common Stock 1,000,000 $24 $24,001,000 Sale
TPG GROUP HOLDINGS (SBS) ADVISORS, INC. other: Former 10% .. other: Former 10% Owner (2)(3)(4)
Common Stock 500,000 $25.28 $12,640,000 Sale
MEHRA ANAND director director
Common Stock 323,932 $16 $5,182,912 Sale
ACP IV, L.P. 10 percent owner 10 percent owner
Common Stock 300,000 $16 $4,800,000 Purchase
CAGLE GERALD D. director director
Common Stock 1,854 $15.07 $27,940 Purchase
ACP IV, L.P. 10 percent owner 10 percent owner
Common Stock 110,000 $10 $1,100,000 Purchase
TPG GROUP HOLDINGS (SBS) ADVISORS, INC. other: Former 10% .. other: Former 10% Owner (2)(3)(4)
Common Stock 284,000 N/A N/A Purchase
ANIDO VICENTE JR director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 28,000 $10 $280,000 Purchase
RUBINO RICHARD J officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 10,000 $10 $100,000