Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 100 $3.07 $307 Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 300 $3.07 $920 Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 100 $3.05 $305 Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 600 $3.03 $1,818 Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 10 $3.01 $30 Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 10 $2.98 $30 Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 280 $2.97 $832 Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 398,600 $2.9 $1,155,940 Purchase
SCHALL THOMAS J. director director
Class A Common Stock 2,900 $2.55 $7,386 Purchase
FEINBERG PETER director director
Class A Common Stock 25,000 $2.55 $63,725 Purchase
BRAKEWOOD HAROLD EUGENE officer: Chief Business Officer officer: Chief Business Officer
Class A Common Stock 3,900 $2.57 $10,015 Purchase
MORALES MALLORY officer: Chief Accounting Officer officer: Chief Accounting Officer
Class A Common Stock 393 $2.55 $1,001 Purchase
MORALES MALLORY officer: Chief Accounting Officer officer: Chief Accounting Officer
Class A Common Stock 1,107 $2.72 $3,009 Purchase
NEUFELD LEAH R officer: CHIEF PEOPLE OFFICER officer: CHIEF PEOPLE OFFICER
Class A Common Stock 3,818 $2.88 $10,992 Purchase
HALL BRETT MATTHEW officer: CHIEF SCIENTIFIC OFFICER officer: CHIEF SCIENTIFIC OFFICER
Class A Common Stock 7,000 $2.86 $20,020 Purchase
FEINBERG PETER director director
Class A Common Stock 25,000 $2.56 $64,000 Purchase
ZESKIND BENJAMIN J. director, 10 percent owner, officer: P.. director, 10 percent owner, off..
Class A Common Stock 20,000 $2.77 $55,320 Purchase
BERMAN ANN E director director
Class A Common Stock 57,965 $2.13 $123,465 Purchase
FEINBERG PETER director director
Class A Common Stock 4,976 $3.06 $15,202 Purchase
FEINBERG PETER director director
Class A Common Stock 45,024 $2.31 $103,870 Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 400,000 $2.14 $856,400 Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 345,266 $3.24 $1,116,936 Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 98,570 $4.25 $418,430 Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 54,215 $5.37 $291,351 Sale
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Class A Common Stock 11,040 $5.97 $65,887 Option
ZESKIND BENJAMIN J. director, 10 percent owner, officer: P.. director, 10 percent owner, off..
Stock Option 2,500 $3.01 $7,525 Option
ZESKIND BENJAMIN J. director, 10 percent owner, officer: P.. director, 10 percent owner, off..
Class A Common Stock 2,500 $3.01 $7,525 Purchase
HALL BRETT MATTHEW officer: CHIEF SCIENTIFIC OFFICER officer: CHIEF SCIENTIFIC OFFICER
Class A Common Stock 2,551 $3.92 $10,000 Purchase
BOOKMAN MICHAEL officer: GENERAL COUNSEL AND SECRETARY officer: GENERAL COUNSEL AND SE..
Class A Common Stock 1,000 $4.88 $4,880 Purchase
KEATING LAURIE director director
Class A Common Stock 7,000 $5 $35,000 Purchase
AMIN BIREN officer: CFO, TREASURER officer: CFO, TREASURER
Class A Common Stock 1,000 $4.42 $4,420 Option
ZESKIND BENJAMIN J. director, 10 percent owner, officer: P.. director, 10 percent owner, off..
Stock Option 2,000 $3.01 $6,020 Option
ZESKIND BENJAMIN J. director, 10 percent owner, officer: P.. director, 10 percent owner, off..
Class A Common Stock 2,000 $3.01 $6,020 Purchase
ZESKIND BENJAMIN J. director, 10 percent owner, officer: P.. director, 10 percent owner, off..
Class A Common Stock 3,000 $8.02 $24,060 Purchase
HALL BRETT MATTHEW officer: CHIEF SCIENTIFIC OFFICER officer: CHIEF SCIENTIFIC OFFICER
Class A Common Stock 1,050 $7.91 $8,306 Purchase
BARRETT SCOTT officer: CHIEF MEDICAL OFFICER officer: CHIEF MEDICAL OFFICER
Class A Common Stock 900 $7.49 $6,737 Purchase
FEINBERG PETER director director
Class A Common Stock 6,667 $6.75 $45,002 Purchase
BERMAN ANN E director director
Class A Common Stock 6,000 $6.4 $38,400 Option
ZESKIND BENJAMIN J. director, 10 percent owner, officer: P.. director, 10 percent owner, off..
Stock Option 2,000 $3.01 $6,020 Option
ZESKIND BENJAMIN J. director, 10 percent owner, officer: P.. director, 10 percent owner, off..
Class A Common Stock 2,000 $3.01 $6,020 Purchase
FEINBERG PETER director director
Class A Common Stock 4,750 $24.45 $116,114 Purchase
ZESKIND BENJAMIN J. director, 10 percent owner, officer: P.. director, 10 percent owner, off..
Class A Common Stock 2,083 $22.87 $47,632 Purchase
FEINBERG PETER director director
Class A Common Stock 349 $21.25 $7,416 Purchase
FEINBERG PETER director director
Class A Common Stock 5,750 $21.51 $123,700 Purchase
BARRETT SCOTT officer: Chief Medical Officer officer: Chief Medical Officer
Class A Common Stock 667 $15 $10,005 Purchase
BERMAN ANN E director director
Class A Common Stock 3,500 $15 $52,500 Purchase
BOOKMAN MICHAEL officer: General Counsel and Secretary officer: General Counsel and Se..
Class A Common Stock 1,402 $15 $21,030 Purchase
CARPENTER ROBERT J director director
Class A Common Stock 325,000 $15 $4,875,000 Purchase
HALL BRETT MATTHEW officer: Chief Scientific Officer officer: Chief Scientific Officer
Class A Common Stock 1,353 $15 $20,295 Purchase
KEATING LAURIE director director
Class A Common Stock 7,000 $15 $105,000 
