Option
ESPOSITO PAMELA director director
Stock Option (Right to Buy) 2,500 $29.55 $73,875 Option
ESPOSITO PAMELA director director
Common Stock 2,500 $29.55 $73,875 Sale
ESPOSITO PAMELA director director
Common Stock 2,500 $49 $122,500 Option
ESPOSITO PAMELA director director
Stock Option (Right to Buy) 8,500 $29.55 $251,175 Option
ESPOSITO PAMELA director director
Common Stock 5,000 $14.18 $70,900 Option
ESPOSITO PAMELA director director
Common Stock 8,500 $29.55 $251,175 Sale
ESPOSITO PAMELA director director
Common Stock 6,350 $47.75 $303,187 Option
ESPOSITO PAMELA director director
Stock Option (Right to Buy) 5,000 $14.18 $70,900 Sale
ESPOSITO PAMELA director director
Common Stock 7,150 $48.75 $348,584 Option
ALBERS JEFFREY W. director director
Stock Option (Right to Buy) 5,000 $10.34 $51,700 Option
ALBERS JEFFREY W. director director
Common Stock 5,000 $10.34 $51,700 Sale
ALBERS JEFFREY W. director director
Common Stock 5,000 $49.1 $245,510 Purchase
BAKER BROS. ADVISORS LP director director
Prefunded Warrants 2,246,587 N/A N/A Purchase
BAKER BROS. ADVISORS LP director director
Prefunded Warrants 347,572 N/A N/A Purchase
BVF PARTNERS L P/IL director, other: See Remarks and Footn.. director, other: See Remarks an..
Pre-Funded Warrants to Purchase Common Stock 201,546 N/A N/A Purchase
BVF PARTNERS L P/IL director, other: See Remarks and Footn.. director, other: See Remarks an..
Pre-Funded Warrants to Purchase Common Stock 156,742 N/A N/A Purchase
BAKER BROS. ADVISORS LP director director
Common Stock 1 $46.41 $46 Option
GOLLOB JARED officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 23,145 $2.08 $48,142 Sale
GOLLOB JARED officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 13,281 $45.59 $605,521 Sale
GOLLOB JARED officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 9,864 $46.1 $454,701 Option
GOLLOB JARED officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 23,145 $2.08 $48,142 Option
GOLLOB JARED officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 16,455 $2.08 $34,226 Sale
GOLLOB JARED officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 16,455 $45.15 $742,927 Option
GOLLOB JARED officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 16,455 $2.08 $34,226 Sale
BOOTH BRUCE director director
Common Stock 24,449 $35.57 $869,651 Sale
BOOTH BRUCE director director
Common Stock 28,718 $36.4 $1,045,335 Sale
BOOTH BRUCE director director
Common Stock 41,763 $37.41 $1,562,354 Sale
BOOTH BRUCE director director
Common Stock 183,868 $38.48 $7,075,241 Sale
BOOTH BRUCE director director
Common Stock 96,386 $39.26 $3,784,114 Sale
BOOTH BRUCE director director
Common Stock 5,133 $35.57 $182,581 Sale
BOOTH BRUCE director director
Common Stock 6,030 $36.4 $219,492 Sale
BOOTH BRUCE director director
Common Stock 8,769 $37.41 $328,048 Sale
BOOTH BRUCE director director
Common Stock 38,606 $38.48 $1,485,559 Sale
BOOTH BRUCE director director
Common Stock 20,238 $39.26 $794,544 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 18,773 $5.33 $100,060 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 18,773 $5.33 $100,060 Option
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 25,000 $2.08 $52,000 Option
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (Right to Buy) 25,000 $2.08 $52,000 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 14,413 $2.08 $29,979 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 14,413 $2.08 $29,979 Sale
BOOTH BRUCE director director
Common Stock 8,430 $34.98 $294,881 Sale
BOOTH BRUCE director director
Common Stock 1,770 $34.98 $61,915 Sale
BOOTH BRUCE director director
Common Stock 11,838 $35.35 $418,473 Sale
BOOTH BRUCE director director
Common Stock 1,997 $36.02 $71,932 Sale
BOOTH BRUCE director director
Common Stock 2,485 $35.35 $87,845 Sale
BOOTH BRUCE director director
Common Stock 420 $36.02 $15,128 Option
HOROBIN JOANNA director director
Stock Option (Right to Buy) 8,500 $2.08 $17,680 Sale
HOROBIN JOANNA director director
Common Stock 6,313 $33.11 $209,004 Option
HOROBIN JOANNA director director
Common Stock 8,500 $2.08 $17,680 Sale
HOROBIN JOANNA director director
Common Stock 2,187 $32.65 $71,395