| Utility: Glucuronylation as a new acidic post-translational modification on therapeutic monoclonal antibodies Filling date: 5 Sep 2025 Issue date: 21 Jun 2022 | 29 Jan 2019 | 21 Jun 2022 |
| Utility: Anti-C5 antibody combinations and uses thereof Filling date: 5 Sep 2025 Issue date: 21 Jun 2022 | 12 Dec 2018 | 21 Jun 2022 |
| Utility: Methods Of Treating Metabolic Disorders And Cardiovascular Disease With Inhibin Subunit Beta E (INHBE) Inhibitors Filling date: 5 Sep 2025 Issue date: 16 Jun 2022 | 13 Dec 2021 | 16 Jun 2022 |
| Utility: HUMAN ANTIBODIES THAT BIND RET AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 16 Jun 2022 | 9 Apr 2020 | 16 Jun 2022 |
| Utility: Methods for analysis of viral capsid protein composition Filling date: 5 Sep 2025 Issue date: 14 Jun 2022 | 10 Jun 2020 | 14 Jun 2022 |
| Utility: Use of Raman spectroscopy in downstream purification Filling date: 5 Sep 2025 Issue date: 14 Jun 2022 | 26 Aug 2019 | 14 Jun 2022 |
| Utility: CELL CULTURE MEDIUM FOR EUKARYOTIC CELLS Filling date: 5 Sep 2025 Issue date: 9 Jun 2022 | 22 Feb 2022 | 9 Jun 2022 |
| Utility: NON-HUMAN ANIMALS HAVING AN IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION THAT INCLUDES AN ENGINEERED DIVERSITY CLUSTER AND USES THEREOF Filling date: 5 Sep 2025 Issue date: 9 Jun 2022 | 21 Feb 2022 | 9 Jun 2022 |
| Utility: RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN MICE Filling date: 5 Sep 2025 Issue date: 9 Jun 2022 | 19 Jan 2022 | 9 Jun 2022 |
| Utility: MICE THAT MAKE VL BINDING PROTEINS Filling date: 5 Sep 2025 Issue date: 9 Jun 2022 | 14 Dec 2021 | 9 Jun 2022 |
| Utility: Methods Of Identifying Subjects Having An Increased Risk Of Developing A Coronavirus Infection And Treatment Thereof Filling date: 5 Sep 2025 Issue date: 9 Jun 2022 | 3 Dec 2021 | 9 Jun 2022 |
| Utility: Quantitation and modeling of quality attributes of therapeutic monoclonal antibodies Filling date: 5 Sep 2025 Issue date: 7 Jun 2022 | 31 Jan 2019 | 7 Jun 2022 |
| Utility: Method of treating an allergy with allergen-specific monoclonal antibodies Filling date: 5 Sep 2025 Issue date: 7 Jun 2022 | 15 Dec 2017 | 7 Jun 2022 |
| Utility: Room temperature stable lyophilized protein Filling date: 5 Sep 2025 Issue date: 7 Jun 2022 | 6 Oct 2017 | 7 Jun 2022 |
| Utility: Methods of making multispecific antigen-binding molecules Filling date: 5 Sep 2025 Issue date: 7 Jun 2022 | 28 Apr 2017 | 7 Jun 2022 |
| Utility: SYSTEM AND METHOD FOR CHARACTERIZING DRUG PRODUCT IMPURITIES Filling date: 5 Sep 2025 Issue date: 2 Jun 2022 | 22 Feb 2022 | 2 Jun 2022 |
| Utility: METHODS FOR TREATING ASTHMA IN PEDIATRIC SUBJECTS BY ADMINISTERING AN IL-4R ANTAGONIST Filling date: 5 Sep 2025 Issue date: 2 Jun 2022 | 4 Oct 2021 | 2 Jun 2022 |
| Utility: Biologically active molecules, conjugates thereof, and therapeutic uses Filling date: 5 Sep 2025 Issue date: 31 May 2022 | 10 Jan 2020 | 31 May 2022 |
| Utility: Methods for analysis of viral capsid protein composition Filling date: 5 Sep 2025 Issue date: 31 May 2022 | 24 Oct 2019 | 31 May 2022 |
| Utility: ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME Filling date: 5 Sep 2025 Issue date: 26 May 2022 | 8 Feb 2022 | 26 May 2022 |
| Utility: ANTI-IL36R ANTIBODIES Filling date: 5 Sep 2025 Issue date: 26 May 2022 | 1 Feb 2022 | 26 May 2022 |
| Utility: ANTI-FGFR2 ANTIBODIES AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 26 May 2022 | 21 Oct 2021 | 26 May 2022 |
| Utility: ANTI-ANGPTL3 ANTIBODIES AND USES THEREOF Filling date: 5 Sep 2025 Issue date: 19 May 2022 | 27 Jan 2022 | 19 May 2022 |
| Utility: Genotyping By Sequencing Filling date: 5 Sep 2025 Issue date: 19 May 2022 | 19 Nov 2021 | 19 May 2022 |
| Utility: UNBIASED AND HIGH-THROUGHPUT IDENTIFICATION AND QUANTIFICATION OF HOST CELL PROTEIN IMPURITIES BY AUTOMATED ITERATIVE LC-MS/MS (HCP-AIMS) FOR THERAPEUTIC PROTEIN DEVELOPMENT Filling date: 5 Sep 2025 Issue date: 19 May 2022 | 17 Nov 2021 | 19 May 2022 |
| Utility: COMPOSITIONS AND METHODS FOR USING BISPECIFIC ANTIBODIES TO BIND COMPLEMENT AND A TARGET ANTIGEN Filling date: 5 Sep 2025 Issue date: 19 May 2022 | 12 Feb 2020 | 19 May 2022 |
| Utility: Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (SCAP) inhibitors Filling date: 5 Sep 2025 Issue date: 17 May 2022 | 19 Mar 2020 | 17 May 2022 |
| Utility: Methods and systems for chromatography data analysis Filling date: 5 Sep 2025 Issue date: 17 May 2022 | 21 Feb 2020 | 17 May 2022 |
| Utility: Serum-free cell culture medium Filling date: 5 Sep 2025 Issue date: 17 May 2022 | 14 Jan 2020 | 17 May 2022 |
| Utility: Anti-CD3 Antibodies, Bispecific Antigen-Binding Molecules that Bind CD3 and CD20, and Uses Thereof Filling date: 5 Sep 2025 Issue date: 12 May 2022 | 23 Jun 2021 | 12 May 2022 |
| Utility: Methods and compositions for targeted genetic modification through single-step multiple targeting Filling date: 5 Sep 2025 Issue date: 10 May 2022 | 18 Dec 2015 | 10 May 2022 |
| Utility: Multifunctional alleles Filling date: 5 Sep 2025 Issue date: 3 May 2022 | 1 Jul 2019 | 3 May 2022 |
| Utility: BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDES AND PROTEIN CONJUGATES THEREOF Filling date: 5 Sep 2025 Issue date: 14 Apr 2022 | 5 Oct 2021 | 14 Apr 2022 |
| Utility: RODENT ANIMALS EXPRESSING HUMAN CR1 Filling date: 5 Sep 2025 Issue date: 7 Apr 2022 | 30 Sep 2021 | 7 Apr 2022 |
| Utility: Methods for treating atopic dermatitis by administering an IL-4R inhibitor Filling date: 5 Sep 2025 Issue date: 5 Apr 2022 | 10 May 2019 | 5 Apr 2022 |
| Utility: Polymer protein microparticles Filling date: 5 Sep 2025 Issue date: 5 Apr 2022 | 6 Mar 2017 | 5 Apr 2022 |
| Utility: ANTIBODY-DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF Filling date: 5 Sep 2025 Issue date: 31 Mar 2022 | 14 Sep 2021 | 31 Mar 2022 |
| Utility: ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME Filling date: 5 Sep 2025 Issue date: 31 Mar 2022 | 26 Aug 2021 | 31 Mar 2022 |
| Utility: Cell culture medium for eukaryotic cells Filling date: 5 Sep 2025 Issue date: 29 Mar 2022 | 24 Mar 2021 | 29 Mar 2022 |
| Utility: Anti-VEGF protein compositions and methods for producing the same Filling date: 5 Sep 2025 Issue date: 29 Mar 2022 | 24 Mar 2021 | 29 Mar 2022 |
| Utility: METHODS FOR TREATING OR PREVENTING ATHEROSCLEROSIS BY ADMINISTERING AN INHIBITOR OF ANGPTL3 Filling date: 5 Sep 2025 Issue date: 24 Mar 2022 | 29 Nov 2021 | 24 Mar 2022 |
| Utility: ANTIGEN-BINDING MOLECULES THAT BIND CD38 AND/OR CD28, AND USES THEREOF Filling date: 5 Sep 2025 Issue date: 24 Mar 2022 | 17 Sep 2021 | 24 Mar 2022 |
| Utility: IDENTIFICATION AND PRODUCTION OF ANTIGEN-SPECIFIC ANTIBODIES Filling date: 5 Sep 2025 Issue date: 24 Mar 2022 | 10 Sep 2021 | 24 Mar 2022 |
| Utility: Treatment Of Ophthalmic Conditions With Angiopoietin-Like 7 (ANGPTL7) Inhibitors Filling date: 5 Sep 2025 Issue date: 24 Mar 2022 | 27 Jul 2021 | 24 Mar 2022 |
| Utility: METHODS FOR BINDING SITE IDENTIFICATION USING HYDROGEN EXCHANGE MASS SPECTROMETRY Filling date: 5 Sep 2025 Issue date: 17 Mar 2022 | 11 Sep 2021 | 17 Mar 2022 |
| Utility: BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDE DERIVATIVES AND PROTEIN CONJUGATES THEREOF FOR USE AS LXR AGONISTS Filling date: 5 Sep 2025 Issue date: 17 Mar 2022 | 19 Nov 2019 | 17 Mar 2022 |
| Utility: Systems and methods for sequencing T cell receptors and uses thereof Filling date: 5 Sep 2025 Issue date: 15 Mar 2022 | 11 Dec 2017 | 15 Mar 2022 |
| Utility: TREATMENT OF INFLAMMATORY CONDITIONS BY DELIVERY OF INTERLEUKIN-1 RECEPTOR ANTAGONIST FUSION PROTEIN Filling date: 5 Sep 2025 Issue date: 10 Mar 2022 | 16 Nov 2021 | 10 Mar 2022 |
| Utility: GPR156 Variants And Uses Thereof Filling date: 5 Sep 2025 Issue date: 10 Mar 2022 | 23 Sep 2021 | 10 Mar 2022 |
| Utility: METHOD FOR DETECTING HOST CELL PROTEINS IN THERAPEUTIC ANTIBODIES BY COMBINING TRYPSIN DIGESTION, CHROMATOGRAPHY GRADIENTS, AND BOXCAR MASS SPECTROMETRY Filling date: 5 Sep 2025 Issue date: 10 Mar 2022 | 8 Sep 2021 | 10 Mar 2022 |
