Option
HATZIS-SCHOCH BRENT officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 4,078 $3.2 $13,050 Option
HATZIS-SCHOCH BRENT officer: See Remarks officer: See Remarks
Common Stock 4,078 $3.2 $13,050 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 15,598 $34.34 $535,635 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 15,598 $34.34 $535,635 Option
ROBERTS CHRISTOPHER D. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 5,000 $10.86 $54,300 Sale
ROBERTS CHRISTOPHER D. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 5,000 $10.86 $54,300 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 12,617 $34.4 $434,000 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 12,617 $34.4 $434,000 Option
ROBERTS CHRISTOPHER D. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 5,000 $10.86 $54,300 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 26,966 $33.81 $911,747 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 26,966 $33.81 $911,747 Option
LEGGETT THOMAS officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (Right to Buy) 3,000 $10.86 $32,580 Sale
LEGGETT THOMAS officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 3,000 $10.86 $32,580 Option
LEGGETT THOMAS officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 3,000 $10.86 $32,580 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 6,300 $33.06 $208,253 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 6,300 $33.06 $208,253 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 3,100 $33.13 $102,700 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 3,100 $33.13 $102,700 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 8,848 $33.15 $293,285 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 8,848 $33.15 $293,285 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 2,500 $33.14 $82,840 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 2,500 $33.14 $82,840 Option
ROBERTS CHRISTOPHER D. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 $10.86 $27,150 Option
ROBERTS CHRISTOPHER D. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 2,500 $10.86 $27,150 Sale
ROBERTS CHRISTOPHER D. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 $10.86 $27,150 Option
EPSTEIN DAVID M. director, officer: See Remarks director, officer: See Remarks
Stock Option (Right to Buy) 3,000 $6.42 $19,260 Sale
EPSTEIN DAVID M. director, officer: See Remarks director, officer: See Remarks
Common Stock 12,000 $31.5 $378,048 Option
EPSTEIN DAVID M. director, officer: See Remarks director, officer: See Remarks
Common Stock 3,000 $6.42 $19,260 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 800 $33.03 $26,426 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 800 $33.03 $26,426 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 8,103 $33.31 $269,870 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 8,103 $33.31 $269,870 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 4,233 $33.43 $141,513 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 4,233 $33.43 $141,513 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 8,713 $33.57 $292,522 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 8,713 $33.57 $292,522 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 2,800 $33.03 $92,495 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 2,800 $33.03 $92,495 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 5,501 $33.09 $182,034 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 5,501 $33.09 $182,034 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 11,739 $33.39 $391,989 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 11,739 $33.39 $391,989 Option
HATZIS-SCHOCH BRENT officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 4,078 $3.2 $13,050 Sale
HATZIS-SCHOCH BRENT officer: See Remarks officer: See Remarks
Common Stock 4,078 $33.18 $135,320 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 400 $33.11 $13,243 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 400 $33.11 $13,243 Option
HATZIS-SCHOCH BRENT officer: See Remarks officer: See Remarks
Common Stock 4,078 $3.2 $13,050 Sale
BOLZON BRADLEY J PHD director, 10 percent owner director, 10 percent owner
Common Stock 3,800 $33.67 $127,935 Sale
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 3,800 $33.67 $127,935 Option
LEGGETT THOMAS officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (Right to Buy) 3,000 $10.86 $32,580