| Utility: Method of treating conditions related to the PGI2 receptor Filling date: 8 Sep 2025 Issue date: 30 Aug 2022 | 12 Apr 2021 | 30 Aug 2022 |
| Utility: 5-HT.sub.2C receptor agonists and compositions and methods of use Filling date: 8 Sep 2025 Issue date: 26 Jul 2022 | 14 Apr 2020 | 26 Jul 2022 |
| Utility: Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto Filling date: 8 Sep 2025 Issue date: 24 May 2022 | 6 Dec 2018 | 24 May 2022 |
| Utility: Cannabinoid receptor modulators Filling date: 8 Sep 2025 Issue date: 4 Jan 2022 | 24 Sep 2019 | 4 Jan 2022 |
| Utility: Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclopenta[B]indol-3-yl)acetic acid and salts thereof Filling date: 8 Sep 2025 Issue date: 19 Oct 2021 | 16 Aug 2016 | 19 Oct 2021 |
| Utility: Compositions comprising PGI2-receptor agonists and processes for the preparation thereof Filling date: 8 Sep 2025 Issue date: 21 Sep 2021 | 16 Apr 2019 | 21 Sep 2021 |
| Utility: Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto Filling date: 8 Sep 2025 Issue date: 24 Aug 2021 | 30 Apr 2020 | 24 Aug 2021 |
| Utility: Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3, 4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(compound1) for use in S1P.sub.1 receptor-associated disorders Filling date: 8 Sep 2025 Issue date: 17 Aug 2021 | 30 Apr 2020 | 17 Aug 2021 |
| Utility: Methods of treating conditions related to the S1P.sub.1 receptor Filling date: 8 Sep 2025 Issue date: 18 May 2021 | 6 Jan 2016 | 18 May 2021 |
| Utility: Method of treating conditions related to the PGI2 receptor Filling date: 8 Sep 2025 Issue date: 11 May 2021 | 8 May 2020 | 11 May 2021 |
| Utility: Crystalline forms and processes for the preparation of cannabinoid receptor modulators Filling date: 8 Sep 2025 Issue date: 20 Apr 2021 | 10 Dec 2018 | 20 Apr 2021 |
| Utility: Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto Filling date: 8 Sep 2025 Issue date: 23 Feb 2021 | 12 May 2020 | 23 Feb 2021 |
| Utility: 5-HT2C receptor agonists and compositions and methods of use Filling date: 8 Sep 2025 Issue date: 17 Nov 2020 | 18 Aug 2017 | 17 Nov 2020 |
| Utility: Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators Filling date: 8 Sep 2025 Issue date: 6 Oct 2020 | 15 Oct 2018 | 6 Oct 2020 |
| Utility: Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor Filling date: 8 Sep 2025 Issue date: 29 Sep 2020 | 25 Jul 2018 | 29 Sep 2020 |
| Utility: 3-phenyl-pyrazole derivatives as modulators of the 5-HT.sub.2A serotonin receptor useful for the treatment of disorders related thereto Filling date: 8 Sep 2025 Issue date: 22 Sep 2020 | 1 Nov 2018 | 22 Sep 2020 |
| Utility: Method of treating conditions related to the PGI2 receptor Filling date: 8 Sep 2025 Issue date: 23 Jun 2020 | 6 Dec 2019 | 23 Jun 2020 |
| Utility: Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto Filling date: 8 Sep 2025 Issue date: 23 Jun 2020 | 6 Nov 2018 | 23 Jun 2020 |
| Utility: Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclo-penta [b]indol-3-yl)acetic acid(Compound 1) for use in SIPI receptor-associated disorders Filling date: 8 Sep 2025 Issue date: 9 Jun 2020 | 9 Apr 2019 | 9 Jun 2020 |
| Utility: Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto Filling date: 8 Sep 2025 Issue date: 2 Jun 2020 | 2 Mar 2017 | 2 Jun 2020 |
| Utility: Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto Filling date: 8 Sep 2025 Issue date: 26 May 2020 | 6 Sep 2019 | 26 May 2020 |
| Utility: Cannabinoid receptor modulators Filling date: 8 Sep 2025 Issue date: 28 Apr 2020 | 8 Feb 2017 | 28 Apr 2020 |
| Utility: 5-HT.sub.2C receptor agonists and compositions and methods of use Filling date: 8 Sep 2025 Issue date: 21 Apr 2020 | 12 Mar 2019 | 21 Apr 2020 |
| Utility: Composition of a 5-HT2A serotonin receptor modulator useful for the treatment of disorders related thereto Filling date: 8 Sep 2025 Issue date: 10 Mar 2020 | 27 Sep 2018 | 10 Mar 2020 |
| Utility: Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro- -phenyl)-urea and crystalline forms related thereto Filling date: 8 Sep 2025 Issue date: 28 Jan 2020 | 7 Aug 2018 | 28 Jan 2020 |
| Utility: Method of treating conditions related to the PGI2 receptor Filling date: 8 Sep 2025 Issue date: 21 Jan 2020 | 22 Oct 2015 | 21 Jan 2020 |
| Utility: Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto Filling date: 8 Sep 2025 Issue date: 19 Nov 2019 | 4 Jun 2019 | 19 Nov 2019 |
| Utility: Modified-release dosage forms of 5-HT.sub.2C agonists useful for weight management Filling date: 8 Sep 2025 Issue date: 5 Nov 2019 | 7 Jan 2019 | 5 Nov 2019 |
| Utility: Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto Filling date: 8 Sep 2025 Issue date: 22 Oct 2019 | 22 Aug 2016 | 22 Oct 2019 |
| Utility: 5-HT.sub.2C receptor agonists and compositions and methods of use Filling date: 8 Sep 2025 Issue date: 27 Aug 2019 | 26 Apr 2016 | 27 Aug 2019 |
