| Utility: FORMULATIONS OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6- -DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CAR- BONITRILE Filling date: 26 Sep 2025 Issue date: 30 Jun 2022 | 21 Jan 2022 | 30 Jun 2022 |
| Utility: METHODS OF DIAGNOSING AND TREATING CANCER Filling date: 26 Sep 2025 Issue date: 24 Mar 2022 | 23 Nov 2021 | 24 Mar 2022 |
| Utility: FORMULATIONS OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6- -DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CAR- BONITRILE Filling date: 26 Sep 2025 Issue date: 24 Mar 2022 | 18 Nov 2021 | 24 Mar 2022 |
| Utility: COMPOUNDS USEFUL AS KINASE INHIBITORS Filling date: 26 Sep 2025 Issue date: 3 Mar 2022 | 12 Nov 2021 | 3 Mar 2022 |
| Utility: Process for the preparation of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrim- idin-3-yl)-3-hydroxypyrrolidine-1-carboxamide and salts thereof Filling date: 26 Sep 2025 Issue date: 4 Jan 2022 | 18 May 2017 | 4 Jan 2022 |
| Utility: PROCESS FOR THE PREPARATION OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6- -DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CAR- BONITRILE Filling date: 26 Sep 2025 Issue date: 9 Dec 2021 | 13 Aug 2021 | 9 Dec 2021 |
| Utility: Methods of treating pediatric cancers Filling date: 26 Sep 2025 Issue date: 7 Dec 2021 | 10 Jan 2020 | 7 Dec 2021 |
| Utility: SPRAY-DRIED DISPERSIONS, FORMULATIONS, AND POLYMORPHS OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)-1-(1,1,1-TR- IFLUOROPROPAN-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE Filling date: 26 Sep 2025 Issue date: 28 Oct 2021 | 29 Jul 2019 | 28 Oct 2021 |
| Utility: Process for the preparation of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6- -diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-car- bontrile Filling date: 26 Sep 2025 Issue date: 24 Aug 2021 | 16 Jun 2020 | 24 Aug 2021 |
| Utility: Process for the preparation of pyrazolo[1,5-a]pyrimidines and salts thereof Filling date: 26 Sep 2025 Issue date: 17 Aug 2021 | 26 Oct 2017 | 17 Aug 2021 |
| Utility: POINT MUTATIONS IN TRK INHIBITOR-RESISTANT CANCER AND METHODS RELATING TO THE SAME Filling date: 26 Sep 2025 Issue date: 3 Jun 2021 | 1 Feb 2021 | 3 Jun 2021 |
| Utility: COMPOUNDS USEFUL AS KINASE INHIBITORS Filling date: 26 Sep 2025 Issue date: 1 Apr 2021 | 15 Dec 2020 | 1 Apr 2021 |
| Utility: FORMULATIONS OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6- -DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CAR- BONITRILE Filling date: 26 Sep 2025 Issue date: 18 Mar 2021 | 25 Aug 2020 | 18 Mar 2021 |
| Utility: Compounds useful as kinase inhibitors Filling date: 26 Sep 2025 Issue date: 16 Feb 2021 | 13 May 2020 | 16 Feb 2021 |
| Utility: Point mutations in TRK inhibitor-resistant cancer and methods relating to the same Filling date: 26 Sep 2025 Issue date: 2 Feb 2021 | 3 Jan 2018 | 2 Feb 2021 |
| Utility: TREATMENT OF TRK-ASSOCIATED CANCERS Filling date: 26 Sep 2025 Issue date: 28 Jan 2021 | 29 Mar 2019 | 28 Jan 2021 |
| Utility: LIQUID FORMULATIONS OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)-PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRI- MIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE Filling date: 26 Sep 2025 Issue date: 29 Oct 2020 | 27 Apr 2020 | 29 Oct 2020 |
| Utility: PROCESS FOR THE PREPARATION OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6- -DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CAR- BONITRILE Filling date: 26 Sep 2025 Issue date: 1 Oct 2020 | 16 Jun 2020 | 1 Oct 2020 |
| Utility: Formulations of 6-(2-hydroxy-2-methylpropxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-- diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-A]pyridine-3-carb- onitrile Filling date: 26 Sep 2025 Issue date: 29 Sep 2020 | 10 Oct 2018 | 29 Sep 2020 |
| Utility: COMPOUNDS USEFUL AS KINASE INHIBITORS Filling date: 26 Sep 2025 Issue date: 3 Sep 2020 | 13 May 2020 | 3 Sep 2020 |
| Utility: Process for the preparation of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6- -diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-car- bonitrile Filling date: 26 Sep 2025 Issue date: 18 Aug 2020 | 10 Oct 2018 | 18 Aug 2020 |
| Utility: METHODS OF TREATING PEDIATRIC CANCERS Filling date: 26 Sep 2025 Issue date: 30 Jul 2020 | 10 Jan 2020 | 30 Jul 2020 |
| Utility: Point mutations in TRK inhibitor-resistant cancer and methods relating to the same Filling date: 26 Sep 2025 Issue date: 28 Jul 2020 | 26 Oct 2016 | 28 Jul 2020 |
| Utility: PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF Filling date: 26 Sep 2025 Issue date: 9 Jul 2020 | 26 Oct 2017 | 9 Jul 2020 |
| Utility: Compounds useful as kinase inhibitors Filling date: 26 Sep 2025 Issue date: 30 Jun 2020 | 16 Dec 2016 | 30 Jun 2020 |
| Utility: Liquid formulations of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyri- midin-3-yl)-3-hydroxypyrrolidine-1-carboxamide Filling date: 26 Sep 2025 Issue date: 2 Jun 2020 | 26 Nov 2018 | 2 Jun 2020 |
| Utility: Point mutations in TRK inhibitor-resistant cancer and methods relating to the same Filling date: 26 Sep 2025 Issue date: 19 May 2020 | 16 Oct 2017 | 19 May 2020 |
| Utility: Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer Filling date: 26 Sep 2025 Issue date: 7 Apr 2020 | 16 Sep 2016 | 7 Apr 2020 |
| Utility: Methods of treating pediatric cancers Filling date: 26 Sep 2025 Issue date: 17 Mar 2020 | 3 Jan 2018 | 17 Mar 2020 |
| Utility: Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase Filling date: 26 Sep 2025 Issue date: 21 Jan 2020 | 11 May 2018 | 21 Jan 2020 |
| Utility: Compounds useful as kinase inhibitors Filling date: 26 Sep 2025 Issue date: 5 Nov 2019 | 27 Aug 2018 | 5 Nov 2019 |
| Utility: Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer Filling date: 26 Sep 2025 Issue date: 3 Sep 2019 | 27 Aug 2018 | 3 Sep 2019 |
| Utility: Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer Filling date: 26 Sep 2025 Issue date: 3 Sep 2019 | 22 Aug 2018 | 3 Sep 2019 |
| Utility: FORMULATIONS OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6- -DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CAR- BONITRILE Filling date: 26 Sep 2025 Issue date: 29 Aug 2019 | 10 Oct 2018 | 29 Aug 2019 |
| Utility: FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR Filling date: 26 Sep 2025 Issue date: 15 Aug 2019 | 25 Oct 2018 | 15 Aug 2019 |
| Utility: Point mutations in TRK inhibitor-resistant cancer and methods relating to the same Filling date: 26 Sep 2025 Issue date: 13 Aug 2019 | 16 Oct 2017 | 13 Aug 2019 |
| Utility: Point mutations in TRK inhibitor-resistant cancer and methods relating to the same Filling date: 26 Sep 2025 Issue date: 6 Aug 2019 | 16 Oct 2017 | 6 Aug 2019 |
