Option
LINDE PETER officer: Chief Medical Officer officer: Chief Medical Officer
Restricted Stock Unit (RSU 10,378 N/A N/A Sale
LINDE PETER officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,900 $66.74 $260,286 Option
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,721 $65.01 $111,874 Option
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,721 $4.32 $7,435 Sale
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,721 $65.01 $111,874 Sale
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,721 $4.32 $7,435 Option
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy Common Stock) 1,721 $4.32 $7,435 Option
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Common Stock 3,049 $65.01 $198,203 Sale
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Common Stock 3,049 $65.01 $198,203 Option
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 8,279 $65.11 $539,079 Option
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 8,279 $4.32 $35,765 Sale
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 8,279 $65.11 $539,079 Sale
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 8,279 $4.32 $35,765 Option
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy Common Stock) 8,279 $4.32 $35,765 Option
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy Common Stock) 30,000 $4.32 $129,600 Option
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 30,000 $60.82 $1,824,630 Sale
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy Common Stock) 1,701 $4.32 $7,348 Sale
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 28,299 $61.24 $1,732,946 Sale
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 30,000 $4.32 $129,600 Option
ROGERS BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy Common Stock) 30,000 $4.32 $129,600 Purchase
SPRINGER TIMOTHY A director, 10 percent owner director, 10 percent owner
Common Stock 11,620 $56.41 $655,426 Purchase
SPRINGER TIMOTHY A director, 10 percent owner director, 10 percent owner
Common Stock 33,000 $55.95 $1,846,218 Purchase
SPRINGER TIMOTHY A director, 10 percent owner director, 10 percent owner
Common Stock 30,307 $55.89 $1,693,707 Option
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Common Stock 200 $65 $13,000 Sale
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Common Stock 200 $65 $13,000 Option
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Stock Option (right to buy Common Stock) 200 $65 $13,000 Option
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Common Stock 300 $4.32 $1,296 Sale
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Common Stock 300 $4.32 $1,296 Option
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Stock Option (right to buy Common Stock) 300 $4.32 $1,296 Option
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Common Stock 3,526 $65 $229,201 Sale
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Common Stock 3,526 $65 $229,201 Option
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Stock Option (right to buy Common Stock) 3,526 $65 $229,201 Option
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Common Stock 16,000 $4.32 $69,120 Sale
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Common Stock 16,000 $4.32 $69,120 Option
FARRELL ROBERT E JR officer: SVP Finance and CAO officer: SVP Finance and CAO
Stock Option (right to buy Common Stock) 16,000 $4.32 $69,120 Sale
LINDE PETER officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 6,000 $50.01 $300,072 Purchase
SPRINGER TIMOTHY A director, 10 percent owner director, 10 percent owner
Common Stock 25,000 N/A N/A Purchase
SPRINGER TIMOTHY A director, 10 percent owner director, 10 percent owner
Common Stock 65,000 N/A N/A Purchase
SPRINGER TIMOTHY A director, 10 percent owner director, 10 percent owner
Common Stock 40,000 N/A N/A Sale
NASHAT AMIR director director
Common Stock 232,295 $45.5 $10,569,423 Purchase
SPRINGER TIMOTHY A director, 10 percent owner director, 10 percent owner
Common Stock 232,295 N/A N/A Sale
OMEGA FUND V, L.P. director director
Common Stock 9,487 $55.01 $521,880 Sale
OMEGA FUND V, L.P. director director
Common Stock 9,487 N/A N/A Sale
OMEGA FUND V, L.P. director director
Common Stock 7,671 $54.37 $417,072 Sale
OMEGA FUND V, L.P. director director
Common Stock 3,366 N/A N/A Sale
OMEGA FUND V, L.P. director director
Common Stock 7,338 N/A N/A Sale
OMEGA FUND V, L.P. director director
Common Stock 5,146 $56.51 $290,800 Sale
OMEGA FUND V, L.P. director director
Common Stock 5,146 $56.51 $290,800 Sale
OMEGA FUND V, L.P. director director
Common Stock 8,672 N/A N/A Sale
OMEGA FUND V, L.P. director director
Common Stock 8,672 $56.2 $487,366