| Utility: Polynucleotide agents targeting factor XII (hageman factor) (F12) and methods of use thereof Filling date: 9 Sep 2025 Issue date: 5 Jan 2021 | 6 Jan 2017 | 5 Jan 2021 |
| Utility: Methods and compositions for treating a proprotein convertase subtilisin kexin (PCSK9) gene-associated disorder Filling date: 9 Sep 2025 Issue date: 1 Dec 2020 | 16 Jan 2020 | 1 Dec 2020 |
| Utility: Glucokinase (GCK) iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 24 Nov 2020 | 21 Dec 2017 | 24 Nov 2020 |
| Utility: TMPRSS6 iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 10 Nov 2020 | 7 Feb 2019 | 10 Nov 2020 |
| Utility: Angiotensinogen (AGT) iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 27 Oct 2020 | 13 Feb 2019 | 27 Oct 2020 |
| Utility: Carbohydrate conjugates as delivery agents for oligonucleotides Filling date: 9 Sep 2025 Issue date: 20 Oct 2020 | 20 Nov 2018 | 20 Oct 2020 |
| Utility: Oligonucleotide-ligand conjugates and process for their preparation Filling date: 9 Sep 2025 Issue date: 20 Oct 2020 | 11 Jul 2014 | 20 Oct 2020 |
| Utility: Sterol regulatory element binding protein (SREBP) chaperone (SCAP) iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 8 Sep 2020 | 7 Jun 2018 | 8 Sep 2020 |
| Utility: Compositions and methods for inhibiting expression of CD274/PD-L1 gene Filling date: 9 Sep 2025 Issue date: 18 Aug 2020 | 27 Feb 2018 | 18 Aug 2020 |
| Utility: Compositions and methods for inhibiting expression of the LECT2 gene Filling date: 9 Sep 2025 Issue date: 18 Aug 2020 | 8 Apr 2016 | 18 Aug 2020 |
| Utility: Polynucleotide agents targeting angiotensinogen (AGT) and methods of use thereof Filling date: 9 Sep 2025 Issue date: 14 Jul 2020 | 25 May 2016 | 14 Jul 2020 |
| Utility: Serpina1 iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 16 Jun 2020 | 11 Nov 2019 | 16 Jun 2020 |
| Utility: Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated diseases Filling date: 9 Sep 2025 Issue date: 16 Jun 2020 | 18 Dec 2018 | 16 Jun 2020 |
| Utility: Modified iRNA agents Filling date: 9 Sep 2025 Issue date: 9 Jun 2020 | 27 Feb 2018 | 9 Jun 2020 |
| Utility: Therapeutic compositions Filling date: 9 Sep 2025 Issue date: 2 Jun 2020 | 14 Mar 2019 | 2 Jun 2020 |
| Utility: Modified RNAi agents Filling date: 9 Sep 2025 Issue date: 2 Jun 2020 | 19 Oct 2018 | 2 Jun 2020 |
| Utility: Compositions and methods directed to treating liver fibrosis Filling date: 9 Sep 2025 Issue date: 2 Jun 2020 | 26 Feb 2018 | 2 Jun 2020 |
| Utility: Hepatitis D virus (HDV) iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 5 May 2020 | 10 May 2017 | 5 May 2020 |
| Utility: Modified double-stranded RNA agents Filling date: 9 Sep 2025 Issue date: 7 Apr 2020 | 15 Apr 2019 | 7 Apr 2020 |
| Utility: Modified double-stranded RNA agents Filling date: 9 Sep 2025 Issue date: 7 Apr 2020 | 11 Feb 2019 | 7 Apr 2020 |
| Utility: Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (PNPLA3) and methods of use thereof Filling date: 9 Sep 2025 Issue date: 24 Mar 2020 | 12 Mar 2018 | 24 Mar 2020 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 25 Feb 2020 | 12 Oct 2017 | 25 Feb 2020 |
| Utility: RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases Filling date: 9 Sep 2025 Issue date: 25 Feb 2020 | 21 Jun 2016 | 25 Feb 2020 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 11 Feb 2020 | 18 Jun 2019 | 11 Feb 2020 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 4 Feb 2020 | 18 Jun 2019 | 4 Feb 2020 |
| Utility: Monomers and oligonucleotides comprising cycloaddition adduct(s) Filling date: 9 Sep 2025 Issue date: 4 Feb 2020 | 30 Dec 2016 | 4 Feb 2020 |
| Utility: Hepatitis B virus (HBV) iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 24 Dec 2019 | 10 May 2017 | 24 Dec 2019 |
| Utility: Compositions and methods for inhibiting expression of the PCSK9 gene Filling date: 9 Sep 2025 Issue date: 10 Dec 2019 | 8 Nov 2017 | 10 Dec 2019 |
| Utility: Compositions and methods for inhibiting expression of factor V Filling date: 9 Sep 2025 Issue date: 10 Dec 2019 | 14 Aug 2017 | 10 Dec 2019 |
| Utility: Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 3 Dec 2019 | 8 Jul 2016 | 3 Dec 2019 |
| Utility: Compositions and methods for inhibition of HAO1 (Hydroxyacid Oxidase 1 (Glycolate Oxidase)) gene expression Filling date: 9 Sep 2025 Issue date: 19 Nov 2019 | 9 Oct 2015 | 19 Nov 2019 |
| Utility: Lipid formulated compositions and methods for inhibiting expression of Serum Amyloid A gene Filling date: 9 Sep 2025 Issue date: 12 Nov 2019 | 19 Dec 2017 | 12 Nov 2019 |
| Utility: Complement component iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 5 Nov 2019 | 8 Jun 2016 | 5 Nov 2019 |
| Utility: Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 10 Sep 2019 | 17 May 2017 | 10 Sep 2019 |
| Utility: Compositions and methods for inhibiting expression of the ALAS1 gene Filling date: 9 Sep 2025 Issue date: 3 Sep 2019 | 13 Mar 2017 | 3 Sep 2019 |
| Utility: Polynucleotide agents targeting complement component C5 and methods of use thereof Filling date: 9 Sep 2025 Issue date: 3 Sep 2019 | 6 Mar 2017 | 3 Sep 2019 |
| Utility: Oligonucleotide end caps Filling date: 9 Sep 2025 Issue date: 20 Aug 2019 | 25 Oct 2016 | 20 Aug 2019 |
| Utility: Ketohexokinase (KHK) iRNA compositions and methods of use thereof Filling date: 9 Sep 2025 Issue date: 6 Aug 2019 | 1 Aug 2016 | 6 Aug 2019 |
| Utility: Biodegradable lipids for the delivery of active agents Filling date: 9 Sep 2025 Issue date: 6 Aug 2019 | 2 Apr 2015 | 6 Aug 2019 |
