Option
YEA CHRISTOPHER officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 600 $17.01 $10,205 Option
YEA CHRISTOPHER officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 1,302 $0 $5 Option
YEA CHRISTOPHER officer: Chief Development Officer officer: Chief Development Offi..
Employee Stock Option (Right to Buy) 1,302 $0 $5 Sale
YEA CHRISTOPHER officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 1,302 $0 $5 Sale
FEENER EDWARD P. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 4,000 $19.51 $78,024 Sale
CROCKETT THOMAS ANDREW director, officer: CEO director, officer: CEO
Common Stock 10,000 $19.57 $195,710 Sale
SVLSF IV, LLC 10 percent owner 10 percent owner
Common Stock 2,599 $20.41 $53,051 Sale
SVLSF IV, LLC 10 percent owner 10 percent owner
Common Stock 1,700 $20.01 $34,022 Sale
SVLSF IV, LLC 10 percent owner 10 percent owner
Common Stock 200 $20 $4,000 Sale
SVLSF IV, LLC 10 percent owner 10 percent owner
Common Stock 25,418 $20 $508,462 Sale
SVLSF IV, LLC 10 percent owner 10 percent owner
Common Stock 3,734 $20.03 $74,781 Sale
SVLSF IV, LLC 10 percent owner 10 percent owner
Common Stock 2,136 $20.02 $42,758 Purchase
ORONSKY ARNOLD L director director
Common Stock 58,824 $17 $1,000,008 Purchase
CHA ALBERT director director
Common Stock 1,058,824 N/A N/A Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 1,726,481 $9.26 $15,987,214 Purchase
SHAH RAJEEV M. director, 10 percent owner director, 10 percent owner
Common Stock 850,000 $8.5 $7,225,000 Purchase
RA CAPITAL MANAGEMENT, LLC director, 10 percent owner director, 10 percent owner
Common Stock 850,000 $8.5 $7,225,000 Purchase
ALDRICH RICHARD director director
Common Stock 565,065 N/A N/A Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 35,519 $10.21 $362,756 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 963,283 $12.78 $12,309,793 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 140,747 $7.5 $1,055,884 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 10,000 $8.05 $80,500 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 25,900 $8.02 $207,614 Option
RENZI DAVID director, officer: President & CEO director, officer: President & ..
Stock Option (Right to Buy) 36,640 $7.84 $287,258 Option
RENZI DAVID director, officer: President & CEO director, officer: President & ..
Common Stock 36,640 $7.84 $287,258 Option
MARONEY MARCEE officer: VP, Clinical Affairs officer: VP, Clinical Affairs
Stock Option (Right to Buy) 2,592 $7.84 $20,321 Option
MARONEY MARCEE officer: VP, Clinical Affairs officer: VP, Clinical Affairs
Common Stock 4,664 $7.84 $36,566 Option
BASTA STEVEN L director director
Common Stock 1,125 $7.84 $8,820 Option
BASTA STEVEN L director director
Stock Option (Right to Buy) 1,125 $7.84 $8,820 Option
RENZI DAVID director, officer: President & CEO director, officer: President & ..
Stock Option (Right to Buy) 10,000 $0.56 $5,600 Option
RENZI DAVID director, officer: President & CEO director, officer: President & ..
Common Stock 10,000 $0.56 $5,600 Sale
RENZI DAVID director, officer: President & CEO director, officer: President & ..
Common Stock 10,000 $0.56 $5,600 Purchase
ACMP IV LLC 10 percent owner 10 percent owner
Common Stock 877,500 $5 $4,387,500 Purchase
VIVO VENTURES VI, LLC 10 percent owner 10 percent owner
Common Stock 2,025,000 $5 $10,125,000 Purchase
CHA ALBERT
Common Stock 2,025,000 $5 $10,125,000 Purchase
CHA ALBERT
Common Stock 2,025,000 $5 $10,125,000 Purchase
INTERWEST MANAGEMENT PARTNERS IX, LLC 10 percent owner 10 percent owner
Common Stock 810,000 $5 $4,050,000 Purchase
CHA ALBERT
Common Stock 2,025,000 $5 $10,125,000 Purchase
NOHRA GUY P director director
Common Stock 877,500 $5 $4,387,500 Purchase
VIVO VENTURES VI, LLC 10 percent owner 10 percent owner
Common Stock 2,025,000 $5 $10,125,000