Option
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Employee Stock Option (Right to Buy) 7,500 N/A N/A Option
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 7,500 N/A N/A Option
SMITH HUNTER C officer: Chief Financial Officer officer: Chief Financial Officer
Employee Stock Option (Right to Buy) 10,000 N/A N/A Option
SMITH HUNTER C officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 10,000 N/A N/A Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 5,000 N/A N/A Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Employee Stock Option (Right to Buy) 5,000 N/A N/A Sale
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 5,000 N/A N/A Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Employee Stock Option (Right to Buy) 5,000 N/A N/A Sale
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 5,000 N/A N/A Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 5,000 N/A N/A Sale
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 5,000 N/A N/A Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 5,000 N/A N/A Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Employee Stock Option (Right to Buy) 5,000 N/A N/A Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 10,000 N/A N/A Sale
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 10,000 N/A N/A Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Employee Stock Option (Right to Buy) 10,000 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 2,329 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 7,961 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 1,506 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 7,782 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 1,814 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 635 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 918 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 12,002 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 3,934 N/A N/A Option
SMITH HUNTER C officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 3,000 N/A N/A Option
SMITH HUNTER C officer: Chief Financial Officer officer: Chief Financial Officer
Employee Stock Option (Right to Buy) 3,000 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 105 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 15,674 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 10,115 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 662 N/A N/A Sale
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 200 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 563 N/A N/A Sale
GOTTESDIENER KEITH MICHAEL director, officer: CEO & Presid.. director, officer: CEO & Presid..
Common Stock 16,500 N/A N/A Sale
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 38,000 N/A N/A Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 28,200 $6.54 $184,513 Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Employee Stock Option (Right to Buy) 28,200 N/A N/A Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 28,200 N/A N/A Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Employee Stock Option (Right to Buy) 28,200 $6.54 $184,513 Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Employee Stock Option (Right to Buy) 21,800 N/A N/A Sale
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 31,800 N/A N/A Option
VAN DER PLOEG LEONARDUS H.T. officer: Chief Scientific Off.. officer: Chief Scientific Officer
Common Stock 21,800 N/A N/A Option
SMITH HUNTER C officer: Chief Financial Officer officer: Chief Financial Officer
Employee Stock Option (Right to Buy) 3,000 N/A N/A Option
SMITH HUNTER C officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 3,000 N/A N/A Option
DESIKAN NITHYA officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 14,534 N/A N/A Option
DESIKAN NITHYA officer: Chief Commercial Officer officer: Chief Commercial Officer
Employee Stock Option (Right to Buy) 14,534 N/A N/A Purchase
FOLEY TODD director director
Common Stock 378,501 N/A N/A Sale
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 19,580 $30.67 $600,519 Sale
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 19,580 N/A N/A Sale
ORBIMED ADVISORS LLC 10 percent owner, other: See Remarks 10 percent owner, other: See Re..
Common Stock 62,500 N/A N/A