Sale
DALY JAMES M director director
Common Stock 7,401 $256.5 $1,898,371 Sale
DALY JAMES M director director
Common Stock 3,604 $257.3 $927,302 Sale
DALY JAMES M director director
Common Stock 1,460 $258.28 $377,093 Sale
DALY JAMES M director director
Common Stock 200 $259.11 $51,822 Sale
DALY JAMES M director director
Common Stock 800 $262.01 $209,604 Sale
DALY JAMES M director director
Common Stock 178 $263.31 $46,870 Sale
DALY JAMES M director director
Common Stock 351 $264.89 $92,977 Sale
DALY JAMES M director director
Common Stock 500 $265.49 $132,743 Sale
DALY JAMES M director director
Common Stock 274 $266.91 $73,132 Option
DALY JAMES M director director
Stock Option (Right to Buy) 20,000 $100.45 $2,009,000 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock Warrant (right to buy) 970,951 N/A N/A Purchase
BAKER BROS. ADVISORS LP director director
Common Stock Warrant (right to buy) 86,741 N/A N/A Option
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Stock Option (Right to Buy) 2,000 $87.92 $175,840 Option
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Common Stock 2,000 $87.92 $175,840 Sale
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Common Stock 1,000 $236 $236,000 Sale
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Common Stock 1,000 $241 $241,000 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 3,960 $229.87 $910,265 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 2,204 $228.79 $504,251 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 1,343 $226.97 $304,822 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 316 $229.87 $72,637 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 176 $228.79 $40,267 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 11,602 $227.86 $2,643,597 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 925 $227.86 $210,768 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 107 $226.97 $24,286 Option
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Stock Option (Right to Buy) 2,000 $87.92 $175,840 Sale
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Common Stock 1,000 $233 $233,000 Sale
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Common Stock 1,000 $232 $232,000 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 5,594 $224.91 $1,258,158 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 363 $223.94 $81,289 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 9,262 $222.68 $2,062,425 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 4,532 $221.78 $1,005,102 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 4,518 $219.87 $993,350 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 29,738 $218.46 $6,496,504 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 10,894 $217.52 $2,369,608 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 10,264 $216.7 $2,224,199 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 446 $224.91 $100,311 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 29 $223.94 $6,494 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 738 $222.68 $164,335 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 361 $221.78 $80,062 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 360 $219.87 $79,151 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 2,373 $218.46 $518,401 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 869 $217.52 $189,021 Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 818 $216.7 $177,260 Option
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Stock Option (Right to Buy) 2,500 $87.92 $219,800 Option
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Common Stock 2,500 $87.92 $219,800 Sale
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Common Stock 1,500 $225 $337,500 Sale
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Common Stock 1,000 $226 $226,000 Option
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Stock Option (Right to Buy) 1,300 $87.92 $114,296 Option
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Common Stock 1,300 $87.92 $114,296 Sale
WALTERMIRE ROBERT E. officer: Senior VP, Chief Pharma Dev. officer: Senior VP, Chief Pharm..
Common Stock 500 $216 $108,000