Option
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Stock Option (Right to Buy) 4,777 $7.1 $33,917 Option
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Common Stock 4,777 $7.1 $33,917 Sale
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Common Stock 4,777 $7.1 $33,917 Option
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Common Stock 2,400 $7.1 $17,040 Option
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Stock Option (Right to Buy) 2,400 $7.1 $17,040 Sale
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Common Stock 2,400 $7.1 $17,040 Sale
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Common Stock 2,823 $7.1 $20,043 Option
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Common Stock 2,823 $7.1 $20,043 Option
MASON MICHAEL officer: VP, Finance and Treasurer officer: VP, Finance and Treasu..
Stock Option (Right to Buy) 3,750 $7.1 $26,625 Option
MASON MICHAEL officer: VP, Finance and Treasurer officer: VP, Finance and Treasu..
Common Stock 3,750 $7.1 $26,625 Sale
MASON MICHAEL officer: VP, Finance and Treasurer officer: VP, Finance and Treasu..
Common Stock 3,750 $7.1 $26,625 Option
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Stock Option (Right to Buy) 2,823 $7.1 $20,043 Sale
NOVARTIS AG 10 percent owner 10 percent owner
Common Stock 1,551,896 $19.42 $30,137,820 Sale
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Common Stock 4,916 $19 $93,404 Option
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Stock Option (Right to Buy) 4,916 $19 $93,404 Option
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Common Stock 4,916 $19 $93,404 Option
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Stock Option (Right to Buy) 1,334 $9.3 $12,406 Option
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Common Stock 1,334 $9.3 $12,406 Sale
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Common Stock 1,334 $9.3 $12,406 Sale
MASON MICHAEL officer: VP, Finance and Treasurer officer: VP, Finance and Treasu..
Common Stock 6,250 $10.98 $68,625 Option
MASON MICHAEL officer: VP, Finance and Treasurer officer: VP, Finance and Treasu..
Stock Option (Right to Buy) 6,250 $10.98 $68,625 Option
MASON MICHAEL officer: VP, Finance and Treasurer officer: VP, Finance and Treasu..
Common Stock 6,250 $10.98 $68,625 Sale
MASON MICHAEL officer: VP, Finance and Treasurer officer: VP, Finance and Treasu..
Common Stock 8,733 $19 $165,927 Sale
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Common Stock 25,000 $19 $475,000 Option
MASON MICHAEL officer: VP, Finance and Treasurer officer: VP, Finance and Treasu..
Common Stock 15,295 $14.07 $215,201 Option
MASON MICHAEL officer: VP, Finance and Treasurer officer: VP, Finance and Treasu..
Stock Option (Right to Buy) 15,295 $14.07 $215,201 Option
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Common Stock 36,250 $14.07 $510,038 Option
VAISHNAW AKSHAY officer: President, R&D officer: President, R&D
Stock Option (Right to Buy) 36,250 $14.07 $510,038 Purchase
GREENE BARRY E officer: President officer: President
Common Stock 1,860 $10.75 $19,995 Purchase
SHARP PHILIP A
Common Stock 9,302 $10.75 $99,997 Purchase
MARAGANORE JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 5,581 $10.75 $59,996 Purchase
REID LAURENCE officer: SVP, Chief Business Officer officer: SVP, Chief Business Of..
Common Stock 930 $10.75 $9,998 Purchase
FANUCCI MARSHA director director
Common Stock 10,000 $10.75 $107,500 Purchase
SCHIMMEL PAUL director director
Common Stock 93,023 $10.75 $999,997 Purchase
MARAGANORE JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 1,134 $8.81 $9,995 Purchase
GREENE BARRY E officer: President officer: President
Common Stock 567 $8.8 $4,992 Purchase
GREENE BARRY E officer: President officer: President
Common Stock 699 $7.15 $4,995 Purchase
MARAGANORE JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 1,397 $7.16 $9,996 Purchase
GREENE BARRY E officer: President officer: President
Common Stock 704 $7.09 $4,994 Purchase
MARAGANORE JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 1,411 $7.09 $9,997 Purchase
MARAGANORE JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 1,480 $6.75 $9,989 Purchase
GREENE BARRY E officer: President officer: President
Common Stock 742 $6.73 $4,996 Option
MARAGANORE JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to buy) 50,000 $0.48 $23,750 Option
MARAGANORE JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 50,000 $0.48 $23,750 Sale
VINCENT JAMES L director director
Common Stock 8,667 $15.16 $131,392 Option
VINCENT JAMES L director director
Common Stock 12,100 $7.02 $84,942 Option
VINCENT JAMES L director director
Non-Qualified Stock Option (right to buy) 12,100 $7.02 $84,942 Sale
VINCENT JAMES L director director
Common Stock 1,333 $15.7 $20,931 Option
VINCENT JAMES L director director
Non-Qualified Stock Option (right to buy) 30,000 $7.02 $210,600 Option
VINCENT JAMES L director director
Common Stock 30,000 $7.02 $210,600