Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 11,000 $1.01 $11,110 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 11,000 $1.01 $11,110 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 10,300 $19.54 $201,211 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 700 $20.33 $14,229 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 11,000 $1.01 $11,110 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 11,000 $1.01 $11,110 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 7,868 $21.76 $171,200 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 3,132 $22.22 $69,593 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 11,000 $1.01 $11,110 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 11,000 $1.01 $11,110 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 3,542 $17.39 $61,610 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 7,458 $18.02 $134,408 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 11,000 $1.01 $11,110 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 11,000 $1.01 $11,110 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 10,592 $13.32 $141,096 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 408 $14.28 $5,825 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 11,000 $1.01 $11,110 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 11,000 $1.01 $11,110 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 10,300 $17.5 $180,271 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 700 $18.5 $12,950 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 11,000 $1.01 $11,110 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 11,000 $1.01 $11,110 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 10,700 $13.41 $143,434 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 300 $13.82 $4,147 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 11,000 $1.01 $11,110 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 11,000 $1.01 $11,110 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 8,185 $13.67 $111,881 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 2,815 $14.26 $40,142 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 11,000 $1.01 $11,110 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 11,000 $1.01 $11,110 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 11,000 $12.99 $142,923 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 22,000 $1.01 $22,220 Sale
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Common Stock 22,000 $11.81 $259,842 Option
BINDER GWENDOLYN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 22,000 $1.01 $22,220 Purchase
NICHTBERGER STEVEN director, officer: President & CEO director, officer: President & ..
Common Stock 8,127 $1.25 $10,151 Purchase
NICHTBERGER STEVEN director, officer: President & CEO director, officer: President & ..
Common Stock 141,873 $0.99 $141,022 Purchase
BINDER GWENDOLYN officer: President, Science & Technology officer: President, Science & T..
Common Stock 20,000 $1 $19,900 Purchase
SIMON MARK director director
Common Stock 7,000 $0.98 $6,832 Purchase
SIMON MARK director director
Common Stock 118,000 $0.98 $115,286 Purchase
MARDA ANUP officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 50,000 $0.99 $49,600 Purchase
BOLLARD CATHERINE director director
Common Stock 1,000 $0.99 $994 Option
NICHTBERGER STEVEN director, officer: President & CEO director, officer: President & ..
Stock Option (Right to Buy) 50,000 $1.01 $50,500 Option
NICHTBERGER STEVEN director, officer: President & CEO director, officer: President & ..
Common Stock 50,000 $1.01 $50,500 Sale
5AM VENTURES V, L.P. 10 percent owner 10 percent owner
Common Stock 295,000 $13 $3,835,000 Sale
5AM VENTURES V, L.P. 10 percent owner 10 percent owner
Common Stock 625,000 $9.7 $6,062,500 Sale
5AM VENTURES V, L.P. 10 percent owner 10 percent owner
Common Stock 85,000 $13 $1,105,000 Sale
5AM VENTURES V, L.P. 10 percent owner 10 percent owner
Common Stock 85,000 $13 $1,105,000 Sale
5AM VENTURES V, L.P. 10 percent owner 10 percent owner
Common Stock 302,000 $13 $3,926,000 Sale
5AM VENTURES V, L.P. 10 percent owner 10 percent owner
Common Stock 302,000 $13 $3,926,000 Sale
5AM VENTURES V, L.P. 10 percent owner 10 percent owner
Common Stock 298,000 $14.75 $4,395,500