Purchase
LYNX1 CAPITAL MANAGEMENT LP 10 percent owner 10 percent owner
Common Stock 100,000 $2.9 $290,100 Purchase
LYNX1 CAPITAL MANAGEMENT LP 10 percent owner 10 percent owner
Common stock, $0.0001 par value per share ("Common Stock") 31,800 $3.01 $95,623 Purchase
LYNX1 CAPITAL MANAGEMENT LP 10 percent owner 10 percent owner
Common stock, $0.0001 par value per share 947 $4.34 $4,114 Purchase
KLENCKE BARBARA director director
Voting Common Stock 5,000 $5.29 $26,450 Purchase
KLENCKE BARBARA director director
Voting Common Stock 5,000 $5.53 $27,650 Purchase
KLENCKE BARBARA director director
Voting Common Stock 5,000 $5.69 $28,450 Option
ZDRAVESKI ZORAN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 64,166 $2.49 $159,773 Option
ZDRAVESKI ZORAN officer: See Remarks officer: See Remarks
Voting Common Stock 64,166 $2.49 $159,773 Option
ZDRAVESKI ZORAN officer: See Remarks officer: See Remarks
Voting Common Stock 13,125 $1.81 $23,756 Option
ZDRAVESKI ZORAN officer: See Remarks officer: See Remarks
Voting Common Stock 25,000 $3.27 $81,750 Option
ZDRAVESKI ZORAN officer: See Remarks officer: See Remarks
Voting Common Stock 54,895 $4.85 $266,241 Option
ZDRAVESKI ZORAN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 54,895 $4.85 $266,241 Option
ZDRAVESKI ZORAN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 25,000 $3.27 $81,750 Option
ZDRAVESKI ZORAN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 13,125 $1.81 $23,756 Sale
ZDRAVESKI ZORAN officer: See Remarks officer: See Remarks
Voting Common Stock 164,686 $5.78 $952,050 Purchase
BAKER BROS. ADVISORS LP director director
Warrants to purchase Common Stock 8,851,451 N/A N/A Purchase
BAKER BROS. ADVISORS LP director director
Warrants to purchase Common Stock 825,968 N/A N/A Purchase
LYNX1 CAPITAL MANAGEMENT LP 10 percent owner 10 percent owner
Pre-funded Warrant (right to buy) 5,000,000 N/A N/A Purchase
BARBERICH TIMOTHY J director director
Voting Common Stock 317 $4.97 $1,575 Purchase
BARBERICH TIMOTHY J director director
Voting Common Stock 28,830 $4.89 $140,892 Purchase
KLENCKE BARBARA director director
Voting Common Stock 5,000 $5.08 $25,400 Purchase
BARBERICH TIMOTHY J director director
Voting Common Stock 37,880 $2.63 $99,549 Sale
LYNX1 CAPITAL MANAGEMENT LP 10 percent owner 10 percent owner
Common stock, $0.0001 par value per share Common Stock 10,000 $2.52 $25,150 Sale
LYNX1 CAPITAL MANAGEMENT LP 10 percent owner 10 percent owner
Common Stock 15,000 $2.52 $37,800 Sale
LYNX1 CAPITAL MANAGEMENT LP 10 percent owner 10 percent owner
Common Stock 400 $2.51 $1,003 Purchase
SILVER BRIAN M. officer: Chief Financial Officer officer: Chief Financial Officer
Voting Common Stock 3,158 $1.57 $4,942 Purchase
SILVER BRIAN M. officer: Chief Financial Officer officer: Chief Financial Officer
Voting Common Stock 2,842 $1.51 $4,277 Purchase
SOUTHWELL DAVID P director, officer: Chief Executive Officer director, officer: Chief Execut..
Voting Common Stock 10,000 $3.55 $35,480 Purchase
SOUTHWELL DAVID P director, officer: Chief Executive Officer director, officer: Chief Execut..
Voting Common Stock 15,000 $3.62 $54,345 Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 22,983 $1.99 $45,621 Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 2,882 $1.99 $5,721 Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 758,094 $1.95 $1,478,283 Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 95,060 $1.95 $185,367 Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 101,831 $1.93 $196,941 Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 12,769 $1.93 $24,695 Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 325,373 $1.7 $553,134 Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 40,800 $1.7 $69,360 Purchase
SILVER BRIAN M. officer: Chief Financial Officer officer: Chief Financial Officer
Voting Common Stock 15,000 $3.4 $50,985 Option
SOUTHWELL DAVID P director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 48,670 $1.97 $95,880 Option
SOUTHWELL DAVID P director, officer: Chief Executive Officer director, officer: Chief Execut..
Voting Common Stock 48,670 $1.97 $95,880 Purchase
ZDRAVESKI ZORAN officer: Chief Legal Officer officer: Chief Legal Officer
Voting Common Stock 4,716 $7.48 $35,257 Purchase
SILVER BRIAN M. officer: Chief Financial Officer officer: Chief Financial Officer
Voting Common Stock 5,000 $6.32 $31,585 Purchase
MACBEATH GAVIN officer: Chief Scientific Officer officer: Chief Scientific Officer
Voting Common Stock 57 $6.19 $353 Purchase
MACBEATH GAVIN officer: Chief Scientific Officer officer: Chief Scientific Officer
Voting Common Stock 4,943 $6.22 $30,745 Purchase
SILVER BRIAN M. officer: Chief Financial Officer officer: Chief Financial Officer
Voting Common Stock 5,885 $8.48 $49,928 Purchase
SOUTHWELL DAVID P
Voting Common Stock 11,000 $8.73 $96,063 Purchase
DESMARAIS WILLIAM
Voting Common Stock 2,500 $9.08 $22,708 Purchase
BAKER BROS. ADVISORS LP
Common Stock 1,425,000 $15 $21,375,000 Purchase
SILVER BRIAN M.
Voting Common Stock 1,000 $15 $15,000 Purchase
WESTPHAL CHRISTOPH H
Voting Common Stock 133,333 $15 $1,999,995