Sale
CAMPBELL DAVID ALAN director, officer: President and CEO director, officer: President an..
Common Stock 25,000 $56.19 $1,404,800 Option
MEYER ANDREW HOLLMAN officer: Chief Business Officer officer: Chief Business Officer
Stock Option (right to buy) 9,880 $20.24 $199,971 Option
MEYER ANDREW HOLLMAN officer: Chief Business Officer officer: Chief Business Officer
Stock Option (right to buy) 1 $14.02 $14 Option
MEYER ANDREW HOLLMAN officer: Chief Business Officer officer: Chief Business Officer
Common Stock 1 $14.02 $14 Option
MEYER ANDREW HOLLMAN officer: Chief Business Officer officer: Chief Business Officer
Common Stock 9,880 $20.24 $199,971 Sale
CAMPBELL DAVID ALAN director, officer: President and CEO director, officer: President an..
Common Stock 15,000 $67 $1,005,000 Sale
CAMPBELL DAVID ALAN director, officer: President and CEO director, officer: President an..
Common Stock 18,281 $51.43 $940,228 Sale
CAMPBELL DAVID ALAN director, officer: President and CEO director, officer: President an..
Common Stock 6,719 $52.04 $349,650 Sale
CAMPBELL DAVID ALAN director, officer: President and CEO director, officer: President an..
Common Stock 13,897 $53.22 $739,654 Sale
CAMPBELL DAVID ALAN director, officer: President and CEO director, officer: President an..
Common Stock 11,103 $53.94 $598,907 Purchase
RA CAPITAL MANAGEMENT, L.P. director, 10 percent owner: director, 10 percent owner:
Common Stock 1,200,000 $44.75 $53,700,000 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 104,892 $50.3 $5,276,068 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 15,788 $51.18 $808,030 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 102,732 $50.3 $5,167,420 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 15,462 $51.18 $791,345 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 553,219 $44.75 $24,756,550 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 541,824 $44.75 $24,246,624 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 19,900 $50.3 $1,000,970 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 2,995 $51.18 $153,284 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 104,957 $44.75 $4,696,826 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Stock Option (right to buy) 836 $17 $14,212 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Stock Option (right to buy) 696 $11.98 $8,335 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 237 $39.8 $9,433 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 348 $13.22 $4,601 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 348 $10.73 $3,734 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 836 $17 $14,212 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 1,843 $50.02 $92,187 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Stock Option (right to buy) 237 $39.8 $9,433 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 61,445 $49.69 $3,053,202 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 30,094 $50.61 $1,523,057 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 60,179 $49.69 $2,990,295 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 29,474 $50.61 $1,491,679 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 11,657 $49.69 $579,236 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 5,710 $50.61 $288,983 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Stock Option (right to buy) 4,968 $17 $84,456 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 1,407 $39.8 $55,999 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 2,070 $13.22 $27,365 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 2,070 $10.73 $22,211 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 4,968 $17 $84,456 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Stock Option (right to buy) 4,140 $11.98 $49,577 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 10,957 $50.8 $556,616 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Stock Option (right to buy) 1,407 $39.8 $55,999 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Stock Option (right to buy) 434 $17 $7,378 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Stock Option (right to buy) 362 $11.98 $4,335 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 123 $39.8 $4,895 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 181 $13.22 $2,393 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Stock Option (right to buy) 123 $39.8 $4,895 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 181 $10.73 $1,942 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 434 $17 $7,378 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 958 $46.24 $44,298