Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 119,293 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 79,522 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 66,334 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 66,334 $12.02 $797,003 Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 60,872 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 110,000 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 110,000 $11.45 $1,259,830 Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 148,565 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 218,811 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 77,039 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 77,039 $11.98 $922,542 Option
DEMPSEY JAMES F. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 75,243 N/A N/A Sale
DEMPSEY JAMES F. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 75,243 N/A N/A Option
DEMPSEY JAMES F. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 75,243 N/A N/A Option
GOLD MARK STEPHEN director director
Warrant to Purchase Common Stock 25,104 N/A N/A Option
GOLD MARK STEPHEN director director
Common Stock 25,104 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 106,781 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 77,634 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 23,505 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 72,972 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 28,264 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 17,517 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 89,700 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 115,860 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 97,680 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 81,814 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 178,556 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 48,950 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 3,100 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 63,630 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 132,767 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 104,006 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 113,877 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 28,661 N/A N/A Purchase
BANSAL AJAY officer: Chief Financial Officer officer: Chief Financial Officer
Warrant to Purchase Common Stock 12,519 N/A N/A Purchase
BANSAL AJAY officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 62,597 N/A N/A Purchase
BONITA DAVID P director, 10 percent owner director, 10 percent owner
Warrants to purchase common stock 66,114 N/A N/A Purchase
BONITA DAVID P director, 10 percent owner director, 10 percent owner
Common Stock, par value $0.01 per share 330,577 N/A N/A Purchase
MCKINNELL HENRY A director director
Warrant to Purchase Common Stock 62,597 N/A N/A Purchase
MCKINNELL HENRY A director director
Common Stock 312,989 N/A N/A Purchase
GOLD MARK STEPHEN director director
Warrant to Purchase Common Stock 15,648 N/A N/A Purchase
GOLD MARK STEPHEN director director
Common Stock 78,246 N/A N/A Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Warrants to purchase common stock 66,114 N/A N/A Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock, par value $0.01 per share 330,577 N/A N/A Purchase
PURI ADITYA director director
Warrant to Purchase Common Stock 441,840 N/A N/A Purchase
PURI ADITYA director director
Common Stock 1,472,803 N/A N/A Purchase
BONITA DAVID P director, 10 percent owner director, 10 percent owner
Warrants to purchase common stock 341,421 N/A N/A Purchase
BONITA DAVID P director, 10 percent owner director, 10 percent owner
Common Stock, par value $0.01 per share 1,138,074 N/A N/A Purchase
MCKINNELL HENRY A director director
Warrant to Purchase Common Stock 100,418 N/A N/A Purchase
MCKINNELL HENRY A director director
Common Stock 334,728 N/A N/A