| Utility: Phenylacetamides as inhibitors of rock Filling date: 6 Sep 2025 Issue date: 19 Apr 2022 | 11 Jul 2018 | 19 Apr 2022 |
| Utility: Method of identifying a P-selectin glycoprotein ligand-1 (PSGL-1) antagonist Filling date: 6 Sep 2025 Issue date: 19 Apr 2022 | 10 Jan 2018 | 19 Apr 2022 |
| Utility: Combination of TIM-4 antagonist and PD-1 antagonist and methods of use Filling date: 6 Sep 2025 Issue date: 19 Apr 2022 | 5 Jul 2017 | 19 Apr 2022 |
| Utility: Diazaindole compounds Filling date: 6 Sep 2025 Issue date: 12 Apr 2022 | 18 Dec 2018 | 12 Apr 2022 |
| Utility: Five membered-aminoheterocycle and 5,6-or 6,6-membered bicyclic aminoheterocyclic inhibitors of rock for the treatment of heart failure Filling date: 6 Sep 2025 Issue date: 12 Apr 2022 | 11 Jul 2018 | 12 Apr 2022 |
| Utility: Substituted imidazo[1,2-b]pyridazines as interleukin-23 and interferon-.alpha. modulators Filling date: 6 Sep 2025 Issue date: 12 Apr 2022 | 16 Nov 2017 | 12 Apr 2022 |
| Utility: Use of an anti-PD-1 antibody in combination with an anti-CD30 antibody in cancer treatment Filling date: 6 Sep 2025 Issue date: 12 Apr 2022 | 1 Jun 2017 | 12 Apr 2022 |
| Utility: ANTIBODIES COMPRISING MODIFIED HEAVY CONSTANT REGIONS Filling date: 6 Sep 2025 Issue date: 7 Apr 2022 | 26 Nov 2019 | 7 Apr 2022 |
| Utility: Substituted tetrahydropyrrolo[1,2-a]pyrazines as alpha v integrin inhibitors Filling date: 6 Sep 2025 Issue date: 5 Apr 2022 | 5 Nov 2018 | 5 Apr 2022 |
| Utility: COMBINATION OF DR5 AGONIST AND ANTI-PD-1 ANTAGONIST AND METHODS OF USE Filling date: 6 Sep 2025 Issue date: 31 Mar 2022 | 28 Jul 2021 | 31 Mar 2022 |
| Utility: Alkene spirocyclic compounds as farnesoid X receptor modulators Filling date: 6 Sep 2025 Issue date: 29 Mar 2022 | 31 Oct 2018 | 29 Mar 2022 |
| Utility: ANTIBODIES AGAINST TIM3 AND USES THEREOF Filling date: 6 Sep 2025 Issue date: 24 Mar 2022 | 11 Jan 2019 | 24 Mar 2022 |
| Utility: Fibronectin binding domains with reduced immunogenicity Filling date: 6 Sep 2025 Issue date: 22 Mar 2022 | 25 Sep 2019 | 22 Mar 2022 |
| Utility: SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS Filling date: 6 Sep 2025 Issue date: 17 Mar 2022 | 14 Feb 2020 | 17 Mar 2022 |
| Utility: Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors Filling date: 6 Sep 2025 Issue date: 15 Mar 2022 | 11 Sep 2020 | 15 Mar 2022 |
| Utility: Anti-human natural killer cell inhibitory receptor group 2A protein (NKG2A) antibodies Filling date: 6 Sep 2025 Issue date: 15 Mar 2022 | 14 Nov 2019 | 15 Mar 2022 |
| Utility: ANTIBODY POLYPEPTIDES THAT ANTAGONIZE CD40L Filling date: 6 Sep 2025 Issue date: 10 Mar 2022 | 9 Nov 2021 | 10 Mar 2022 |
| Utility: Methods of treating systemic lupus erythematosus using a domain antibody directed against CD28 Filling date: 6 Sep 2025 Issue date: 8 Mar 2022 | 8 Apr 2020 | 8 Mar 2022 |
| Utility: Cyclohexyl acid triazole azines as LPA antagonists Filling date: 6 Sep 2025 Issue date: 8 Mar 2022 | 18 Dec 2018 | 8 Mar 2022 |
| Utility: Small molecule inhibitors of galectin-3 Filling date: 6 Sep 2025 Issue date: 8 Mar 2022 | 27 Sep 2018 | 8 Mar 2022 |
| Utility: PROCESS FOR THE PREPARATION OF A CYCLIC DINUCLEOTIDE Filling date: 6 Sep 2025 Issue date: 3 Mar 2022 | 3 Dec 2019 | 3 Mar 2022 |
| Utility: SUBSTITUTED THIENOPYRROLES AS PAD4 INHIBITORS Filling date: 6 Sep 2025 Issue date: 3 Mar 2022 | 7 Aug 2019 | 3 Mar 2022 |
| Utility: Antagonistic CD40 monoclonal antibodies and uses thereof Filling date: 6 Sep 2025 Issue date: 1 Mar 2022 | 18 Nov 2019 | 1 Mar 2022 |
| Utility: Cyclohexyl acid isoxazole azoles as LPA antagonists Filling date: 6 Sep 2025 Issue date: 1 Mar 2022 | 18 Dec 2018 | 1 Mar 2022 |
| Utility: Pyrazole O-linked carbamoyl cyclohexyl acids as LPA antagonists Filling date: 6 Sep 2025 Issue date: 1 Mar 2022 | 18 Dec 2018 | 1 Mar 2022 |
| Utility: Antagonistic CD40 monoclonal antibodies and uses in treating immune responses Filling date: 6 Sep 2025 Issue date: 22 Feb 2022 | 26 Oct 2020 | 22 Feb 2022 |
| Utility: Substituted bicyclic compounds as farnesoid X receptor modulators Filling date: 6 Sep 2025 Issue date: 22 Feb 2022 | 13 Feb 2020 | 22 Feb 2022 |
| Utility: Inhibitors of indoleamine 2,3-dioxygenase and methods of their use Filling date: 6 Sep 2025 Issue date: 22 Feb 2022 | 29 Aug 2019 | 22 Feb 2022 |
| Utility: Methods of treatment using IL-23p19 monoclonal antibodies Filling date: 6 Sep 2025 Issue date: 22 Feb 2022 | 10 Jun 2019 | 22 Feb 2022 |
| Utility: Process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1- ,3,5]triazin-4-ylamino)-2-oxopyrroldin-1-yl)cyclohexyl)acetamide Filling date: 6 Sep 2025 Issue date: 22 Feb 2022 | 19 Jul 2018 | 22 Feb 2022 |
| Utility: SYNTHETIC PROCESS Filling date: 6 Sep 2025 Issue date: 17 Feb 2022 | 12 Aug 2020 | 17 Feb 2022 |
| Utility: Methods of treating diseases associated with fibrosis using modified FGF-21 polypeptides Filling date: 6 Sep 2025 Issue date: 15 Feb 2022 | 28 Jun 2019 | 15 Feb 2022 |
| Utility: METHODS OF MEASURING HYDROPHOBICITY OF CHROMATOGRAPHIC RESINS Filling date: 6 Sep 2025 Issue date: 10 Feb 2022 | 27 Mar 2020 | 10 Feb 2022 |
| Utility: Antibodies against MICA and/or MICB and uses thereof Filling date: 6 Sep 2025 Issue date: 8 Feb 2022 | 22 Mar 2019 | 8 Feb 2022 |
| Utility: ANTIBODIES MODIFIED FOR TRANSGLUTAMINASE CONJUGATION, CONJUGATES THEREOF, AND METHODS AND USES Filling date: 6 Sep 2025 Issue date: 3 Feb 2022 | 10 Dec 2019 | 3 Feb 2022 |
| Utility: BARCODED PEPTIDE-MHC COMPLEXES AND USES THEREOF Filling date: 6 Sep 2025 Issue date: 3 Feb 2022 | 23 Sep 2019 | 3 Feb 2022 |
| Utility: Amorphous and crystalline forms of IDO inhibitors Filling date: 6 Sep 2025 Issue date: 1 Feb 2022 | 29 Jun 2018 | 1 Feb 2022 |
| Utility: Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation Filling date: 6 Sep 2025 Issue date: 1 Feb 2022 | 29 Jun 2018 | 1 Feb 2022 |
| Utility: TREATMENT OF HODGKIN LYMPHOMA USING AN ANTI-PD-1 ANTIBODY Filling date: 6 Sep 2025 Issue date: 27 Jan 2022 | 9 Aug 2021 | 27 Jan 2022 |
| Utility: CLASSIFYING PHARMACOVIGILANCE DOCUMENTS USING IMAGE ANALYSIS Filling date: 6 Sep 2025 Issue date: 27 Jan 2022 | 11 Jun 2021 | 27 Jan 2022 |
| Utility: DEVICES AND SYSTEMS FOR DELIVERY OF COMBINATION THERAPIES Filling date: 6 Sep 2025 Issue date: 27 Jan 2022 | 10 May 2019 | 27 Jan 2022 |
| Utility: Methods and compositions for 18F-radiolabeling of biologics Filling date: 6 Sep 2025 Issue date: 25 Jan 2022 | 24 Nov 2015 | 25 Jan 2022 |
| Utility: TREATMENT OF LUNG CANCER USING A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-CTLA-4 ANTIBODY Filling date: 6 Sep 2025 Issue date: 20 Jan 2022 | 26 Jul 2021 | 20 Jan 2022 |
| Utility: FGF-21 CONJUGATE FORMULATIONS Filling date: 6 Sep 2025 Issue date: 20 Jan 2022 | 7 Jan 2021 | 20 Jan 2022 |
| Utility: ANTIBODY COMPRISING A GLUTAMINE-CONTAINING LIGHT CHAIN C-TERMINAL EXTENSION, CONJUGATES THEREOF, AND METHODS AND USES Filling date: 6 Sep 2025 Issue date: 20 Jan 2022 | 25 Nov 2019 | 20 Jan 2022 |
| Utility: Modified relaxin polypeptides comprising a pharmacokinetic enhancer and pharmaceutical compositions thereof Filling date: 6 Sep 2025 Issue date: 18 Jan 2022 | 11 Mar 2021 | 18 Jan 2022 |
| Utility: SMALL MOLECULE INHIBITORS OF GALECTIN-3 Filling date: 6 Sep 2025 Issue date: 13 Jan 2022 | 4 Dec 2019 | 13 Jan 2022 |
| Utility: Treatment of C1013G/CXCR4-associated Waldenstrom's macroglobulinemia with an anti-CXCR4 antibody Filling date: 6 Sep 2025 Issue date: 11 Jan 2022 | 8 Feb 2019 | 11 Jan 2022 |
| Utility: Antagonistic anti-CD40 antibodies and methods of antagonizing CD40 activity Filling date: 6 Sep 2025 Issue date: 11 Jan 2022 | 24 May 2018 | 11 Jan 2022 |
| Utility: Process for preparing indole carboxamide compounds Filling date: 6 Sep 2025 Issue date: 11 Jan 2022 | 31 Aug 2017 | 11 Jan 2022 |
