Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 230,321 $0.6 $138,193 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 80 $0.8 $64 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 8,015 $0.8 $6,412 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 54,181 $0.84 $45,512 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 20,903 $0.82 $17,140 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 76,200 $0.79 $60,198 Purchase
LYNX1 CAPITAL MANAGEMENT LP 10 percent owner 10 percent owner
Common Stock 29,300 $0.67 $19,660 Purchase
LYNX1 CAPITAL MANAGEMENT LP 10 percent owner 10 percent owner
Common Stock 167,055 $0.71 $118,275 Purchase
LYNX1 CAPITAL MANAGEMENT LP 10 percent owner 10 percent owner
Common stock, $0.0001 par value per share ("Common Stock") 259,998 $0.56 $146,639 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 39,300 $0.71 $27,903 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 25,631 $0.73 $18,711 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 111,400 $0.73 $81,322 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 63,100 $0.74 $46,694 Sale
BORTHWICK KATHLEEN officer: SVP, INTERIM CFO officer: SVP, INTERIM CFO
Common Stock 1,470 $0.97 $1,426 Sale
FORMAN MARK S officer: CHIEF MEDICAL OFFICER officer: CHIEF MEDICAL OFFICER
Common Stock 1,638 $0.97 $1,589 Option
BORTHWICK KATHLEEN officer: SVP, INTERIM CFO officer: SVP, INTERIM CFO
Common Stock 4,000 N/A N/A Option
BORTHWICK KATHLEEN officer: SVP, INTERIM CFO officer: SVP, INTERIM CFO
Restricted Stock Unit 4,000 N/A N/A Option
FORMAN MARK S officer: CHIEF MEDICAL OFFICER officer: CHIEF MEDICAL OFFICER
Common Stock 5,000 N/A N/A Option
FORMAN MARK S officer: CHIEF MEDICAL OFFICER officer: CHIEF MEDICAL OFFICER
Restricted Stock Unit 5,000 N/A N/A Sale
FORMAN MARK S officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 15,813 $0.91 $14,390 Sale
BORTHWICK KATHLEEN officer: SVP, Interim CFO officer: SVP, Interim CFO
Common Stock 10,672 $0.91 $9,712 Sale
CALE EDGAR B. officer: GC & Corporate Secretary officer: GC & Corporate Secretary
Common Stock 15,813 $0.91 $14,390 Option
FORMAN MARK S officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 50,000 N/A N/A Option
FORMAN MARK S officer: Chief Medical Officer officer: Chief Medical Officer
Restricted Stock Unit 50,000 N/A N/A Option
BORTHWICK KATHLEEN officer: SVP, Interim CFO officer: SVP, Interim CFO
Common Stock 30,000 N/A N/A Option
BORTHWICK KATHLEEN officer: SVP, Interim CFO officer: SVP, Interim CFO
Restricted Stock Unit 30,000 N/A N/A Option
CALE EDGAR B. officer: GC & Corporate Secretary officer: GC & Corporate Secretary
Common Stock 50,000 N/A N/A Option
CALE EDGAR B. officer: GC & Corporate Secretary officer: GC & Corporate Secretary
Restricted Stock Unit 50,000 N/A N/A Sale
KING SIMONA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 11,453 $0.88 $10,079 Option
KING SIMONA officer: Chief Financial Officer officer: Chief Financial Officer
Restricted Stock Units 31,250 N/A N/A Option
KING SIMONA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 31,250 N/A N/A Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 575,195 $0.84 $483,164 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 617,382 $0.84 $518,601 Sale
FOTOPOULOS ALEXANDROS officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 4,052 $0.93 $3,781 Option
FOTOPOULOS ALEXANDROS officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 12,500 N/A N/A Option
FOTOPOULOS ALEXANDROS officer: Chief Technical Officer officer: Chief Technical Officer
Restricted Stock Units 12,500 N/A N/A Option
KING SIMONA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 6,250 N/A N/A Sale
KING SIMONA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 2,053 $1.05 $2,156 Option
KING SIMONA officer: Chief Financial Officer officer: Chief Financial Officer
Restricted Stock Units 6,250 N/A N/A Sale
KAPADIA SANDIP director director
Common Stock 5,000 $1.19 $5,965 Option
FOTOPOULOS ALEXANDROS officer: Chief Technical Officer officer: Chief Technical Officer
Restricted Stock Units 12,500 N/A N/A Option
FOTOPOULOS ALEXANDROS officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 12,500 N/A N/A Sale
FOTOPOULOS ALEXANDROS officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 3,720 $1.33 $4,948 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 303,500 $1.94 $588,790 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 221,500 $1.93 $427,495 Purchase
GOLDSMITH BRUCE A director, officer: CEO and President director, officer: CEO and Pres..
Common Stock 10,000 $3.15 $31,500 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 369,100 $5.42 $2,000,522 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 43,300 $5.11 $221,263 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 114,700 $5.46 $626,262 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 10,300 $5.6 $57,680