| Utility: PROCESSES FOR THE PREPARATION OF (R)-2-(7-(4-CYCLOPENTYL-3-(TRIFLUOROMETHYL)BENZYLOXY)-1,2,3,4-TETRAHYDROC- YCLOPENTA[B]INDOL-3-YL)ACETIC ACID AND SALTS THEREOF Filling date: 8 Sep 2025 Issue date: 18 Aug 2022 | 14 Sep 2021 | 18 Aug 2022 |
| Utility: CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 4 Aug 2022 | 17 Sep 2021 | 4 Aug 2022 |
| Utility: COMPOSITION OF A 5-HT2A SEROTONIN RECEPTOR MODULATOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 26 May 2022 | 1 Jul 2021 | 26 May 2022 |
| Utility: METHODS OF TREATING CONDITIONS RELATED TO THE S1P1 RECEPTOR Filling date: 8 Sep 2025 Issue date: 12 May 2022 | 8 Jan 2020 | 12 May 2022 |
| Utility: METHODS OF TREATING CONDITIONS RELATED TO THE S1P1 RECEPTOR Filling date: 8 Sep 2025 Issue date: 27 Jan 2022 | 26 Nov 2019 | 27 Jan 2022 |
| Utility: CRYSTALLINE L-ARGININE SALT OF (R)-2-(7-(4-CYCLOPENTYL-3- (TRIFLUOROMETHYL)BENZYLOXY)-1,2,3, 4-TETRAHYDROCYCLO-PENTA [B]INDOL-3-YL)ACETIC ACID(COMPOUND1) FOR USE IN SIPI RECEPTOR-ASSOCIATED DISORDERS Filling date: 8 Sep 2025 Issue date: 6 Jan 2022 | 14 Jul 2021 | 6 Jan 2022 |
| Utility: METHODS FOR THE TREATMENT OF SCLERODERMA Filling date: 8 Sep 2025 Issue date: 16 Dec 2021 | 3 Oct 2019 | 16 Dec 2021 |
| Utility: COMPOSITIONS COMPRISING PGI2-RECEPTOR AGONISTS AND PROCESSES FOR THE PREPARATION THEREOF Filling date: 8 Sep 2025 Issue date: 9 Dec 2021 | 12 Aug 2021 | 9 Dec 2021 |
| Utility: CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 9 Dec 2021 | 16 Mar 2021 | 9 Dec 2021 |
| Utility: PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 9 Dec 2021 | 18 Feb 2021 | 9 Dec 2021 |
| Utility: METHODS OF TREATING CONDITIONS RELATED TO THE S1P1 RECEPTOR Filling date: 8 Sep 2025 Issue date: 4 Nov 2021 | 20 Apr 2021 | 4 Nov 2021 |
| Utility: MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 4 Nov 2021 | 15 Dec 2020 | 4 Nov 2021 |
| Utility: MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 4 Nov 2021 | 14 Dec 2020 | 4 Nov 2021 |
| Utility: COMPOUNDS USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS Filling date: 8 Sep 2025 Issue date: 4 Nov 2021 | 5 Sep 2019 | 4 Nov 2021 |
| Utility: METHOD OF TREATING CONDITIONS RELATED TO THE PGI2 RECEPTOR Filling date: 8 Sep 2025 Issue date: 23 Sep 2021 | 12 Apr 2021 | 23 Sep 2021 |
| Utility: METHODS OF TREATING CONDITIONS RELATED TO THE S1P1 RECEPTOR Filling date: 8 Sep 2025 Issue date: 29 Jul 2021 | 5 Jun 2019 | 29 Jul 2021 |
| Utility: 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE Filling date: 8 Sep 2025 Issue date: 15 Jul 2021 | 19 Oct 2020 | 15 Jul 2021 |
| Utility: COMPOSITIONS COMPRISING PGI2-RECEPTOR AGONISTS AND PROCESSES FOR THE PREPARATION THEREOF Filling date: 8 Sep 2025 Issue date: 15 Jul 2021 | 23 May 2019 | 15 Jul 2021 |
| Utility: CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 24 Jun 2021 | 18 Sep 2020 | 24 Jun 2021 |
| Utility: IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 6 May 2021 | 9 Sep 2020 | 6 May 2021 |
| Utility: PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR Filling date: 8 Sep 2025 Issue date: 8 Apr 2021 | 19 Aug 2020 | 8 Apr 2021 |
| Utility: CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 4 Mar 2021 | 15 Apr 2020 | 4 Mar 2021 |
| Utility: SUBSTITUTED (1,2,3,4-TETRAHYDROCYCLOPENTA[b]INDOL-3-YL)ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS Filling date: 8 Sep 2025 Issue date: 31 Dec 2020 | 8 Jun 2020 | 31 Dec 2020 |
| Utility: DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 24 Dec 2020 | 24 Feb 2020 | 24 Dec 2020 |
| Utility: COMPOSITION OF A 5-HT2A SEROTONIN RECEPTOR MODULATOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 24 Dec 2020 | 23 Jan 2020 | 24 Dec 2020 |
| Utility: PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 17 Dec 2020 | 30 Apr 2020 | 17 Dec 2020 |
| Utility: SUBSTITUTED PYRIDAZINES AND 1,2,4-TRIAZINES AS PROSTACYCLIN RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 10 Dec 2020 | 25 Aug 2020 | 10 Dec 2020 |
| Utility: 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE Filling date: 8 Sep 2025 Issue date: 10 Dec 2020 | 14 Apr 2020 | 10 Dec 2020 |
| Utility: MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 10 Dec 2020 | 6 Dec 2018 | 10 Dec 2020 |
| Utility: MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 3 Dec 2020 | 14 Apr 2020 | 3 Dec 2020 |
| Utility: METHODS OF TREATMENT Filling date: 8 Sep 2025 Issue date: 26 Nov 2020 | 7 Aug 2018 | 26 Nov 2020 |
| Utility: CRYSTALLINE L-ARGININE SALT OF (R)-2-(7-(4-CYCLOPENTYL-3- (TRIFLUOROMETHYL)BENZYLOXY)-1,2,3, 4-TETRAHYDROCYCLO-PENTA [B]INDOL-3-YL)ACETIC ACID(COMPOUND1) FOR USE IN SIPI RECEPTOR-ASSOCIATED DISORDERS Filling date: 8 Sep 2025 Issue date: 19 Nov 2020 | 30 Apr 2020 | 19 Nov 2020 |
| Utility: MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 27 Aug 2020 | 12 May 2020 | 27 Aug 2020 |
| Utility: METHOD OF TREATING CONDITIONS RELATED TO THE PGI2 RECEPTOR Filling date: 8 Sep 2025 Issue date: 27 Aug 2020 | 8 May 2020 | 27 Aug 2020 |
| Utility: ETHERS, SECONDARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 6 Aug 2020 | 11 Sep 2019 | 6 Aug 2020 |
| Utility: PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO- -PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 7 May 2020 | 26 Dec 2019 | 7 May 2020 |
| Utility: COMPOUNDS AND METHODS FOR TREATMENT OF NAFLD AND NASH Filling date: 8 Sep 2025 Issue date: 30 Apr 2020 | 19 Jun 2018 | 30 Apr 2020 |
| Utility: METHOD OF TREATING CONDITIONS RELATED TO THE PGI2 RECEPTOR Filling date: 8 Sep 2025 Issue date: 9 Apr 2020 | 6 Dec 2019 | 9 Apr 2020 |
| Utility: 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE Filling date: 8 Sep 2025 Issue date: 12 Mar 2020 | 12 Mar 2019 | 12 Mar 2020 |
| Utility: Compounds and Methods for Treatment of Visceral Pain Filling date: 8 Sep 2025 Issue date: 12 Mar 2020 | 8 May 2018 | 12 Mar 2020 |
| Utility: CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 5 Mar 2020 | 17 Jun 2019 | 5 Mar 2020 |
| Utility: PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 13 Feb 2020 | 18 Apr 2019 | 13 Feb 2020 |
| Utility: CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 16 Jan 2020 | 24 Sep 2019 | 16 Jan 2020 |
| Utility: COMPOUNDS AND METHODS FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE WITH EXTRA-INTESTINAL MANIFESTATIONS Filling date: 8 Sep 2025 Issue date: 16 Jan 2020 | 16 Feb 2018 | 16 Jan 2020 |
| Utility: COMPOUNDS AND METHODS FOR TREATMENT OF PRIMARY BILIARY CHOLANGITIS Filling date: 8 Sep 2025 Issue date: 2 Jan 2020 | 16 Feb 2018 | 2 Jan 2020 |
| Utility: MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 26 Dec 2019 | 6 Sep 2019 | 26 Dec 2019 |
| Utility: CRYSTALLINE L-ARGININE SALT OF (R)-2-(7-(4-CYCLOPENTYL-3- (TRIFLUOROMETHYL)BENZYLOXY)-1,2,3, 4-TETRAHYDROCYCLO-PENTA [B]INDOL-3-YL)ACETIC ACID(COMPOUND1) FOR USE IN SIPI RECEPTOR-ASSOCIATED DISORDERS Filling date: 8 Sep 2025 Issue date: 31 Oct 2019 | 9 Apr 2019 | 31 Oct 2019 |
| Utility: METHODS OF TREATING PAH WITH COMBINATIONS OF RALINEPAG AND OTHER AGENTS Filling date: 8 Sep 2025 Issue date: 24 Oct 2019 | 10 Nov 2017 | 24 Oct 2019 |
| Utility: CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 10 Oct 2019 | 10 Dec 2018 | 10 Oct 2019 |
| Utility: MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 26 Sep 2019 | 4 Jun 2019 | 26 Sep 2019 |
