| Utility: Method of treating conditions related to the PGI2 receptor Filling date: 8 Sep 2025 Issue date: 30 Aug 2022 | 12 Apr 2021 | 30 Aug 2022 |
| Utility: PROCESSES FOR THE PREPARATION OF (R)-2-(7-(4-CYCLOPENTYL-3-(TRIFLUOROMETHYL)BENZYLOXY)-1,2,3,4-TETRAHYDROC- YCLOPENTA[B]INDOL-3-YL)ACETIC ACID AND SALTS THEREOF Filling date: 8 Sep 2025 Issue date: 18 Aug 2022 | 14 Sep 2021 | 18 Aug 2022 |
| Utility: CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 4 Aug 2022 | 17 Sep 2021 | 4 Aug 2022 |
| Utility: 5-HT.sub.2C receptor agonists and compositions and methods of use Filling date: 8 Sep 2025 Issue date: 26 Jul 2022 | 14 Apr 2020 | 26 Jul 2022 |
| Utility: COMPOSITION OF A 5-HT2A SEROTONIN RECEPTOR MODULATOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 26 May 2022 | 1 Jul 2021 | 26 May 2022 |
| Utility: Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto Filling date: 8 Sep 2025 Issue date: 24 May 2022 | 6 Dec 2018 | 24 May 2022 |
| Utility: METHODS OF TREATING CONDITIONS RELATED TO THE S1P1 RECEPTOR Filling date: 8 Sep 2025 Issue date: 12 May 2022 | 8 Jan 2020 | 12 May 2022 |
| Utility: METHODS OF TREATING CONDITIONS RELATED TO THE S1P1 RECEPTOR Filling date: 8 Sep 2025 Issue date: 27 Jan 2022 | 26 Nov 2019 | 27 Jan 2022 |
| Utility: CRYSTALLINE L-ARGININE SALT OF (R)-2-(7-(4-CYCLOPENTYL-3- (TRIFLUOROMETHYL)BENZYLOXY)-1,2,3, 4-TETRAHYDROCYCLO-PENTA [B]INDOL-3-YL)ACETIC ACID(COMPOUND1) FOR USE IN SIPI RECEPTOR-ASSOCIATED DISORDERS Filling date: 8 Sep 2025 Issue date: 6 Jan 2022 | 14 Jul 2021 | 6 Jan 2022 |
| Utility: Cannabinoid receptor modulators Filling date: 8 Sep 2025 Issue date: 4 Jan 2022 | 24 Sep 2019 | 4 Jan 2022 |
| Utility: METHODS FOR THE TREATMENT OF SCLERODERMA Filling date: 8 Sep 2025 Issue date: 16 Dec 2021 | 3 Oct 2019 | 16 Dec 2021 |
| Utility: COMPOSITIONS COMPRISING PGI2-RECEPTOR AGONISTS AND PROCESSES FOR THE PREPARATION THEREOF Filling date: 8 Sep 2025 Issue date: 9 Dec 2021 | 12 Aug 2021 | 9 Dec 2021 |
| Utility: CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 9 Dec 2021 | 16 Mar 2021 | 9 Dec 2021 |
| Utility: PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 9 Dec 2021 | 18 Feb 2021 | 9 Dec 2021 |
| Utility: METHODS OF TREATING CONDITIONS RELATED TO THE S1P1 RECEPTOR Filling date: 8 Sep 2025 Issue date: 4 Nov 2021 | 20 Apr 2021 | 4 Nov 2021 |
| Utility: MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 4 Nov 2021 | 15 Dec 2020 | 4 Nov 2021 |
| Utility: MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 4 Nov 2021 | 14 Dec 2020 | 4 Nov 2021 |
| Utility: COMPOUNDS USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS Filling date: 8 Sep 2025 Issue date: 4 Nov 2021 | 5 Sep 2019 | 4 Nov 2021 |
| Utility: Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclopenta[B]indol-3-yl)acetic acid and salts thereof Filling date: 8 Sep 2025 Issue date: 19 Oct 2021 | 16 Aug 2016 | 19 Oct 2021 |
| Utility: METHOD OF TREATING CONDITIONS RELATED TO THE PGI2 RECEPTOR Filling date: 8 Sep 2025 Issue date: 23 Sep 2021 | 12 Apr 2021 | 23 Sep 2021 |
| Utility: Compositions comprising PGI2-receptor agonists and processes for the preparation thereof Filling date: 8 Sep 2025 Issue date: 21 Sep 2021 | 16 Apr 2019 | 21 Sep 2021 |
| Utility: Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto Filling date: 8 Sep 2025 Issue date: 24 Aug 2021 | 30 Apr 2020 | 24 Aug 2021 |
| Utility: Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3, 4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(compound1) for use in S1P.sub.1 receptor-associated disorders Filling date: 8 Sep 2025 Issue date: 17 Aug 2021 | 30 Apr 2020 | 17 Aug 2021 |
| Utility: METHODS OF TREATING CONDITIONS RELATED TO THE S1P1 RECEPTOR Filling date: 8 Sep 2025 Issue date: 29 Jul 2021 | 5 Jun 2019 | 29 Jul 2021 |
| Utility: 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE Filling date: 8 Sep 2025 Issue date: 15 Jul 2021 | 19 Oct 2020 | 15 Jul 2021 |
| Utility: COMPOSITIONS COMPRISING PGI2-RECEPTOR AGONISTS AND PROCESSES FOR THE PREPARATION THEREOF Filling date: 8 Sep 2025 Issue date: 15 Jul 2021 | 23 May 2019 | 15 Jul 2021 |
| Utility: CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 24 Jun 2021 | 18 Sep 2020 | 24 Jun 2021 |
| Utility: Methods of treating conditions related to the S1P.sub.1 receptor Filling date: 8 Sep 2025 Issue date: 18 May 2021 | 6 Jan 2016 | 18 May 2021 |
| Utility: Method of treating conditions related to the PGI2 receptor Filling date: 8 Sep 2025 Issue date: 11 May 2021 | 8 May 2020 | 11 May 2021 |
| Utility: IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 6 May 2021 | 9 Sep 2020 | 6 May 2021 |
| Utility: Crystalline forms and processes for the preparation of cannabinoid receptor modulators Filling date: 8 Sep 2025 Issue date: 20 Apr 2021 | 10 Dec 2018 | 20 Apr 2021 |
| Utility: PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR Filling date: 8 Sep 2025 Issue date: 8 Apr 2021 | 19 Aug 2020 | 8 Apr 2021 |
| Utility: CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 4 Mar 2021 | 15 Apr 2020 | 4 Mar 2021 |
| Utility: Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto Filling date: 8 Sep 2025 Issue date: 23 Feb 2021 | 12 May 2020 | 23 Feb 2021 |
| Utility: SUBSTITUTED (1,2,3,4-TETRAHYDROCYCLOPENTA[b]INDOL-3-YL)ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS Filling date: 8 Sep 2025 Issue date: 31 Dec 2020 | 8 Jun 2020 | 31 Dec 2020 |
| Utility: DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 24 Dec 2020 | 24 Feb 2020 | 24 Dec 2020 |
| Utility: COMPOSITION OF A 5-HT2A SEROTONIN RECEPTOR MODULATOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 24 Dec 2020 | 23 Jan 2020 | 24 Dec 2020 |
| Utility: PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 17 Dec 2020 | 30 Apr 2020 | 17 Dec 2020 |
| Utility: SUBSTITUTED PYRIDAZINES AND 1,2,4-TRIAZINES AS PROSTACYCLIN RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 10 Dec 2020 | 25 Aug 2020 | 10 Dec 2020 |
| Utility: 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE Filling date: 8 Sep 2025 Issue date: 10 Dec 2020 | 14 Apr 2020 | 10 Dec 2020 |
| Utility: MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 10 Dec 2020 | 6 Dec 2018 | 10 Dec 2020 |
| Utility: MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 3 Dec 2020 | 14 Apr 2020 | 3 Dec 2020 |
| Utility: METHODS OF TREATMENT Filling date: 8 Sep 2025 Issue date: 26 Nov 2020 | 7 Aug 2018 | 26 Nov 2020 |
| Utility: CRYSTALLINE L-ARGININE SALT OF (R)-2-(7-(4-CYCLOPENTYL-3- (TRIFLUOROMETHYL)BENZYLOXY)-1,2,3, 4-TETRAHYDROCYCLO-PENTA [B]INDOL-3-YL)ACETIC ACID(COMPOUND1) FOR USE IN SIPI RECEPTOR-ASSOCIATED DISORDERS Filling date: 8 Sep 2025 Issue date: 19 Nov 2020 | 30 Apr 2020 | 19 Nov 2020 |
| Utility: 5-HT2C receptor agonists and compositions and methods of use Filling date: 8 Sep 2025 Issue date: 17 Nov 2020 | 18 Aug 2017 | 17 Nov 2020 |
| Utility: Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators Filling date: 8 Sep 2025 Issue date: 6 Oct 2020 | 15 Oct 2018 | 6 Oct 2020 |
| Utility: Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor Filling date: 8 Sep 2025 Issue date: 29 Sep 2020 | 25 Jul 2018 | 29 Sep 2020 |
| Utility: 3-phenyl-pyrazole derivatives as modulators of the 5-HT.sub.2A serotonin receptor useful for the treatment of disorders related thereto Filling date: 8 Sep 2025 Issue date: 22 Sep 2020 | 1 Nov 2018 | 22 Sep 2020 |
| Utility: MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 27 Aug 2020 | 12 May 2020 | 27 Aug 2020 |
| Utility: METHOD OF TREATING CONDITIONS RELATED TO THE PGI2 RECEPTOR Filling date: 8 Sep 2025 Issue date: 27 Aug 2020 | 8 May 2020 | 27 Aug 2020 |
