Purchase
RA CAPITAL MANAGEMENT, L.P. director, 10 percent owner: director, 10 percent owner:
Common Stock 3,000,000 $10 $30,000,000 Purchase
RA CAPITAL MANAGEMENT, L.P. director, 10 percent owner: director, 10 percent owner:
Pre- Funded Warrants (Right to Buy) 3,000,031 N/A N/A Purchase
GEORGE SIMEON director director
Common Stock 1,548,341 $10 $15,483,410 Purchase
GEORGE SIMEON director director
Common Stock 451,659 $10 $4,516,590 Option
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 2,955 $3.89 $11,495 Option
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 3,808 $3.89 $14,813 Sale
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 8,367 $12.51 $104,671 Option
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Stock Option (right to buy) 2,955 $3.89 $11,495 Option
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Stock Option (right to buy) 3,808 $3.89 $14,813 Sale
TRAGER JAMES officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 4,143 $12 $49,716 Sale
SHOOK DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,552 $8.74 $31,044 Sale
TRAGER JAMES officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 4,560 $8.74 $39,854 Sale
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 2,512 $8.74 $21,955 Sale
HASTINGS PAUL J director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 9,697 $8.74 $84,752 Sale
HAGER ALICIA J. officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 4,554 $8.74 $39,802 Sale
SHOOK DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,331 $1.83 $2,436 Sale
TRAGER JAMES officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 439 $4.85 $2,129 Sale
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 221 $4.85 $1,072 Sale
HAGER ALICIA J. officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 701 $4.85 $3,400 Sale
SHOOK DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 439 $4.85 $2,129 Sale
MAHMOOD NADIR officer: See Remarks officer: See Remarks
Common Stock 526 $4.85 $2,551 Sale
HASTINGS PAUL J director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 1,704 $4.85 $8,264 Sale
HAGER ALICIA J. officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 1,103 $5.49 $6,055 Sale
HASTINGS PAUL J officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 3,691 $5.49 $20,264 Sale
MAHMOOD NADIR officer: See Remarks officer: See Remarks
Common Stock 1,122 $5.49 $6,160 Sale
SHOOK DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 175 $5.49 $961 Sale
TRAGER JAMES officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,115 $5.49 $6,121 Sale
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 491 $5.49 $2,696 Option
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Stock Option (right to buy) 842 $3.89 $3,275 Sale
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 842 $14.02 $11,805 Option
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 842 $3.89 $3,275 Sale
HASTINGS PAUL J director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 498 $13 $6,474 Sale
HASTINGS PAUL J director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 23,376 $13.03 $304,613 Sale
HASTINGS PAUL J director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 6,126 $13.01 $79,718 Option
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Stock Option (right to buy) 11,000 $3.89 $42,790 Sale
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 11,000 $17.64 $194,051 Option
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 11,000 $3.89 $42,790 Option
TRAGER JAMES officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 5,000 $3.89 $19,450 Sale
TRAGER JAMES officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 5,000 $17.53 $87,655 Option
TRAGER JAMES officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 5,000 $3.89 $19,450 Option
MAHMOOD NADIR officer: Chief Financial and Business Officer officer: Chief Financial and Bu..
Stock Option (right to buy) 2,681 $3.89 $10,429 Option
MAHMOOD NADIR officer: Chief Financial and Business Officer officer: Chief Financial and Bu..
Stock Option (right to buy) 4,819 $3.89 $18,746 Sale
MAHMOOD NADIR officer: Chief Financial and Business Officer officer: Chief Financial and Bu..
Common Stock 7,500 $18.03 $135,218 Option
MAHMOOD NADIR officer: Chief Financial and Business Officer officer: Chief Financial and Bu..
Common Stock 7,500 $3.89 $29,175 Option
MAHMOOD NADIR officer: Chief Financial and Business Officer officer: Chief Financial and Bu..
Stock Option (right to buy) 7,500 $3.89 $29,175 Sale
MAHMOOD NADIR officer: Chief Financial and Business Officer officer: Chief Financial and Bu..
Common Stock 7,500 $15.32 $114,900 Option
MAHMOOD NADIR officer: Chief Financial and Business Officer officer: Chief Financial and Bu..
Common Stock 7,500 $3.89 $29,175 Option
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Stock Option (right to buy) 340 $4.77 $1,622 Option
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Stock Option (right to buy) 4,367 $0.41 $1,790 Sale
BRANDENBERGER RALPH officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 11,593 $15.51 $179,784