Sale
SMITH BRANDON S. officer: Chief Operating Officer officer: Chief Operating Officer
Ordinary Shares, par value $0.01 per share 2,226 $58.22 $129,602 Sale
SMITH BRANDON S. officer: Chief Operating Officer officer: Chief Operating Officer
Ordinary Shares, par value $0.01 per share 1,373 $59.15 $81,217 Sale
SMITH BRANDON S. officer: Chief Operating Officer officer: Chief Operating Officer
Ordinary Shares, par value $0.01 per share 401 $59.91 $24,025 Option
GARREN HIDEKI officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 2,000 $24.9 $49,800 Option
GARREN HIDEKI officer: Chief Medical Officer officer: Chief Medical Officer
Ordinary Shares, par value $0.01 per share 2,000 $24.9 $49,800 Sale
GARREN HIDEKI officer: Chief Medical Officer officer: Chief Medical Officer
Ordinary Shares, par value $0.01 per share 878 $58.15 $51,059 Sale
GARREN HIDEKI officer: Chief Medical Officer officer: Chief Medical Officer
Ordinary Shares, par value $0.01 per share 748 $58.93 $44,079 Sale
GARREN HIDEKI officer: Chief Medical Officer officer: Chief Medical Officer
Ordinary Shares, par value $0.01 per share 374 $59.74 $22,342 Option
SMITH BRANDON S. officer: Chief Operating Officer officer: Chief Operating Officer
Stock Option (Right to Buy) 4,000 $11.12 $44,480 Option
ZAGO WAGNER M. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 4,000 $12.15 $48,600 Option
ZAGO WAGNER M. officer: Chief Scientific Officer officer: Chief Scientific Officer
Ordinary Shares, par value $0.01 per share 4,000 $12.15 $48,600 Sale
ZAGO WAGNER M. officer: Chief Scientific Officer officer: Chief Scientific Officer
Ordinary Shares, par value $0.01 per share 3,771 $66.98 $252,593 Sale
ZAGO WAGNER M. officer: Chief Scientific Officer officer: Chief Scientific Officer
Ordinary Shares, par value $0.01 per share 229 $68.07 $15,589 Option
KARP CAROL D. officer: Chief Regulatory Officer officer: Chief Regulatory Officer
Stock Option (Right to Buy) 5,000 $12.15 $60,750 Option
KARP CAROL D. officer: Chief Regulatory Officer officer: Chief Regulatory Officer
Ordinary Shares, par value $0.01 per share 5,000 $12.15 $60,750 Sale
KARP CAROL D. officer: Chief Regulatory Officer officer: Chief Regulatory Officer
Ordinary Shares, par value $0.01 per share 4,672 $66.95 $312,786 Sale
KARP CAROL D. officer: Chief Regulatory Officer officer: Chief Regulatory Officer
Ordinary Shares, par value $0.01 per share 328 $67.95 $22,288 Option
MALECEK MICHAEL J officer: Chief Legal Officer officer: Chief Legal Officer
Stock Option (Right to Buy) 5,000 $10.27 $51,350 Option
MALECEK MICHAEL J officer: Chief Legal Officer officer: Chief Legal Officer
Ordinary Shares, par value $0.01 per share 5,000 $10.27 $51,350 Sale
MALECEK MICHAEL J officer: Chief Legal Officer officer: Chief Legal Officer
Ordinary Shares, par value $0.01 per share 2,477 $61.78 $153,032 Sale
MALECEK MICHAEL J officer: Chief Legal Officer officer: Chief Legal Officer
Ordinary Shares, par value $0.01 per share 1,903 $62.69 $119,297 Sale
MALECEK MICHAEL J officer: Chief Legal Officer officer: Chief Legal Officer
Ordinary Shares, par value $0.01 per share 620 $63.4 $39,309 Option
WALKER KARIN L officer: Chief Accounting Officer officer: Chief Accounting Officer
Stock Option (right to buy) 5,000 $15.04 $75,200 Option
WALKER KARIN L officer: Chief Accounting Officer officer: Chief Accounting Officer
Ordinary Shares, par value $0.01 per share 5,000 $15.04 $75,200 Sale
WALKER KARIN L officer: Chief Accounting Officer officer: Chief Accounting Officer
Ordinary Shares, par value $0.01 per share 3,966 $68.96 $273,483 Sale
WALKER KARIN L officer: Chief Accounting Officer officer: Chief Accounting Officer
Ordinary Shares, par value $0.01 per share 1,034 $70.08 $72,459 Option
GARREN HIDEKI officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 2,000 $24.9 $49,800 Option
GARREN HIDEKI officer: Chief Medical Officer officer: Chief Medical Officer
Ordinary Shares, par value $0.01 per share 2,000 $24.9 $49,800 Sale
GARREN HIDEKI officer: Chief Medical Officer officer: Chief Medical Officer
Ordinary Shares, par value $0.01 per share 1,908 $67.48 $128,752 Sale
GARREN HIDEKI officer: Chief Medical Officer officer: Chief Medical Officer
Ordinary Shares, par value $0.01 per share 92 $68.2 $6,274 Option
SMITH BRANDON S. officer: Chief Operating Officer officer: Chief Operating Officer
Stock Option (Right to Buy) 4,000 $11.12 $44,480 Option
SMITH BRANDON S. officer: Chief Operating Officer officer: Chief Operating Officer
Ordinary Shares, par value $0.01 per share 4,000 $11.12 $44,480 Sale
SMITH BRANDON S. officer: Chief Operating Officer officer: Chief Operating Officer
Ordinary Shares, par value $0.01 per share 3,200 $67.4 $215,667 Sale
SMITH BRANDON S. officer: Chief Operating Officer officer: Chief Operating Officer
Ordinary Shares, par value $0.01 per share 800 $67.95 $54,358 Option
KARP CAROL D. officer: Chief Regulatory Officer officer: Chief Regulatory Officer
Stock Option (Right to Buy) 5,000 $12.15 $60,750 Option
KARP CAROL D. officer: Chief Regulatory Officer officer: Chief Regulatory Officer
Ordinary Shares, par value $0.01 per share 5,000 $12.15 $60,750 Sale
KARP CAROL D. officer: Chief Regulatory Officer officer: Chief Regulatory Officer
Ordinary Shares, par value $0.01 per share 3,966 $67.98 $269,609 Sale
KARP CAROL D. officer: Chief Regulatory Officer officer: Chief Regulatory Officer
Ordinary Shares, par value $0.01 per share 1,034 $68.69 $71,028 Option
ZAGO WAGNER M. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 4,000 $12.15 $48,600 Option
ZAGO WAGNER M. officer: Chief Scientific Officer officer: Chief Scientific Officer
Ordinary Shares, par value $0.01 per share 4,000 $12.15 $48,600 Sale
ZAGO WAGNER M. officer: Chief Scientific Officer officer: Chief Scientific Officer
Ordinary Shares, par value $0.01 per share 2,991 $67.99 $203,343 Sale
ZAGO WAGNER M. officer: Chief Scientific Officer officer: Chief Scientific Officer
Ordinary Shares, par value $0.01 per share 1,009 $68.69 $69,305 Option
SELKOE DENNIS J. director director
Stock Option (Right to Buy) 5,000 $11.33 $56,650 Option
SELKOE DENNIS J. director director
Ordinary Shares, par value $0.01 per share 5,000 $11.33 $56,650 Sale
SELKOE DENNIS J. director director
Ordinary Shares, par value $0.01 per share 5,000 $67.43 $337,150 Option
MALECEK MICHAEL J officer: Chief Legal Officer officer: Chief Legal Officer
Stock Option (Right to Buy) 5,000 $10.27 $51,350 Option
MALECEK MICHAEL J officer: Chief Legal Officer officer: Chief Legal Officer
Ordinary Shares, par value $0.01 per share 5,000 $10.27 $51,350 Sale
MALECEK MICHAEL J officer: Chief Legal Officer officer: Chief Legal Officer
Ordinary Shares, par value $0.01 per share 1,240 $69.07 $85,644 Sale
MALECEK MICHAEL J officer: Chief Legal Officer officer: Chief Legal Officer
Ordinary Shares, par value $0.01 per share 3,050 $69.89 $213,177 Sale
MALECEK MICHAEL J officer: Chief Legal Officer officer: Chief Legal Officer
Ordinary Shares, par value $0.01 per share 710 $70.84 $50,296