Sale
EDRIS BADREDDIN officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 11,966 $41.78 $499,939 Sale
EDRIS BADREDDIN officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 8,034 $42.25 $339,396 Sale
ISLAM SAQIB director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 45,011 $41.33 $1,860,440 Sale
ISLAM SAQIB director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 3,989 $41.85 $166,936 Sale
ISLAM SAQIB director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 32,400 $40.1 $1,299,240 Sale
ISLAM SAQIB director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 9,908 $41.1 $407,258 Sale
ISLAM SAQIB director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 6,692 $42.07 $281,553 Sale
EDRIS BADREDDIN officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 12,300 $40.12 $493,415 Sale
EDRIS BADREDDIN officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 4,620 $41.12 $189,956 Sale
EDRIS BADREDDIN officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 3,080 $42.08 $129,591 Sale
ISLAM SAQIB director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 33,240 $39.4 $1,309,656 Sale
ISLAM SAQIB director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 8,760 $40.57 $355,367 Sale
ISLAM SAQIB director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 6,600 $41.4 $273,247 Sale
ISLAM SAQIB director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 400 $42.09 $16,837 Sale
HAMBLETON JULIE director director
Common Stock 2,946 $39.41 $116,111 Sale
HAMBLETON JULIE director director
Common Stock 751 $40.57 $30,466 Sale
HAMBLETON JULIE director director
Common Stock 931 $41.49 $38,629 Sale
HAMBLETON JULIE director director
Common Stock 20 $42.09 $842 Sale
EDRIS BADREDDIN officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 11,772 $39.4 $463,840 Sale
EDRIS BADREDDIN officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 4,192 $40.62 $170,287 Sale
EDRIS BADREDDIN officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 3,651 $41.38 $151,067 Sale
EDRIS BADREDDIN officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 385 $42.04 $16,184 Option
PICHL DANIEL officer: Chief People Officer officer: Chief People Officer
Common Stock 15,000 $27.64 $414,600 Sale
PICHL DANIEL officer: Chief People Officer officer: Chief People Officer
Common Stock 15,000 $50.1 $751,545 Option
PICHL DANIEL officer: Chief People Officer officer: Chief People Officer
Stock Option (Right to Buy) 15,000 $27.64 $414,600 Sale
ASHAR BHAVESH officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 4,834 $49.33 $238,437 Sale
ASHAR BHAVESH officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 1,089 $43.75 $47,640 Sale
ASHAR BHAVESH officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 1,667 $44.31 $73,868 Sale
ASHAR BHAVESH officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 378 $46 $17,387 Sale
ASHAR BHAVESH officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 88 $46.37 $4,081 Option
PICHL DANIEL officer: Chief People Officer officer: Chief People Officer
Common Stock 16,250 $27.64 $449,150 Sale
PICHL DANIEL officer: Chief People Officer officer: Chief People Officer
Common Stock 9,266 $43.81 $405,943 Option
PICHL DANIEL officer: Chief People Officer officer: Chief People Officer
Stock Option (Right to Buy) 16,250 $27.64 $449,150 Sale
PICHL DANIEL officer: Chief People Officer officer: Chief People Officer
Common Stock 14,175 $44.31 $628,151 Sale
PICHL DANIEL officer: Chief People Officer officer: Chief People Officer
Common Stock 1,997 $45.95 $91,756 Sale
PICHL DANIEL officer: Chief People Officer officer: Chief People Officer
Common Stock 743 $46.44 $34,507 Sale
HAMBLETON JULIE director director
Common Stock 2,418 $29.31 $70,876 Sale
HAMBLETON JULIE director director
Common Stock 2,400 $26.92 $64,603 Sale
SCHWARTZ JEFFREY LAWRENCE director director
Common Stock 1,750,000 $28.5 $49,875,000 Sale
HAMBLETON JULIE director director
Common Stock 1,106 $31.5 $34,841 Sale
PICHL DANIEL officer: Chief People Officer officer: Chief People Officer
Common Stock 858 $31 $26,598 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 30,000 $31.98 $959,400 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 123,897 $31.96 $3,959,748 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 69,568 $37.47 $2,606,713 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 205,000 $38.33 $7,857,650 Sale
ISLAM SAQIB director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 10,083 $58.67 $591,529 Sale
ISLAM SAQIB director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 14,077 $58.81 $827,868 Sale
ISLAM SAQIB director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 38,340 $58.59 $2,246,494 Option
SMITH L. MARY officer: Chief Development Officer officer: Chief Development Offi..
Stock Option (Right to Buy) 10,000 $2.3 $23,000 Sale
SMITH L. MARY officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 10,000 $55.97 $559,680 
