| Utility: DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF ATYPICAL HEMOLYTIC UREMIC SYNDROME (AHUS) Filling date: 8 Sep 2025 Issue date: 28 Jul 2022 | 24 Jan 2020 | 28 Jul 2022 |
| Utility: METHODS OF TREATING VITILIGO USING AN ANTI-C5 ANTIBODY Filling date: 8 Sep 2025 Issue date: 21 Jul 2022 | 20 May 2020 | 21 Jul 2022 |
| Utility: MONOVALENT ANTI-PROPERDIN ANTIBODIES AND ANTIBODY FRAGMENTS Filling date: 8 Sep 2025 Issue date: 26 May 2022 | 9 Nov 2021 | 26 May 2022 |
| Utility: MANUFACTURING OF GLYCOPROTEINS Filling date: 8 Sep 2025 Issue date: 19 May 2022 | 24 Jan 2022 | 19 May 2022 |
| Utility: METHODS FOR TREATING INTRACRANIAL HEMORRHAGE AND ASSESSING EFFICACY Filling date: 8 Sep 2025 Issue date: 28 Apr 2022 | 7 Feb 2020 | 28 Apr 2022 |
| Utility: ANTI-ALK2 ANTIBODIES AND USES THEREOF Filling date: 8 Sep 2025 Issue date: 31 Mar 2022 | 5 Dec 2019 | 31 Mar 2022 |
| Utility: SUBCUTANEOUS DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) Filling date: 8 Sep 2025 Issue date: 23 Dec 2021 | 30 Oct 2019 | 23 Dec 2021 |
| Utility: INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR XA DERIVATIVES Filling date: 8 Sep 2025 Issue date: 9 Dec 2021 | 16 Feb 2021 | 9 Dec 2021 |
| Utility: ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME Filling date: 8 Sep 2025 Issue date: 4 Nov 2021 | 9 Mar 2021 | 4 Nov 2021 |
| Utility: DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF ATYPICAL HEMOLYTIC UREMIC SYNDROME (aHUS) IN PEDIATRIC PATIENTS Filling date: 8 Sep 2025 Issue date: 28 Oct 2021 | 29 May 2019 | 28 Oct 2021 |
| Utility: MANUFACTURING OF GLYCOPROTEINS Filling date: 8 Sep 2025 Issue date: 14 Oct 2021 | 13 Mar 2019 | 14 Oct 2021 |
| Utility: LYOPHILIZED FORMULATIONS FOR FACTOR XA ANTIDOTE Filling date: 8 Sep 2025 Issue date: 16 Sep 2021 | 28 May 2021 | 16 Sep 2021 |
| Utility: ATYPICAL HEMOLYTIC UREMIC SYNDROME (AHUS) BIOMARKER PROTEINS Filling date: 8 Sep 2025 Issue date: 16 Sep 2021 | 29 Jan 2021 | 16 Sep 2021 |
| Utility: ANTIBODY IMMUNE CELL INHIBITOR FUSION PROTEINS Filling date: 8 Sep 2025 Issue date: 26 Aug 2021 | 23 Apr 2018 | 26 Aug 2021 |
| Utility: COMPOSITIONS COMPRISING AN ANTI-C5 ANTIBODY Filling date: 8 Sep 2025 Issue date: 15 Jul 2021 | 19 Jan 2021 | 15 Jul 2021 |
| Utility: DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) IN PEDIATRIC PATIENTS Filling date: 8 Sep 2025 Issue date: 15 Jul 2021 | 29 May 2019 | 15 Jul 2021 |
| Utility: EFFICACY OF AN ANTI-C5 ANTIBODY IN THE PREVENTION OF ANTIBODY MEDIATED REJECTION IN SENSITIZED RECIPIENTS OF KIDNEY TRANSPLANT Filling date: 8 Sep 2025 Issue date: 24 Jun 2021 | 27 Oct 2020 | 24 Jun 2021 |
| Utility: METHODS FOR TREATING DISEASES ASSOCIATED WITH CILIOPATHIES Filling date: 8 Sep 2025 Issue date: 24 Jun 2021 | 12 Oct 2018 | 24 Jun 2021 |
| Utility: BIODEGRADABLE ACTIVATED POLYMERS FOR THERAPEUTIC DELIVERY Filling date: 8 Sep 2025 Issue date: 24 Jun 2021 | 28 Feb 2017 | 24 Jun 2021 |
| Utility: ALKALINE PHOSPHATASE POLYPEPTIDES AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 10 Jun 2021 | 9 Dec 2020 | 10 Jun 2021 |
| Utility: LYSOSOMAL STORAGE DISEASE ENZYMES Filling date: 8 Sep 2025 Issue date: 10 Jun 2021 | 9 Nov 2020 | 10 Jun 2021 |
| Utility: METHODS OF TREATING NEUROFIBROMATOSIS TYPE 1 AND RELATED CONDITIONS WITH ALKALINE PHOSPHATASE Filling date: 8 Sep 2025 Issue date: 3 Jun 2021 | 9 Aug 2019 | 3 Jun 2021 |
| Utility: SOLID FORMS OF CERDULATINIB Filling date: 8 Sep 2025 Issue date: 6 May 2021 | 16 Nov 2020 | 6 May 2021 |
| Utility: METHODS OF PRODUCING ANTI-C5 ANTIBODIES Filling date: 8 Sep 2025 Issue date: 29 Apr 2021 | 27 Jun 2019 | 29 Apr 2021 |
| Utility: LIQUID FORMULATIONS OF ANTI-CD200 ANTIBODIES Filling date: 8 Sep 2025 Issue date: 25 Mar 2021 | 18 Dec 2018 | 25 Mar 2021 |
| Utility: METHODS OF SHIFTING AN ISOELECTRIC PROFILE OF A PROTEIN PRODUCT AND USES THEREOF Filling date: 8 Sep 2025 Issue date: 4 Mar 2021 | 11 Jun 2020 | 4 Mar 2021 |
| Utility: HIGH THROUGHPUT METHOD FOR MEASURING THE PROTEASE ACTIVITY OF COMPLEMENT C3 CONVERTASE Filling date: 8 Sep 2025 Issue date: 28 Jan 2021 | 21 Mar 2019 | 28 Jan 2021 |
| Utility: POLYPEPTIDES THAT BIND COMPLEMENT COMPONENT C5 OR SERUM ALBUMIN AND FUSION PROTEINS THEREOF Filling date: 8 Sep 2025 Issue date: 24 Dec 2020 | 11 Jul 2018 | 24 Dec 2020 |
| Utility: TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA PATIENTS BY AN INHIBITOR OF COMPLEMENT Filling date: 8 Sep 2025 Issue date: 17 Dec 2020 | 23 Jan 2020 | 17 Dec 2020 |
| Utility: HIGH CONCENTRATION ANTI-C5 ANTIBODY FORMULATIONS Filling date: 8 Sep 2025 Issue date: 26 Nov 2020 | 27 Jul 2018 | 26 Nov 2020 |
| Utility: DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF GENERALIZED MYASTHENIA GRAVIS Filling date: 8 Sep 2025 Issue date: 22 Oct 2020 | 14 Feb 2020 | 22 Oct 2020 |
| Utility: METHODS OF TREATING MYOINTIMAL PROLIFERATION Filling date: 8 Sep 2025 Issue date: 1 Oct 2020 | 15 Jun 2017 | 1 Oct 2020 |
| Utility: METHODS FOR TREATING HYPOPHOSPHATASIA IN CHILDREN AND ADOLESCENTS Filling date: 8 Sep 2025 Issue date: 1 Oct 2020 | 27 Jun 2016 | 1 Oct 2020 |
| Utility: DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF PATIENTS WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS Filling date: 8 Sep 2025 Issue date: 20 Aug 2020 | 2 Oct 2018 | 20 Aug 2020 |
| Utility: METHODS OF IMPROVING CARDIOVASCULAR FUNCTION AND TREATING CARDIOVASCULAR DISEASE USING A RECOMBINANT ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE (NPP1) Filling date: 8 Sep 2025 Issue date: 20 Aug 2020 | 26 Sep 2018 | 20 Aug 2020 |
| Utility: DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) AND ATYPICAL HEMOLYTIC UREMIC SYNDROME (AHUS) Filling date: 8 Sep 2025 Issue date: 13 Aug 2020 | 26 Oct 2018 | 13 Aug 2020 |
| Utility: BIOMARKER SIGNATURE FOR PREDICTING TUMOR RESPONSE TO ANTI-CD200 THERAPY Filling date: 8 Sep 2025 Issue date: 23 Jul 2020 | 26 Sep 2018 | 23 Jul 2020 |
| Utility: METAL IMPACT ON MANUFACTURING OF ALKALINE PHOSPHATASES Filling date: 8 Sep 2025 Issue date: 16 Jul 2020 | 6 Jun 2017 | 16 Jul 2020 |
| Utility: ANTI-C5A ANTIBODIES Filling date: 8 Sep 2025 Issue date: 2 Jul 2020 | 12 Sep 2019 | 2 Jul 2020 |
| Utility: TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA PATIENTS BY AN INHIBITOR OF COMPLEMENT Filling date: 8 Sep 2025 Issue date: 25 Jun 2020 | 28 Feb 2020 | 25 Jun 2020 |
| Utility: METHODS OF TREATING A SUBJECT WITH AN ALKALINE PHOSPHATASE DEFICIENCY Filling date: 8 Sep 2025 Issue date: 11 Jun 2020 | 19 Feb 2020 | 11 Jun 2020 |
| Utility: METHODS OF REPLICATING A LARGE SCALE ECULIZUMAB PRODUCTION CELL CULTURE Filling date: 8 Sep 2025 Issue date: 4 Jun 2020 | 10 Dec 2019 | 4 Jun 2020 |
| Utility: DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF PROTEIN-LOSING ENTEROPATHY IN PATIENTS Filling date: 8 Sep 2025 Issue date: 4 Jun 2020 | 21 May 2018 | 4 Jun 2020 |
| Utility: ANTI-C5 ANTIBODIES HAVING IMPROVED PHARMACOKINETICS Filling date: 8 Sep 2025 Issue date: 21 May 2020 | 23 Jan 2020 | 21 May 2020 |
| Utility: METHODS FOR TREATING COMPLEMENT-ASSOCIATED DISORDERS Filling date: 8 Sep 2025 Issue date: 7 May 2020 | 11 Oct 2019 | 7 May 2020 |
| Utility: EFFICACY OF AN ANTI-C5 ANTIBODY IN THE PREVENTION OF ANTIBODY MEDIATED REJECTION IN SENSITIZED RECIPIENTS OF A KIDNEY TRANSPLANT Filling date: 8 Sep 2025 Issue date: 23 Apr 2020 | 17 Apr 2018 | 23 Apr 2020 |
| Utility: METHODS FOR IDENTIFYING THE HEALTH STATE OF HYPOPHOSPHATASIA (HPP) PATIENTS Filling date: 8 Sep 2025 Issue date: 23 Apr 2020 | 10 Apr 2018 | 23 Apr 2020 |
| Utility: COMPOSITIONS COMPRISING AN ANTI-C5 ANTIBODY Filling date: 8 Sep 2025 Issue date: 2 Apr 2020 | 9 Oct 2019 | 2 Apr 2020 |
| Utility: METHODS FOR TREATING HYPOPHOSPHATASIA (HPP) IN ADULTS AND ADOLESCENTS Filling date: 8 Sep 2025 Issue date: 2 Apr 2020 | 29 Mar 2018 | 2 Apr 2020 |
| Utility: TREATING SEIZURE WITH RECOMBINANT ALKALINE PHOSPHATASE Filling date: 8 Sep 2025 Issue date: 26 Mar 2020 | 18 Oct 2019 | 26 Mar 2020 |
