Option
GOLDSMITH MARK A director director
Common Stock 14,987 N/A N/A Option
GOLDSMITH MARK A director director
Stock Option (right to buy) 14,987 N/A N/A Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 6,260 $37.6 $235,376 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 6,260 $37.6 $235,376 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 6,260 $37.6 $235,376 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 4,010 $8.04 $32,240 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 4,010 $8.04 $32,240 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 4,010 $8.04 $32,240 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,100 $37.59 $41,344 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,100 $37.59 $41,344 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 1,100 $37.59 $41,344 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 410 $8.04 $3,296 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 410 $8.04 $3,296 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 410 $8.04 $3,296 Sale
COLUMN GROUP L P 10 percent owner 10 percent owner
Common Stock 10,000 $36.95 $369,500 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 17,203 $11.5 $197,835 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 17,203 $11.5 $197,835 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 17,203 $33.96 $584,248 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 17,203 $33.96 $584,248 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,720 $35.11 $200,806 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,720 $7.11 $40,641 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 5,720 $7.11 $40,641 Sale
GOLDSMITH MARK A director director
Common Stock 4,020 $35.02 $140,768 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,720 $7.11 $40,641 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 5,720 $7.11 $40,641 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 589 $7.6 $4,476 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 589 $7.6 $4,476 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 589 $37.54 $22,109 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 589 N/A N/A Option
RAYTHATHA JIGAR director, officer: See Remarks director, officer: See Remarks
Common Stock 9,209 $50.17 $461,979 Option
RAYTHATHA JIGAR director, officer: See Remarks director, officer: See Remarks
Stock Option (Right to Buy) 9,209 $50.17 $461,979 Sale
RAYTHATHA JIGAR director, officer: See Remarks director, officer: See Remarks
Common Stock 9,209 $50.17 $461,979 Sale
GOLDSMITH MARK A director director
Common Stock 4,225 $50.05 $211,474 Option
GOLDSMITH MARK A director director
Stock Option (right to buy) 4,225 $6.88 $29,081 Option
GOLDSMITH MARK A director director
Common Stock 4,225 $6.88 $29,081 Sale
SENDEROWICZ ADRIAN officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 9,357 $5.51 $51,557 Option
SENDEROWICZ ADRIAN officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 9,357 $5.51 $51,557 Option
SENDEROWICZ ADRIAN officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 9,357 $5.51 $51,557 Sale
AUDIA JAMES E director director
Common Stock 6,100 $50.1 $305,622 Option
GOLDSMITH MARK A director director
Common Stock 4,225 $6.88 $29,081 Option
GOLDSMITH MARK A director director
Stock Option (right to buy) 4,225 $6.88 $29,081 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 16,062 $49.54 $795,631 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 16,062 $8.62 $138,422 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 16,062 $8.62 $138,422 Option
RAYTHATHA JIGAR director, officer: See Remarks director, officer: See Remarks
Stock Option (Right to Buy) 26 $5.51 $143 Option
RAYTHATHA JIGAR director, officer: See Remarks director, officer: See Remarks
Common Stock 26 $5.51 $143 Sale
RAYTHATHA JIGAR director, officer: See Remarks director, officer: See Remarks
Common Stock 26 $5.51 $143 Sale
GOLDSMITH MARK A director director
Common Stock 100 $1.55 $155 Option
GOLDSMITH MARK A director director
Common Stock 100 $1.55 $155 Option
GOLDSMITH MARK A director director
Stock Option (right to buy) 100 $1.55 $155