Option
MAURO DAVID J
Common Stock 9,617 $1.89 $18,176 Sale
MAURO DAVID J
Common Stock 9,617 $38.36 $368,860 Option
MAURO DAVID J
Employee Stock Option (right to buy) 9,617 $1.89 $18,176 Option
MOROSINI DEBORAH officer: EVP, Chief of Clinical Affairs officer: EVP, Chief of Clinical..
Common Stock 100 N/A N/A Sale
MOROSINI DEBORAH officer: EVP, Chief of Clinical Affairs officer: EVP, Chief of Clinical..
Common Stock 100 N/A N/A Sale
SCHERLE PEGGY
Common Stock 4,630 N/A N/A Option
SCHERLE PEGGY
Employee Stock Option (right to buy) 4,630 N/A N/A Option
MOROSINI DEBORAH officer: EVP, Chief of Clinical Affairs officer: EVP, Chief of Clinical..
Employee Stock Option (right to buy) 100 N/A N/A Sale
PIERCE CHRISTOPHER officer: EVP and Chief of Business Oper officer: EVP and Chief of Busin..
Common Stock 200 N/A N/A Option
PIERCE CHRISTOPHER officer: EVP and Chief of Business Oper officer: EVP and Chief of Busin..
Employee Stock Option (right to buy) 200 N/A N/A Sale
MAURO DAVID J
Common Stock 15,383 $39.36 $605,429 Sale
SCHERLE PEGGY
Common Stock 15,370 $39.65 $609,390 Option
MAURO DAVID J
Common Stock 15,383 $1.89 $29,074 Sale
MAURO DAVID J
Common Stock 15,383 N/A N/A Option
MAURO DAVID J
Employee Stock Option (right to buy) 15,383 $1.89 $29,074 Option
PIERCE CHRISTOPHER officer: EVP and Chief of Business Oper officer: EVP and Chief of Busin..
Employee Stock Option (right to buy) 828 $1.89 $1,565 Option
MOROSINI DEBORAH officer: EVP, Chief of Clinical Affairs officer: EVP, Chief of Clinical..
Common Stock 1,000 $1.89 $1,890 Sale
MOROSINI DEBORAH officer: EVP, Chief of Clinical Affairs officer: EVP, Chief of Clinical..
Common Stock 1,000 $1.89 $1,890 Option
MOROSINI DEBORAH officer: EVP, Chief of Clinical Affairs officer: EVP, Chief of Clinical..
Employee Stock Option (right to buy) 1,000 $1.89 $1,890 Sale
PIERCE CHRISTOPHER officer: EVP and Chief of Business Oper officer: EVP and Chief of Busin..
Common Stock 828 $1.89 $1,565 Sale
SCHERLE PEGGY
Common Stock 15,370 $39.65 $609,390 Option
SCHERLE PEGGY
Employee Stock Option (right to buy) 15,370 N/A N/A Option
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 10,376 N/A N/A Option
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Non-Qualified Stock Options (right to buy) 5,188 $12.85 $66,666 Option
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 10,376 $12.85 $133,332 Purchase
BONITA DAVID P director, 10 percent owner director, 10 percent owner
Non-Voting Common Stock 41,700 $60 $2,502,000 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Non-Voting Common Stock 41,700 N/A N/A Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Non-Voting Common Stock 166,666 $30 $4,999,980 Purchase
COMBS ANDREW officer: EVP, Head of Chemistry officer: EVP, Head of Chemistry
Common Stock 1,000 N/A N/A Purchase
MOROSINI DEBORAH officer: EVP, Chief of Clinical Affairs officer: EVP, Chief of Clinical..
Common Stock 444 N/A N/A Purchase
PIERCE CHRISTOPHER officer: EVP and Chief of Business Oper officer: EVP and Chief of Busin..
Common Stock 3,750 N/A N/A Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 1,578,947 N/A N/A Purchase
DIER MARDI director director
Common Stock 10,000 N/A N/A Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,236,800 N/A N/A Purchase
BONITA DAVID P director, 10 percent owner director, 10 percent owner
Common Stock 1,236,800 N/A N/A Purchase
BONITA DAVID P director, 10 percent owner director, 10 percent owner
Series C Preferred Stock 1,033,084 N/A N/A Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Series C Preferred Stock 1,033,084 N/A N/A Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Series C Preferred Stock 1,033,084 N/A N/A Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Series B Preferred Stock 3,681,822 $6.43 $23,655,706 Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Series B Preferred Stock 3,681,822 N/A N/A Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Series B Preferred Stock 3,681,822 N/A N/A Purchase
FRIEDMAN PAUL A director director
Series B Preferred Stock 76,288 N/A N/A Purchase
BONITA DAVID P director, 10 percent owner director, 10 percent owner
Series B Preferred Stock 3,681,822 N/A N/A