Option
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Employee Stock Option (Right to Buy) 41,728 $1.12 $46,735 Sale
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Common Stock 41,728 $69.69 $2,908,108 Option
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Common Stock 41,728 $1.12 $46,735 Option
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Employee Stock Option 30,000 $1.12 $33,600 Option
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Common Stock 30,000 $1.12 $33,600 Sale
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Common Stock 30,000 $71.97 $2,159,040 Sale
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Common Stock 4,998 $70.83 $354,008 Option
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Employee Stock Option (Right to Buy) 30,587 $1.12 $34,257 Option
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Common Stock 30,587 $1.12 $34,257 Sale
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Common Stock 30,587 $71.52 $2,187,429 Sale
PISCITELLI DOMINIC officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 37,000 $72.87 $2,696,227 Option
PISCITELLI DOMINIC officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 37,000 $11.34 $419,580 Option
PISCITELLI DOMINIC officer: Chief Financial Officer officer: Chief Financial Officer
Employee Stock Option (Right to Buy) 37,000 $11.34 $419,580 Option
LONDEI MARCO officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 142,857 $0.7 $100,000 Option
LONDEI MARCO officer: Chief Medical Officer officer: Chief Medical Officer
Employee Stock Option (right to buy) 142,857 $0.7 $100,000 Option
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Common Stock 7,636 $1.93 $14,699 Option
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Employee Stock Option (right to buy) 1,428 $2.24 $3,199 Option
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Employee Stock Option (right to buy) 22,428 $2.59 $58,089 Option
SURIA HAMZA director, officer: President, CEO director, officer: President, CEO
Common Stock 22,428 $2.59 $58,089 Sale
LYDON NICHOLAS director director
Common Stock 33,000 $87.27 $2,879,877 Option
LYDON NICHOLAS director director
Common Stock 16,483 $4.55 $74,998 Option
LYDON NICHOLAS director director
Series C Preferred Stock Warrant (right to buy) 16,483 $4.55 $74,998 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 356,300 $21.1 $7,518,286 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 143,428 $21 $3,011,988 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 35,172 $21.79 $766,503 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 481,023 $22.01 $10,586,354 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 10,271 $22 $225,962 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 21,451 $22.01 $472,201 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 25,700 $23.87 $613,485 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 23,555 $23.87 $562,281 Sale
AVALON VENTURES VII L P 10 percent owner 10 percent owner
Common Stock 37,040 $24.35 $901,924 Purchase
FRAZIER HEALTHCARE V, LP 10 percent owner 10 percent owner
Common Stock 400,000 $15 $6,000,000 Purchase
TOPPER JAMES N director, 10 percent owner director, 10 percent owner
Common Stock 400,000 $15 $6,000,000 Purchase
FRAZIER HEALTHCARE VII, L.P. 10 percent owner 10 percent owner
Common Stock 400,000 $15 $6,000,000 Purchase
FRAZIER HEALTHCARE V, LP 10 percent owner 10 percent owner
Common Stock 400,000 $15 $6,000,000 Purchase
NOVO A/S
Common Stock 50,000 $15 $750,000 Purchase
TOPPER JAMES N director, 10 percent owner director, 10 percent owner
Common Stock 400,000 $15 $6,000,000 Purchase
LYDON NICHOLAS director director
Common Stock 16,666 $15 $249,990