Purchase
DALAL ANUPAM director director
Common Stock 1,529,402 $13.08 $19,999,990 Purchase
CASTELEIN CALEY director director
Common Stock 259,998 $13.08 $3,399,994 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 21,400 $0.96 $20,544 Purchase
GARDNER JOSEPH H. director, officer: President director, officer: President
Common Stock 5,000 N/A N/A Purchase
GARDNER JOSEPH H. director, officer: President director, officer: President
Common Stock 5,000 N/A N/A Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 138,704 N/A N/A Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 563,096 $1.03 $579,989 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 16,403 N/A N/A Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 27,554 $1.03 $28,381 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 7,100 N/A N/A Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 28,794 N/A N/A Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 30,908 N/A N/A Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 57,438 $1.08 $62,033 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 140,230 $1.09 $152,851 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 32,991 $1.01 $33,321 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 27,525 $1.02 $28,076 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 24,661 $1.02 $25,154 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 47,900 N/A N/A Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 58,033 N/A N/A Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 51,754 $0.97 $50,201 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 116,909 $0.95 $111,064 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 63,100 $0.91 $57,421 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 88,835 $0.94 $83,505 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 50,749 $0.99 $50,242 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 177,762 $1.01 $179,540 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 23,818 N/A N/A Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $2.39 $47,880 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $2.39 $47,880 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 N/A N/A Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 N/A N/A Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 N/A N/A Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $1.94 $38,840 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $1.94 $38,840 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 N/A N/A Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $1.67 $33,420 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 N/A N/A Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 N/A N/A Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 N/A N/A Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 N/A N/A Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 N/A N/A Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 N/A N/A Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $2.01 $40,100 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $2.01 $40,100 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $2.09 $41,840 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $2.09 $41,840 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $2.09 $41,840 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $2.18 $43,580 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $2.18 $43,580 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $2.18 $43,580 Purchase
SATTER MUNEER A director, 10 percent owner director, 10 percent owner
Common Stock 20,000 $1.99 $39,700