Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 41,800 $5.52 $230,736 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 100,000 $5.65 $565,000 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 8,200 $5.53 $45,346 Option
QUIGLEY JILL M. officer: Chief Operating Officer officer: Chief Operating Officer
Employee Stock Option (right to buy) 71,975 $0.23 $16,554 Option
QUIGLEY JILL M. officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 71,975 $0.23 $16,554 Purchase
GOLDSMITH BRUCE A director, officer: CEO and President director, officer: CEO and Pres..
Common Stock 2,000 $13.12 $26,230 Purchase
MORRIS RICHARD STEVEN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 2,171 N/A N/A Option
ROMANO GARY officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 10,000 $8.07 $80,700 Sale
ROMANO GARY officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 10,000 $21.41 $214,080 Option
ROMANO GARY officer: Chief Medical Officer officer: Chief Medical Officer
Employee Stock Option (right to buy) 10,000 $8.07 $80,700 Sale
ROMANO GARY officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 10,000 $21.41 $214,080 Sale
QUIGLEY JILL M. officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 1,300 $30.01 $39,012 Sale
QUIGLEY JILL M. officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 16,298 $30.1 $490,570 Purchase
COUNTOURIOTIS ATHENA director director
Common Stock 10,000 $14.98 $149,750 Purchase
CALE EDGAR B. officer: GC and Corporate Secretary officer: GC and Corporate Secre..
Common Stock 2,000 $18 $36,000 Purchase
COUNTOURIOTIS ATHENA director director
Common Stock 8,900 $18 $160,200 Purchase
FOTOPOULOS ALEXANDROS officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 5,500 $18 $99,000 Purchase
GOLDSMITH BRUCE A director, officer: CEO and President director, officer: CEO and Pres..
Common Stock 1,100 $18 $19,800 Purchase
ISLAM SAQIB director director
Common Stock 5,000 $18 $90,000 Purchase
KAPADIA SANDIP director director
Common Stock 5,000 $18 $90,000 Purchase
MORRIS RICHARD STEVEN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 400 $18 $7,200 Purchase
QUIGLEY JILL M. officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 2,500 $18 $45,000 Purchase
RATCLIFFE LIAM director director
Common Stock 552,800 $18 $9,950,400 Purchase
YAMADA TADATAKA director director
Common Stock 6,500 $18 $117,000 Purchase
HERON PATRICK J director, 10 percent owner director, 10 percent owner
Common Stock 550,000 $18 $9,900,000 Purchase
WOIWODE THOMAS director, 10 percent owner director, 10 percent owner
Common Stock 225,000 $18 $4,050,000 Purchase
FRAZIER LIFE SCIENCES IX, L.P. 10 percent owner 10 percent owner
Common Stock 550,000 $18 $9,900,000 Purchase
VERSANT VENTURE CAPITAL VI, L.P. 10 percent owner 10 percent owner
Common Stock 225,000 $18 $4,050,000 Purchase
RATCLIFFE LIAM director director
Common Stock 552,800 $18 $9,950,400 Purchase
QUIGLEY JILL M. officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 2,500 $18 $45,000 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 373,300 $18 $6,719,400