Purchase
BHARUCHA DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Shares 7,000 $4.69 $32,830 Purchase
BHARUCHA DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Shares 3,000 $4.86 $14,580 Purchase
LIEBERT DEBRA K. director director
Common Shares 4,000 $5.26 $21,040 Purchase
PASTERNAK RICHARD C director director
Common Shares 10,000 $5.2 $52,000 Purchase
LIEBERT DEBRA K. director director
Common Shares 10,000 $5.29 $52,900 Purchase
WILLS ROBERT JAMES director director
Common Shares 15,000 $4.93 $73,950 Purchase
TOMSICEK MICHAEL JOHN director director
Common Shares 15,000 $5.32 $79,800 Sale
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 1,557,346 $8.71 $13,564,484 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares, no par value ("Common Shares") 1,557,346 $8.71 $13,564,484 Option
TRUEX PAUL F director director
Stock Option (right to buy) 822 $2.66 $2,187 Option
TRUEX PAUL F director director
Stock Option (right to buy) 22,870 $1.54 $35,220 Option
TRUEX PAUL F director director
Stock Option (right to buy) 45,072 $1.54 $69,411 Purchase
TRUEX PAUL F director director
Common Shares 5,000 $5.6 $28,000 Option
TRUEX PAUL F director director
Common Shares 822 $2.66 $2,187 Option
TRUEX PAUL F director director
Common Shares 22,870 $1.54 $35,220 Option
TRUEX PAUL F director director
Common Shares 45,072 $1.54 $69,411 Option
TRUEX PAUL F director director
Common Shares 8,016 $1.12 $8,978 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Pre-Funded Warrant 910,746 $0.01 $9,107 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Pre-Funded Warrant 952,380 $0.01 $9,524 Option
MULLER LORENZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Employee Stock Option (right to buy) 5,700 $1.54 $8,778 Option
MULLER LORENZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 5,700 $1.54 $8,778 Sale
FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC 10 percent .. 10 percent owner
Common shares 500,000 $8.32 $4,160,000 Sale
FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC 10 percent .. 10 percent owner
Common shares 19,863 $8.1 $160,890 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Pre-Funded Warrant 6,655,131 $0.01 $66,551 Option
MULLER LORENZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Shares 50,571 N/A N/A Option
MULLER LORENZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Employee Stock Option (right to buy) 50,571 N/A N/A Option
MULLER LORENZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Employee Stock Option (right to buy) 50,571 $1.54 $77,879 Option
MULLER LORENZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Shares 50,571 $1.54 $77,879 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 5,870 $10.87 $63,807 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 2,705 $10.36 $28,029 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 78,263 $18.95 $1,483,084 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 270,000 $16.25 $4,387,500 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 21,438 $15.5 $332,332 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 1,333 $15.48 $20,638 Option
OLIVETO JOSEPH director, officer: President and CEO director, officer: President an..
Employee Stock Option (right to buy) 7,400 $1.54 $11,396 Option
OLIVETO JOSEPH director, officer: President and CEO director, officer: President an..
Common Shares 7,400 $1.54 $11,396 Sale
NOVO HOLDINGS A/S 10 percent owner, other: SEE REMARKS 10 percent owner, other: SEE RE..
COMMON SHARES 240,000 $16 $3,840,000 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 400,000 $16 $6,400,000 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 1,100 $18 $19,800 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 4,208 $17.3 $72,790 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 179 $16 $2,864 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 1,908 $18.31 $34,939 Option
MULLER LORENZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Shares 2,500 $1.54 $3,850 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 6,242 $17.63 $110,040 Option
MULLER LORENZ officer: Chief Commercial Officer officer: Chief Commercial Officer
Employee Stock Option (right to buy) 2,500 $1.54 $3,850 Option
NOVO HOLDINGS A/S 10 percent owner, other: SEE REMARKS 10 percent owner, other: SEE RE..
COMMON SHARES 2,341,137 N/A N/A Purchase
NOVO HOLDINGS A/S 10 percent owner, other: SEE REMARKS 10 percent owner, other: SEE RE..
COMMON SHARES 333,333 $15 $4,999,995 Option
NOVO HOLDINGS A/S 10 percent owner, other: SEE REMARKS 10 percent owner, other: SEE RE..
CLASS C PREFERRED SHARES 1,377,048 N/A N/A Purchase
FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC 10 percent .. 10 percent owner
Common Shares 433,333 $15 $6,499,995 Purchase
RTW INVESTMENTS, LP 10 percent owner 10 percent owner
Common Shares 666,667 $15 $10,000,005