Purchase
SANDELL SCOTT D 10 percent owner 10 percent owner
Common Stock 2,290,951 $8.73 $20,000,002 Purchase
MAKOWER JOSHUA 10 percent owner 10 percent owner
Common Stock 1,527,301 $8.73 $13,333,338 Purchase
MOTT DAVID M director director
Common Stock 1,527,301 $8.73 $13,333,338 Purchase
BARRETT M JAMES 10 percent owner 10 percent owner
Common Stock 763,650 $8.73 $6,666,665 Purchase
BARRIS PETER J 10 percent owner 10 percent owner
Common Stock 2,290,951 $8.73 $20,000,002 Purchase
RINGOLD GORDON director director
Common Stock 15,000 $7.77 $116,535 Sale
ROSENBAUM DAVID P. officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 1,128 $10.74 $12,110 Option
KAUFMANN MARK officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,000 $0.54 $2,700 Option
KAUFMANN MARK officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (Right to Buy) 5,000 $0.54 $2,700 Sale
KAUFMANN MARK officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,000 $0.54 $2,700 Purchase
FLORENCE ANTHONY A. JR. 10 percent owner 10 percent owner
Common Stock 500,000 $10 $5,000,000 Purchase
SANDELL SCOTT D 10 percent owner 10 percent owner
Common Stock 1,000,000 $10 $10,000,000 Purchase
SONSINI PETER W. 10 percent owner 10 percent owner
Common Stock 500,000 $10 $5,000,000 Purchase
KOLLURI KRISHNA KITTU 10 percent owner 10 percent owner
Common Stock 1,000,000 $10 $10,000,000 Purchase
VISWANATHAN RAVI 10 percent owner 10 percent owner
Common Stock 500,000 $10 $5,000,000 Purchase
BARRETT M JAMES 10 percent owner 10 percent owner
Common Stock 500,000 $10 $5,000,000 Purchase
KERINS PATRICK J 10 percent owner 10 percent owner
Common Stock 500,000 $10 $5,000,000 Purchase
MOTT DAVID M director director
Common Stock 500,000 $10 $5,000,000 Purchase
MAKOWER JOSHUA 10 percent owner 10 percent owner
Common Stock 500,000 $10 $5,000,000 Purchase
NEA 15 GP, LLC 10 percent owner 10 percent owner
Common Stock 500,000 $10 $5,000,000 Purchase
SAKODA JON 10 percent owner 10 percent owner
Common Stock 500,000 $10 $5,000,000 Purchase
NEW ENTERPRISE ASSOCIATES 12, LIMITED PARTNERSHIP 10 perce.. 10 percent owner
Common Stock 500,000 $10 $5,000,000 Purchase
WELLER HARRY R 10 percent owner 10 percent owner
Common Stock 500,000 $10 $5,000,000 Purchase
BASKETT FOREST 10 percent owner 10 percent owner
Common Stock 1,000,000 $10 $10,000,000 Purchase
BARRIS PETER J 10 percent owner 10 percent owner
Common Stock 1,000,000 $10 $10,000,000 Purchase
BERTRAND WILLIAM C JR director director
Common Stock 5,000 $20 $100,000 Option
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 2,000 $0.54 $1,080 Sale
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 $0.54 $1,080 Option
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 $0.54 $1,080 Sale
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 $0.54 $1,080 Option
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 2,000 $0.54 $1,080 Option
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 $0.54 $1,080 Option
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 2,000 $0.54 $1,080 Option
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 $0.54 $1,080 Sale
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 $0.54 $1,080 Sale
ROSENBAUM DAVID P. officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 1,200 $22 $26,400 Sale
ROSENBAUM DAVID P. officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 1,600 $22.09 $35,349 Sale
ROSENBAUM DAVID P. officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 5,080 $22.01 $111,796 Option
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 $0.54 $1,080 Option
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 2,000 $0.54 $1,080 Sale
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 $0.54 $1,080 Sale
RAAB MICHAEL director, officer: President & CEO director, officer: President & ..
Common Stock 9,785 $20.29 $198,547 Sale
ROSENBAUM DAVID P. officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 1,251 $19.25 $24,082 Sale
GRAMMER ELIZABETH A officer: See Remarks officer: See Remarks
Common Stock 893 $18.32 $16,360 Sale
CALDWELL JEREMY S officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 643 $18.32 $11,780 Sale
ROSENBAUM DAVID P. officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 1,286 $18.32 $23,560 Sale
RAAB MICHAEL director, officer: President & CEO director, officer: President & ..
Common Stock 1,104 $20 $22,080 Sale
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 $0.54 $1,080 Option
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 $0.54 $1,080 Option
JACOBS JEFFREY W officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 2,000 $0.54 $1,080