Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 46,861 $46.42 $2,175,288 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 1,542 $47.74 $73,615 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 45,894 $46.42 $2,130,399 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 1,511 $47.74 $72,135 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 8,894 $46.42 $412,859 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 293 $47.74 $13,988 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Stock Option (right to buy) 828 $17 $14,076 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Stock Option (right to buy) 690 $11.98 $8,263 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 234 $39.8 $9,313 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 345 $13.22 $4,561 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 345 $10.73 $3,702 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Stock Option (right to buy) 234 $39.8 $9,313 Option
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 828 $17 $14,076 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 1,826 $46.19 $84,343 Option
MEYER ANDREW HOLLMAN officer: Chief Business Officer officer: Chief Business Officer
Common Stock 50,000 $4.21 $210,500 Option
MEYER ANDREW HOLLMAN officer: Chief Business Officer officer: Chief Business Officer
Stock Option (right to buy) 50,000 $4.21 $210,500 Sale
MEYER ANDREW HOLLMAN officer: Chief Business Officer officer: Chief Business Officer
Common Stock 50,000 $45.96 $2,297,750 Sale
DIRAIMONDO THOMAS officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 4,325 $46.21 $199,841 Sale
DIRAIMONDO THOMAS officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 675 $47.23 $31,877 Sale
CAMPBELL DAVID ALAN director, officer: President and CEO director, officer: President an..
Common Stock 18,957 $46.09 $873,709 Sale
CAMPBELL DAVID ALAN director, officer: President and CEO director, officer: President an..
Common Stock 5,248 $46.86 $245,895 Sale
CAMPBELL DAVID ALAN director, officer: President and CEO director, officer: President an..
Common Stock 795 $47.84 $38,031 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 50,539 $46.78 $2,364,214 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 41,661 $47.77 $1,990,146 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 49,497 $46.78 $2,315,470 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 40,803 $47.77 $1,949,159 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 9,592 $46.78 $448,714 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 7,908 $47.77 $377,765 Option
LICHTER JAY 10 percent owner 10 percent owner
Stock Option (right to buy) 1,868 $17 $31,756 Option
LICHTER JAY 10 percent owner 10 percent owner
Stock Option (right to buy) 1,556 $11.98 $18,633 Option
LICHTER JAY 10 percent owner 10 percent owner
Common Stock 391 $39.8 $15,562 Option
LICHTER JAY 10 percent owner 10 percent owner
Common Stock 778 $13.22 $10,285 Option
LICHTER JAY 10 percent owner 10 percent owner
Common Stock 778 $10.73 $8,348 Option
LICHTER JAY 10 percent owner 10 percent owner
Common Stock 1,868 $17 $31,756 Option
LICHTER JAY 10 percent owner 10 percent owner
Stock Option (right to buy) 391 $39.8 $15,562 Sale
LICHTER JAY 10 percent owner 10 percent owner
Common Stock 3,815 $46.68 $178,084 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 161,356 $47 $7,583,732 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 158,031 $47 $7,427,457 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 30,613 $47 $1,438,811 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 11,557 $46.13 $533,124 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 35,047 $46.66 $1,635,293 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 11,319 $46.13 $522,145 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 34,326 $46.66 $1,601,651 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 2,193 $46.13 $101,163 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 6,649 $46.66 $310,242 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 110,644 $42 $4,647,048 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 108,365 $42 $4,551,330 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 20,991 $42 $881,622 Sale
REARDON TIGHE officer: Acting Chief Financial Officer officer: Acting Chief Financial..
Common Stock 131,196 $54.75 $7,182,981 Sale
AVALON VENTURES XI, L.P. 10 percent owner 10 percent owner
Common Stock 691,525 $54.75 $37,860,994