Purchase
ADAR1 CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 2,243 $15.88 $35,623 Purchase
ADAR1 CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 757 $15.88 $12,023 Purchase
ADAR1 CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 3,000 $14.89 $44,679 Purchase
GERAGHTY JAMES A director director
Series F Preferred Stock, par value $0.001 per share 1 $1 $1 Purchase
KIRITSY CHRISTOPHER P director director
Common Stock 10,000 $0.85 $8,500 Purchase
DEMUTH TIM officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 6,000 $1.71 $10,260 Option
OLWILL SHANE officer: Chief Development Officer officer: Chief Development Offi..
Stock Option (right to buy) 38,400 $1.52 $58,368 Sale
OLWILL SHANE officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 9,200 $5 $46,000 Sale
OLWILL SHANE officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 29,200 $5.15 $150,380 Option
OLWILL SHANE officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 38,400 $1.52 $58,368 Sale
AQUILO CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock, $0.001 par value 1,900,000 N/A N/A Sale
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 50,000 N/A N/A Purchase
KIRITSY CHRISTOPHER P director director
Common Stock 5,000 N/A N/A Purchase
GERAGHTY JAMES A director director
Common Stock 10,000 N/A N/A Sale
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 1,000,000 N/A N/A Sale
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 1,000,000 $6.35 $6,350,000 Option
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Stock Option (right to buy) 6,057 N/A N/A Sale
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 7,897 N/A N/A Option
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 7,897 N/A N/A Sale
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 7,897 N/A N/A Sale
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 1,709,620 N/A N/A Option
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Stock Option (right to buy) 27,241 N/A N/A Sale
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 147,635 N/A N/A Option
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 147,635 N/A N/A Option
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 147,635 $2.35 $346,942 Purchase
REINE ALLAN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 20,000 N/A N/A Purchase
GERAGHTY JAMES A director director
Common Stock 10,000 N/A N/A Purchase
REINE ALLAN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 45,000 N/A N/A Option
KIRITSY CHRISTOPHER P director director
Stock Option (right to buy) 5,000 N/A N/A Option
KIRITSY CHRISTOPHER P director director
Common Stock 5,000 N/A N/A Purchase
MATIS LOUIS officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 7,915 N/A N/A Purchase
DEPTULA-HICKS DARLENE M officer: SVP, Chief Financial Offi.. officer: SVP, Chief Financial O..
Common Stock 5,000 N/A N/A Purchase
MATIS LOUIS officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 2,085 N/A N/A Purchase
YODER STEPHEN S. director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 6,000 N/A N/A Purchase
KHUONG CHAU QUANG director, 10 percent owner director, 10 percent owner
Common Stock 500,000 N/A N/A Purchase
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 500,000 N/A N/A